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The Marshall Protocol Study Site > PROF. MARSHALL'S PERSPECTIVE > Prof. Marshall's Perspective > Sankyo's patent on Olmesartan Medoxomil runs until Oct 2016


Sankyo's patent on Olmesartan Medoxomil runs until Oct 2016
 Moderated by: Prof Trevor Marshall Page:  First Page Previous Page  1  2  3  Next Page Last Page  
 

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mvanwink5
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 Posted: Mon May 2nd, 2011 08:15

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Deb,
That is a good point, I have read that OM fillers can be troublesome to some folks. I would not be surprised to see this addressed in the trial PO product.

Best,
Mike



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Lyme joints, EMF sensitive, MP start 8/10; 25D <4ng/ml 6/19; vegetarian; olmesartan only-240mg/d, RF shielding required, My Progress: http://tinyurl.com/z2stwo8
y
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 Posted: Mon May 2nd, 2011 10:59

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Can someone point me to the data that is currently available for human use of PO? Is it in a paper or a video? Thanks.

Good question, Russ. From DTM's answer, I now see more advantage than I was seeing before.



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Prof Trevor Marshall
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 Posted: Mon May 2nd, 2011 14:38

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The optimum PO dosage seems to be 25mg, initial administration will be by capsule. We are trying to figure out how to bulk-manufacture the capsules without fillers, and have no solution at this point. PO works fine without fillers, however.

The only paper available was written about a study describing Intra-Venous use of PO, as it is still believed by TPTB that PO is not absorbed properly from the gut.

"Pharmacokinetics of CS-866, a new angiotensin II receptor blocker, in healthy subjects"
http://www.ncbi.nlm.nih.gov/pubmed/11361048
 

ChrisMavo
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 Posted: Mon May 2nd, 2011 14:44

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Dr Marshall, would intravenous treatment with PO be appropriate for some patients who can not swallow?  I know my swallowing is getting more compromised lately!! 



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Prof Trevor Marshall
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 Posted: Mon May 2nd, 2011 15:44

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Intra Venous delivery would work fine, but the FDA safety paperwork is pretty intense, I think. I will check up for you.
 

ChrisMavo
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 Posted: Mon May 2nd, 2011 15:49

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I did not mean to imply that I cannot swallow pills now!  I can.. just have to be extra careful when I do.  But if I progress more it may become an issue for me down the line.  And it is certainly an issue for some more advanced ALS patients.  Though they can take soft food with a pill mixed in with it. 



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Prof Trevor Marshall
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 Posted: Mon May 2nd, 2011 17:29

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Ultimately we will need  to get approval for an IV drip so that unconscious or intubated members can still be maintained on olmesartan during an emergency. I am also working on ideas for an overnight patch (when one really needs a good solid 8hr sleep)
 

Last edited on Mon May 2nd, 2011 17:30 by Prof Trevor Marshall

ChrisMavo
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 Posted: Mon May 2nd, 2011 17:38

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Wow a patch to slowly dispense the PO would be an ideal way to control the dosage for prolonged periods!!  What a great idea!!  Let's hope the FDA works speedily on this stuff.. their are a lot of sick people out there! 



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jlunn247
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 Posted: Mon May 2nd, 2011 22:57

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right on the sore spots i would need about two dozen patches.
about the size of those tiny round bandages. or an emoticon.:dude::dude::dude::dude::dude::dude::dude::dude::dude::dude::dude:



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Teresa Green
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 Posted: Tue May 3rd, 2011 18:40

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Trevor,

I seem to remember from an earlier thread that a compounding pharmacy in Australia had offered to compound Olmesartan Medoxomil as a slow release capsule that could be taken once a day.   However you had suggested that it was not reliable enough.   Was this because the Medoximil complicated the release due to its effect of slowing the body’s absorption of the Olmesartan?   If so, then given pure Olmesartan’s better pharmokinetics and lower dosage, would it be possible to have a single slow release capsule compounded that could be taken once a day?

Time release technology for pharmaceuticals has been greatly improved.   Having slow release would ensure that serum levels and cellular perfusion of pure Olmesartan would be better maintained and result in improved compliance and efficacy of the protocol.

