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The Marshall Protocol Study Site > PROF. MARSHALL'S PERSPECTIVE > Prof. Marshall's Perspective > Some GWAS Researchers do draw sensible conclusions

Some GWAS Researchers do draw sensible conclusions
 Moderated by: Prof Trevor Marshall

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Prof Trevor Marshall
Foundation Staff

Joined: Fri Jul 9th, 2004
Location: Thousand Oaks, California USA
Posts: 16189
Status:  Offline
 Posted: Mon Jun 13th, 2011 03:49


Although the news from the Welcome Trust did not specifically warn about the diagnostic usefulness of a new Genome Wide Association Study (GWAS), the AFP report did. So, important things first:

"The influence of these genes is probably not large enough to be immediately used as a diagnostic tool. But the result "is an advancement of the understanding of migraine biology," he said."

And indeed that is what interests me. I haven't had a chance to really study these genes in detail, but if you read both the reports above, it appears some clarification may have emerged in another area as well.

We already know that idiopathic pain is a major problem in chronic disease, and we know that the individual's ability to properly sense the world around them is damaged. From the Wellcome story:
"By associating a variant that affects the gene LRP1 with common migraines, this confirms that the glutamate signalling pathway is involved in the development of migraines," says Professor Aarno Palotie, Senior Group Leader at the Wellcome Trust Sanger Institute and one of the authors of the study."
(Aha - so that is why Wellcome press release didn't give us the warning about the lack of immediately usefulness of the study results -- they sponsored the study and had an interest in it being successful)

Monosodium glutamate was always a big no-no for me... Isn't this getting interesting now...

AFP adds more info:
Two of them, known as PRDM16 and TRPM8, were specific to migraines, as opposed to other kinds of headaches. TRPM8, in addition, was linked to migraines only in women. Earlier studies have shown that the same gene contains the genetic "blueprint" for a pain sensor, in both men and women. The third suspect gene, LRP1, is involved in sensing the external world and in chemical pathways inside the brain.
So I guess future researchers can look at TRPM8 with respect to idiopathic pain. I wonder if there are any bacterial genes with close homology (similarity) to the 'mutated' TRPM8?

And the possibility that LRP1 might lead to part of the answer for syndromes such as MCS (multiple chemical sensitivity) does intrigue me, as my migraines were often associated with an increased sensitivity to objectionable stimuli - mostly smells.

The Daily Mail further reports:
The intense headaches, which can  be accompanied by nausea and an acute sensitivity to light, may take up to three days to pass and are difficult to treat.
Oh? Photosensitivity isn't unique to people on the Marshall Protocol? :) :) :)

AFP: "The brain of a person with migraine responds differently to certain stimuli, their nerve cells 'talk' differently to each other," explained Shuerks in an email."

I think we can all agree with that... This team really does seem to 'have a clue...'

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