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The Marshall Protocol Study Site > PROF. MARSHALL'S PERSPECTIVE > Prof. Marshall's Perspective > Our new paper for free from 'Current Opinion in Rheumatology'


Our new paper for free from 'Current Opinion in Rheumatology'
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Prof Trevor Marshall
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 Posted: Sat Feb 2nd, 2013 22:26

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Our new paper "The Human Microbiome and Autoimmunity" has been published by "Current Opinion in Rheumatology," and made available for free distribution online. You can view, or download a free PDF of it, from:

http://goo.gl/qrxVH
or
http://journals.lww.com/co-rheumatology/Fulltext/2013/03000/The_human_microbiome_and_autoimmunity.14.aspx
-----------
Note: The fulltext is no longer free, but you can get a preprint from our own server at:
http://autoimmunityresearch.org/preprints/Proal_2013_CurrentOpinion-Preprint.pdf

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The pathogenesis we describe is equally applicable to all the syndromes resulting from microbiome dysbiosis.

I am hoping that the simplified format we used in this (relatively short) paper will make the science accessible to everybody, and the publisher deciding to make the  fulltext available for free is an added bonus for us all.

Note particularly the section on failing in Human Genetic analysis leading to an excess of SNPs, and the citations which the reviewers tagged as particularly important.

Please print out a copy to give to your friends, family, and Doctor(s).

Sincerely
Trevor

Nyima
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 Posted: Sun Feb 3rd, 2013 00:24

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A comprehensive, accessible and well referenced paper - congratulations:dude::dude::dude:



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MP start Dec 10 (2 mo. break Jan-Mar '11) | Multinodular thyroid | frequent illness| fatigue | brain-fog | gluten intolerance (poss coeliac), eczema with dairy products | 25D (ng/ml): 4(14 Apr 11), 5.3(26 Apr 13), 4(Jan 14), 5.5(July 14)
David_in_UK
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 Posted: Sun Feb 3rd, 2013 02:59

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Excellent work and very useful. Congratulations to all involved.



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MP start May'12 (no breaks) | CFS | fatigue, depression | IBS | probable AS | last 25D=9 ng/ml Feb 2016
GillyB
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 Posted: Sun Feb 3rd, 2013 06:28

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Great paper, I will share it around.

Sadly, same issue of this journal:
Vitamin D deficiency and risk for rheumatic diseases: an update
I'm sure you can guess what it says.  *facepalm*



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MP start Jun'12, once again on an MP break | Degenerative Disc Disease, Osteoarthritis, Post-Lyme, depression/anxiety, GI. Most recent serum 25D: 6/15 -18
Carry on, and keep MP'ing
mvanwink5
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 Posted: Sun Feb 3rd, 2013 06:31

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Dr. Marshall,
You and your team keep getting better and better. Thank you all for the ground breaking work. I don't remember seeing the abstract on AAAS Breaking News EurekAlert! It should be. Also, what about the other science news sites?

Best regards,
Mike

http://nextbigfuture.com/

etc.

PS Dr. Marshall, you need a California eeGeek fashion consultant to dress like those jean wearers, that way you will be taken as a serious laid-back, cutting edge, big idea paradigm buster. You do live in California. Just kidding, keep doing the great work with your team.

Last edited on Sun Feb 3rd, 2013 07:33 by mvanwink5



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Cynthia S
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 Posted: Sun Feb 3rd, 2013 07:15

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I guess I stand corrected on my email to moderators and company, implying that the MP team were the source of the comments in the references.  But that means that the reviewers did what I would describe as a double take on the work.  Maybe one of the major values of this paper is what it is achieving with the reviewers in addition to what I hope will be plenty of doctors and researchers reading it.  Cynthia



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MP start 10/08,break 1/16 - 9/16, Spondylitis'97,early Diverticulosis'98,early AMD'08,Calcium anomaly'95,TypeII Diabetes(?)'02,Degenerative hip disease'12, 25D=10.8 May'18 (preMP 125D/25D=47/43) https://marshallprotocol.com/forum30/13911-2.html
mvanwink5
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 Posted: Sun Feb 3rd, 2013 07:25

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Cynthia,
Corrected or not, it got me to look at the references earlier than I would have. Further, your point that the reviewers or someone really took the time to digest the paper rang true and significant. Such time investment is, I suspect, rare (maybe it isn't among researchers, what do I know?).