I’d be interested in your thoughts.

Teresa

 

eClaire
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 Posted: Wed May 4th, 2011 14:34

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First, Yay! Yay! YAY!!!

Second, how nice that a drip and a patch might be coming our way.

And let's keep some pure (if time release is thought a good idea), as I've never met a time release medicine my body likes.

I'm up for the study!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!



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efrenz
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 Posted: Tue May 17th, 2011 12:27

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How does this relate to the various Olmesartan compounds that one gets online from India?

Personally, I find that the Olmecip tablets work better than the brand name Benicar, and the one time I had to buy Olmezest - they were REALLY ineffective, such that I had to take two pills at once to sense an effect.

Looking at packaging for both, they are both labelled as 'Olmesartan Medoxomil'. So I suppose there is another ingredient that makes them different.



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cbay
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 Posted: Tue May 17th, 2011 13:06

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I talked to my doctor about a PO study. He showed interest so keep me on the list. But, he was concerned about how involved he would need to be.



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Prof Trevor Marshall
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 Posted: Tue May 17th, 2011 14:39

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Efrenz, olmesartan medoxomil is a very unstable compound. Additionally, there is some dispute about how to determine the structure - several bulk manufacturing variants seem to have a butyl moeity.

I would not be surprised if there were low quality generic floating around. We all know that Sankyo has enough trouble stopping their product smelling like butter (from batch to batch). No trouble has been reported with Olmecip, however, which is sold for pennies in India.
 

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 Posted: Thu May 19th, 2011 14:43

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We all know that Sankyo has enough trouble stopping their product smelling like butter (from batch to batch).
I inquired about the butter smell and what it was  - I was told by a reputable source that it is rancid - when I offered that this seemed simplistic and that the source hadn't actually checked any data i was told again that it was rancid - period.



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pgeek
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 Posted: Fri May 20th, 2011 01:03

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Dr Trevor Marshall wrote: I would not be surprised if there were low quality generic floating around. We all know that Sankyo has enough trouble stopping their product smelling like butter (from batch to batch). No trouble has been reported with Olmecip, however, which is sold for pennies in India.A friend of mine was in India recently, and I thought he might be able to get me some. So I did check the appearance, retail price etc of the Indian generics. I think it worked out something like $30/m for 40mg q6h. Unfortunately he wasn't able to get me any. :(

The online pharmacies seem to be making markups of 2-300% over the retail price. Considerably more over the wholesale price. If anyone has any connections in retail pharmacy in India, there's an opportunity to make a lot of money - while still saving us a lot of money...

Last edited on Fri May 20th, 2011 01:49 by pgeek



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Barney
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 Posted: Sat May 21st, 2011 20:49

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Mark,
I tend to disagree with you about the butter smell indicating the Benicar is rancid. I just got my 540 pills 2 days ago and I know that the pharmacist opened all foil sealed bottles to count them into the container I get them in. I opened the bottle when I got home and they smelled like butter. They ALWAYS do.
I can't believe that all the Benicar I have received for 7 yrs now is rancid.
Don't mean to discount your theory, Mark.
HANG IN THERE, WE WILL MAKE IT!!!!BARNEY:D



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 Posted: Sat May 21st, 2011 21:46

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I think Barney's right about the butter smell; it seems to be a feature of Sankyo's manufacturing process, which leaves in some impurities.



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 Posted: Sun May 22nd, 2011 06:25

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All of my Benicar smell the same every refill. I have been told it smells like cake batter. The Olmecip pills do not smell this way, but I feel the same affect taking them.



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eClaire
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 Posted: Sun May 22nd, 2011 10:50

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Interestingly, the most recent Olmicip tabs that I opened smelled slightly buttery.  I've been taking them for 4.5 years (started with regular Benicar and could not tolerate the buttery aroma) and I've never had this happen before.



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Dec 2006, Olmesartan break Feb - April 2007, ME/Fibro/PTSD/MCS/Hypermobility (since childhood; disabled 2003); 25D summer 2012 <4 (meaning unable to detect)

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