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Minocycline is an excellent Anti-inflammatory
 Moderated by: Prof Trevor Marshall Page:  First Page Previous Page  1  2  3  4  5  Next Page Last Page  
 

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mvanwink5
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 Posted: Sun Feb 19th, 2012 05:34

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Jigsaw,
My experience is when I stop Minocycline that IP immediately increases, and this is even when it is being dosed q48h. Indeed, common cohort experience is that reduction of Minocycline must be done slowly and such dose reduction is commonly termed "weaning." From this experience, it seems to me the simple description of what is happening with Minocycline's mode of action as one of interfering with pathogen chemical machinery is missing essential and prominent subsurface biochemistry that looks a lot like immunosuppression hidden by other immune action (perhaps such as interference with the PXR). So, what is really happening to the pathogens and the immune system is unclear, at least to my fogged mind. It just seems to me that with all this cellular biochemical attempts at self regulation that the less tinkering, the easier it may be for the immune system to reestablish itself as perhaps it should function.

It just seems to me that if it is possible to keep intervention simple, then unintended dramas might be avoided (such as heavy stage 5). Just some thoughts, perhaps just wishful thinking.

Best regards,
Mike

Last edited on Sun Feb 19th, 2012 07:21 by mvanwink5



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jlunn247
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 Posted: Mon Feb 20th, 2012 00:04

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I avoid mino or any abx as it has done its job well enough.
Although i have yet to try using less as in the beginning.
Anybody got any time release micro dose mino?
Use a calcium buffer? and a grain of salt?:)
M -A dommergues http://www.ncbi.nlm.nih.gov/pubmed/14568022

Last edited on Mon Feb 20th, 2012 05:38 by jlunn247



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Bane
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 Posted: Thu Mar 1st, 2012 21:15

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Scientists shocked to find antibiotics alleviate symptoms of schizophrenia

http://tiny.cc/671jf

"The National Institute for Health Research is funding a £1.9m trial of minocycline, which will begin recruiting patients in the UK next month. The research follows case reports from Japan in which the drug was prescribed to patients with schizophrenia who had infections and led to dramatic improvements in their psychotic symptoms"

Joyful
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 Posted: Sat Mar 3rd, 2012 17:53

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The use of minocycline to lower inflammation for schizophrenia is interesting.

My own recent experience with frequent minocycline is similar to my experience at the beginning of the MP. When I take 100mg dosing the neurological symptoms (similar to what is commonly known as migraine) are very strong. My whole nervous system feels on edge. Insomnia is a real problem. The frequency of dosing does not change this effect. If I lower the dose to 50mg, at any frequency, these symptoms fade within a few days.



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pgeek
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 Posted: Sun Mar 4th, 2012 04:32

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Joyful wrote:
When I take 100mg dosing the neurological symptoms (similar to what is commonly known as migraine) are very strong. My whole nervous system feels on edge. Insomnia is a real problem. The frequency of dosing does not change this effect. If I lower the dose to 50mg, at any frequency, these symptoms fade within a few days.

I think we're going to have a really hard time explaining/understanding that!



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Joyful
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 Posted: Thu Mar 8th, 2012 22:35

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Man, if I had to have an explanation for everything I've experienced on the MP,
I would have lost it years ago. ;)



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seanlane
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 Posted: Sat Mar 10th, 2012 06:58

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Minocycline prevents impaired glial glutamate uptake in the spinal sensory synapses of neuropathic rats.


http://www.ncbi.nlm.nih.gov/pubmed/20678556


Minocycline treatment inhibits microglial activation and alters spinal levels of endocannabinoids in a rat model of neuropathic pain

http://www.molecularpain.com/content/5/1/35


Whats up with the glial, glutamate, and minocycline?

Last edited on Sat Mar 10th, 2012 07:01 by seanlane



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Prof Trevor Marshall
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 Posted: Sat Mar 10th, 2012 07:58

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Whats up with the glial, glutamate, and minocycline?
you forgot to ask about the cannabinoids :) :)
 

pgeek
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 Posted: Sat Mar 10th, 2012 08:05

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Dr Trevor Marshall wrote:
Whats up with the glial, glutamate, and minocycline?
you forgot to ask about the cannabinoids :) :)

I think we can handle hearing about the cannabinoids ;)



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ChrisMavo
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 Posted: Sat Mar 10th, 2012 14:15

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Because mino seems to damp down the glial action in the CNS ... would it be a good idea for me to start taking mino again?  I have read of MS patients who get some relief from taking mino. 



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Joyful
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 Posted: Sat Mar 10th, 2012 18:54

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I don't know Chris. I know that for me a certain dose puts me "on edge" and the lower dose doesn't seem to "do" anything.

If I wasn't tinkering with other factors, I might experiment with frequent 50mg dosing again.



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 Posted: Sun Mar 11th, 2012 11:14

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Chris did you get some palliation from Mino in the past?  I think that would probably be the best predictor of how you might respond now.

