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Estrogen receptor seems to control Obesity
 Moderated by: Prof Trevor Marshall
 

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Prof Trevor Marshall
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 Posted: Wed Oct 5th, 2011 10:20

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Thanks to Bane for pointing out a new study
http://www.sciencedaily.com/releases/2011/10/111004123600.htm

which builds on the older report at:
http://www.sciencedaily.com/releases/2007/08/070820145348.htm

The experiments were done in mice, but the fulltext paper shows they were done very carefully. What is particularly interesting to me are two things

1. We already know that some of the components of the microbiota (eg EBV) downregulate the estrogen receptor (which in turn downregulates the VDR), and

2. The location specificity of the effect shows how difficult it is going to be to produce drugs which can selectively target harmful effects of the microbiota. As you would know, a drug in the bloodstream would perfuse both sets of tissues, those enhancing obesity and those reducing obesity.

It looks like we might be stuck with MP IP for some time (due to the complexity in the way the human body operates) :X And that a specific drug for obesity is going to be very difficult indeed to design :)

..Trevor..
 

wrotek
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 Posted: Thu Oct 6th, 2011 01:34

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So, that supports beer with it's phytoestrogens, makes U bigger :) ?

Last edited on Thu Oct 6th, 2011 01:53 by wrotek



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Cynthia S
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 Posted: Thu Oct 6th, 2011 07:27

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Seems it would be the opposite.  Women in menopause, lower estrogen, gain weight.  Wonder if lower testosterone in men has the same effect, and the phytoestrogens are some how upsetting the hormones.  Cynthia



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wrotek
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 Posted: Tue Oct 18th, 2011 10:56

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Makes sense
Is not it that all males should be slim and all females bigger ? Or the other way around ?:) Males have generally lower estrogen, right ?

I am slim.
So generally women should have different tendency to gain weight ?

Last edited on Tue Oct 18th, 2011 10:59 by wrotek



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Prof Trevor Marshall
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 Posted: Tue Oct 18th, 2011 11:14

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You are slim, Wrotek? You lucky guy :) :) :)
 

Markt9452
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 Posted: Tue Oct 18th, 2011 11:31

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Wrotek can you take some estrogen so we can see if you start getting chubby?



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wrotek
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 Posted: Tue Oct 18th, 2011 12:23

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Dr Marshall, Yes I am :D Always was. 190cm height and 90-96 Kilos weight.

Markt, I could take some phytoestrogens in beer :D
That would be quite pleasurable experiment at the beginning
Would definitively made me bigger, beer belly etc...

But probably phytoestrogens are not exactly working like estrogen... I guess they affect other nuclear receptors in a different way.

Last edited on Tue Oct 18th, 2011 13:10 by wrotek



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Marty.K
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 Posted: Tue Oct 18th, 2011 14:27

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lol, you guys are hilarious.

So the amount of estrogen doesn't really affect weight gain. It's just which or what location in the brain the estrogen receptor is knocked out.

The amount of estrogen would only affect the VDR. If the estrogen docks in there.



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NickBowler
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 Posted: Fri Apr 6th, 2012 05:56

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not exactly on topic, but obesity does increase breast cancer risk:

http://breast-cancer-research.com/content/14/2/R58/abstract



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Prof Trevor Marshall
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 Posted: Fri Apr 6th, 2012 09:09

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Or more strictly, the two conditions are co-morbidities :)

We need to put them on Amy and Paul's comorbidity wheel. Still, it's a bit too early to do that IMO :)
 

Sallie Q
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 Posted: Fri Apr 6th, 2012 14:51

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When I had breast cancer my skin had a greasy feel to it. When I could scratch some off under my fingernail, the appearance of the shed skin was greyish.

I suppose my estrogen started down the tubes 30 years ago when I went into early menopause.

Since MP my skin feels silky and shed skin is pinkish (most of my ancestors had very pale skin).

My oldest clothes are too loose, but I have put on weight although I do not appear obese.
Dictionaries have confusing and often circular definitions for this :?
I like the French 'embonpoint' = well rounded. Such diplomats :)



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Russ
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 Posted: Mon Apr 9th, 2012 03:46

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NickBowler wrote: not exactly on topic, but obesity does increase breast cancer risk:

http://breast-cancer-research.com/content/14/2/R58/abstract

Also a possible connection between a mother's weight and the likelihood that any futuree children she has will develop autism or another neurodevelopmental disorder...

http://thechart.blogs.cnn.com/2012/04/09/moms-weight-or-diabetic-condition-may-be-a-factor-in-autism/ 

Last edited on Mon Apr 9th, 2012 03:48 by Russ

scooker48
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 Posted: Mon Apr 9th, 2012 11:53

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And "Vitamin D" is a fat soluble substance. 

Sorry if this is redundant.

I will forever more think of it as "Vitamin Death".

Sherry



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Prof Trevor Marshall
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 Posted: Mon Apr 9th, 2012 12:15

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I like that idea Sherry. Maybe you will see it in one of my slides soon :) :)
 

Jermack
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 Posted: Tue Aug 21st, 2012 09:38

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Antibiotics may increase obesity in babies

http://www.msnbc.msn.com/id/48736968/ns/health-childrens_health/



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Prof Trevor Marshall
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 Posted: Tue Aug 21st, 2012 15:19

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Perhaps the babies were being given antibiotics because they were sick. And perhaps the sickness predisposed to obesity.

Just sayin...
 

wrotek
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 Posted: Tue Aug 21st, 2012 23:41

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There is a bear belly, recently we have wheatbelly...Apparently wheat is sprayed with insecticides and fungicides which resemble estrogen structure. So they probably work like analogs.

Glutenology video touches this subject
http://www.glutenology.net/glutenology-health-matrix-free-video/ 

Last edited on Tue Aug 21st, 2012 23:45 by wrotek



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