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The Marshall Protocol Study Site > PROF. MARSHALL'S PERSPECTIVE > Prof. Marshall's Perspective > Sankyo's patent on Olmesartan Medoxomil runs until Oct 2016


Sankyo's patent on Olmesartan Medoxomil runs until Oct 2016
 Moderated by: Prof Trevor Marshall Page:  First Page Previous Page  1  2  3   
 

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Rico
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 Posted: Sun May 22nd, 2011 10:30

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Interestingly, before Olmesartan was approved for sale in Canada, we used to buy it from the U.S. and it smelled sort of buttery. The Olmetec tablets we buy now in Canada does not have this odor.



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luxman
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 Posted: Fri May 27th, 2011 06:07

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All the Olmetec (Sankyo's European olmesartan brand) I've been taking for over two years now in Luxembourg smelt like butter with no exception. Has it all been rancid?



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MP Mar'09 (break since Oct'13) | Undiagnosed | Asymptomatic, previously 24/7 dizziness, GERD, GI complaints, weakness, sciatica | Last 25D13.8 (Jan10)
leroybrown
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 Posted: Fri May 27th, 2011 06:43

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Rico - all my olmetec smells like butter.

Deb



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cbay
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 Posted: Fri May 27th, 2011 06:47

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Luxman,

I don't know about it being rancid. I have mixed Olmecip and Benicar (which all smelt buttery) and feel no difference between the two. We are talking about half a day taking Olmecip then switching. Or even taking one for a few days then the other. They both palliate and cause IP the same way for me.

Correcting my Olmesartan to say Benicar

Last edited on Fri May 27th, 2011 08:46 by cbay



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Cynthia S
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 Posted: Fri May 27th, 2011 08:14

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Are you people telling us about the olmesartan, or how good your sense of smell is?  LOL, Cynthia



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cbay
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 Posted: Fri May 27th, 2011 08:48

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That is funny to say :)

I have times where I can smell scents that others have no idea. Sometimes I wonder if I am imagining them.



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PGA Terry
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 Posted: Sun May 29th, 2011 21:31

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Funny Cynthia!..... I have about a years supply of Olmesartan (Olmecip in the blister packs) and was wondering how is the best way to store these meds so they don't go rancid. I think Dr. Marshall mentioned keeping Olmesartan in the refrigerator for long storage but I'm not sure if I am remembering that accurately. If anyone has successfully stored Olmesarten for long periods I would appreciate you sharing.

Thanks.....Terry 



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 Posted: Mon May 30th, 2011 04:16

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I have had olmesartan medoxomil tablets (Olmetec) in blister packs at -4 celsius (in our household freezer) for at least 8 months without noticing any evidence of deterioration, either in the form of an odour or of loss of effectiveness. I have also kept powdered olmesartan medoxomil in capsules in tightly sealed plastic jars at -4 celsius for about three years without evidence of deterioration.
 I have just tried one of them now, dispensed over 4 years ago by a compounding pharmacist in Melbourne. Again no smell or taste. I think the pharmacist got his supply from India and they worked well for me for the first 6 months on the MP. Then Olmetec was registered for supply on the PBS ( Pharmaceutical Benefits Scheme) and we could get it more cheaply and the tablets were easier to take. I had bought a big stock of the capsules at the end of 2006 and early in 2007. With a lot of them unused I switched back to them over the last half of 2009, early 2010 and they were fine. I have kept one jar as a souvenir or maybe for use if I need powdered olmesartan.

Last edited on Mon May 30th, 2011 04:17 by Jigsaw



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Prof Trevor Marshall
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 Posted: Mon May 30th, 2011 04:25

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Jigsaw, FYI, we just did an HPLC test run on a year-old jar of Pure Olmesartan bulk powder from our manufacturer in China, and it was still approx 99.7% pure (by HPLC)(omitting the 0.5% water). The jars have been kept at room temperature (avg 22 C)

The bulk Olmesartan Medoxomil will be less stable, the compound is far more polar, but I suspect it should be fine at lower temperatures. I don't expect capsules to interact with either the PO or OM in any way which would degrade its shelf-life. That said, most pharmaceutical grade empty-capsules are only certified for a 2-year shelf life.

It is my understanding that the Indian suppliers repackage bulk OM product from  Chinese manufacturers. China is shipping tonnes of OM, and it has to be going somewhere (probably to Sankyo in Germany, too...).
 

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 Posted: Mon May 30th, 2011 04:44

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Mark,
I tend to disagree with you about the butter smell indicating the Benicar is rancid. I just got my 540 pills 2 days ago and I know that the pharmacist opened all foil sealed bottles to count them into the container I get them in. I opened the bottle when I got home and they smelled like butter. They ALWAYS do.
I can't believe that all the Benicar I have received for 7 yrs now is rancid.
Don't mean to discount your theory, Mark.
HANG IN THERE, WE WILL MAKE IT!!!!BARNEY:D

Not my theory Barney  - I asked a PhD in Biochem. about the buttery smell.

The question I asked was

Q - "Can you identify a chemical compound by it's buttery odor?"

A  - "It's rancid".

Q - "are you sure?" 

A - "Yes - It is rancid -  period "

 My generic blister-pack Olmetec has no buttery odor.

Last edited on Mon May 30th, 2011 04:45 by Markt9452



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Joyful
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 Posted: Mon May 30th, 2011 20:20

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Mark, no disrespect to the highly educated pharm guy, but the butter odor has been documented from the beginning as some kind of undeclared impurity in the Sankyo brand Benicar tablets. They smell that way from day one.

Smells just like buttered popcorn to me. Very odd.



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 Posted: Tue May 31st, 2011 05:46

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Seems to work fine with or without the buttery goodness... :)



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 Posted: Tue May 31st, 2011 07:35

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This is indeed a great time in history, I hope we can get that PO going soon. Very, very good thing!

Best to all--Janet



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 Posted: Tue May 31st, 2011 08:00

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Another MP'er once told me that benicar's buttery smell seems to dissipate as you progress through MP. I guess the more you heal the less it smells like buttered popcorn. There may be something to it because I hardly notice the smell any more.....or maybe I have become accustomed it. :)



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 Posted: Tue Jul 5th, 2011 20:08

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May I respectfully suggest that the smell is caused by the th1 disease process itself .I used to get a sewer smell every time I ate lunch,until I realised that it was due to the combination of rice biscuit and peanut butter. I now consider myself  "cured" after 5 1/2 years and for some time now that sewer smell has gone,  so p has the buttery smell of Olmesartan.regards,



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jlunn247
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 Posted: Sun Jul 24th, 2011 11:29

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drying off after long shower i used to smell mildew on many a fresh towels  till i realised it was my own body.

the bleach in the water changed my body odor or scewed up my olfactory senses.:?
 and i cant stand fresh bread smell i got to toast it before it smells normal.

Last edited on Sun Jul 24th, 2011 11:32 by jlunn247



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 Posted: Tue Aug 2nd, 2011 20:11

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My doctor gives me Benicar samples from time to time and although I have been on the MP for 4 years now, they still always still smell buttery to me, whereas my Olmecip tablets do not have this smell to them.



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