I recently embarked on Q24 hour 50 mg Mino, to make sure my immune system noticed any new microbes I might have gotten along with a new tick bite.  I made it through just two doses, with IP well into the intolerable range and escalating, and quit the Mino after that.  But I have a history of being unable to tolerate Mino on a continuing basis.  Every few months I try again, to see where things are at.

All best to you my warrior friend,
Dody



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ChrisMavo
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 Posted: Sun Mar 11th, 2012 13:39

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Thanks Dody.  I really have not felt any difference when taking mino in the past.  If it does down modulates the glial in the CNS ... that could be good or bad depending on how you look at it.  A weakened glial response would stop some loss of neurons.. but that might slow eventual recovery.  Like always .... this is a balancing game ... trial and error being the order of the day for us MP pioneers!  But, I may try taking some mino along with the Volvic water to see if it lessens the IP I am getting from the water.

Good health! 



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Bane
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 Posted: Tue May 1st, 2012 13:40

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Bane wrote: Scientists shocked to find antibiotics alleviate symptoms of schizophrenia

http://tiny.cc/671jf

"The National Institute for Health Research is funding a £1.9m trial of minocycline, which will begin recruiting patients in the UK next month. The research follows case reports from Japan in which the drug was prescribed to patients with schizophrenia who had infections and led to dramatic improvements in their psychotic symptoms"

Minocycline benefits negative symptoms in early schizophrenia; a randomised double-blind placebo-controlled clinical trial in patients on standard treatment.

http://www.ncbi.nlm.nih.gov/pubmed/22526685

"The addition of minocycline to TAU early in the course of schizophrenia predominantly improves negative symptoms. Whether this is mediated by neuroprotective, anti-inflammatory or others actions is under investigation"

Bane
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 Posted: Mon May 28th, 2012 11:28

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Efficacy of combination oral antimicrobial agents against biofilm-embedded methicillin-resistant Staphylococcus aureus.

http://www.ncbi.nlm.nih.gov/pubmed/22572005

"The activity of minocycline was concentration-dependent and more effective against MRSA isolates that demonstrated weak biofilm formation. The effect of minocycline seems to be further enhanced when used in combination with either fusidic acid or linezolid at low concentrations, with the obtained results equal to those obtained with rifampicin-based regimens (p<0.001). Rifampicin plus minocycline was also effective against MRSA in biofilm"

Prof Trevor Marshall
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 Posted: Mon May 28th, 2012 16:35

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They are still drawing conclusions from in-vitro work. Bad habits die slowly, I guess...

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 Posted: Fri Jul 20th, 2012 03:51

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Bane wrote:Does minocycline, an antibiotic with inhibitory effects on microglial activation, sharpen a sense of trust in social interaction?

http://www.ncbi.nlm.nih.gov/pubmed/21956241

METHODS:Forty-nine healthy volunteers were administered minocycline or placebo over four days, after which they played (1) a trust game, in which they decided how much to trust an anonymous partner, and (2) a dictator game, in which they decided how to divide resources between themselves and an anonymous partner.

CONCLUSIONS:These results suggest that minocycline led to more rational decision-making strategies, possibly by increasing emotion regulation. Since minocycline is a well-known inhibitor of microglial activation, our findings may open a new optional pathway for treating mental states in which a component of rational decision making is impaired.

Minocycline modulates human social decision-making: possible impact of microglia on personality-oriented social behaviors.

http://www.ncbi.nlm.nih.gov/pubmed/22808165

CONCLUSIONS/SIGNIFICANCE: Our results suggest that minocycline led to more situation-oriented decision-making, possibly by suppressing the effects of personality traits, and furthermore that personality and social behaviors might be modulated by microglia. Early-life events may activate human microglia, establish a certain neuro-synaptic connection, and this formation may determine each human's personality and personality- oriented social behaviors in later life. To explore these mechanisms, further translational research is needed.

madwolf
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 Posted: Mon Jul 23rd, 2012 08:56

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What about mino in bipolar dz?  Is there any relation there?  How about in narcolepsy?  I just finished a thread about that that pulled some of my strings.

My stepson has bipolar dz, but it is seasonal.  As spring approaches, he becomes manic, as fall and winter approaches, he retreats into his cave with depression.  He is "controlled" on Zyprexa, but that is not a real solution.

I have a dx of sleep apnea, use a CPAP faithfully, but still fall asleep if I am not stimulated.  Is narcolepsy a consideration?

I'm only doing Benicar qid now, but am giving some thought to giving the mino another try.

Last edited on Mon Jul 23rd, 2012 08:57 by madwolf



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 Posted: Mon Jul 23rd, 2012 09:10

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Hey, Madwolf, have you had a look at our YouTube channel recently? You might be interested in Titta's presentation at the Singapore conference:

http://www.youtube.com/watch?v=3PL8f3aCZCU

and my most recent presentation:

http://www.youtube.com/watch?v=_rFmAMDdbjs

They cover many of these topics :)

..Trevor..
 

mvanwink5
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 Posted: Mon Jul 23rd, 2012 11:15

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Since minocycline is a well-known inhibitor of microglial activation
This was a disturbing comment that the paper makes about minocycline, at least in my thinking.

Best regards,
Mike



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