Best regards,
Mike



____________________
Lyme joints, EMF sensitive, MP start 8/10; 25D <4ng/ml 6/19; vegetarian; olmesartan only-240mg/d, RF shielding required, My Progress: http://tinyurl.com/z2stwo8
Cynthia S
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 Posted: Sun Feb 3rd, 2013 07:40

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Dr. Marshall, I spent a couple mornings trying to find an analysis of the Iowa Womens Health Study(IWHS) that use more than 4 years of data in the analysis of the effects of vitamin D.  That study of nearly 40,000 women had gone on for 22 years last time I check, and may be still on going.  The only paper I could find using more than 4 years of data was one that used 7 years of data.  And yet I recall a letter, critical of some aspect of a paper that was published involving vit D, that suggested that the IWHS showed no value to vit D at 10 years and that it was detrimental at 15 years.

The purpose of my search had been to find the study that showed this detrimental result from the IWHS data.  Maybe I am just not that good at searching scientific studies.  Or maybe the scuttle butt going around is that such data is there, but no researcher wants to be the one to say 'the emperor has no clothes' and put his standing in the scientific community at risk.  One researcher who published the results for only 4 years worth of data actually said in his paper that he did not trust the data beyond 4 years.  This is a great euphemism for 'the data did not give me the answer I wanted'.  No institution is going to follow nearly 40,000 women for 22 years and do it carelessly.  He was clearly mining the data, but if you accused him of that he would undoubtedly vehemently deny such a thing.

So, if no researcher has the guts to publish an analysis of 15+ years of the data from the IWHS for vit D, maybe your team could do it.

Cynthia



____________________
MP start 10/08,break 1/16 - 9/16, Spondylitis'97,early Diverticulosis'98,early AMD'08,Calcium anomaly'95,TypeII Diabetes(?)'02,Degenerative hip disease'12, 25D=10.8 May'18 (preMP 125D/25D=47/43) https://marshallprotocol.com/forum30/13911-2.html
Rico
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 Posted: Sun Feb 3rd, 2013 08:00

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Style of writing reminds me a bit of the bacteriality site. Easy to read and understand.  Good work!



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No diagnosis/some symptoms (more than I knew); wife with Sarc on MP; Olm 40mg q4-6h | 25D=22 (May 2014) | 25D=27 (Nov 2014)
Prof Trevor Marshall
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 Posted: Sun Feb 3rd, 2013 10:16

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"So, if no researcher has the guts to publish an analysis of 15+ years of the data from the IWHS for vit D, maybe your team could do it"

But we don't have access to the data, Cynthia :)
 

Frenchie
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 Posted: Mon Feb 4th, 2013 01:32

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Cynthia Schnitz wrote: One researcher who published the results for only 4 years worth of data actually said in his paper that he did not trust the data beyond 4 years.  This is a great euphemism for 'the data did not give me the answer I wanted'.

When examining reasons for the low profile of negative results publications, one common assumption is that publishing negative results might harm scientists’ reputations. Along these lines, negative results are believed to indirectly communicate to the scientific community that a study was poorly designed and researchers were either unknowledgeable about the phenomenon or incapable of tailoring more robust research hypotheses. Moreover, the discouragement to submit publications reporting negative results is due to a higher likelihood that these papers will be filtered by the peer-review firewall, given their perceived lack of soundness in comparison to studies with “successful” results.

http://blogs.biomedcentral.com/bmcblog/2012/10/10/no-result-is-worthless-the-value-of-negative-results-in-science/

Negative data have always been harder to disseminate, yet ostensibly insignificant results can sometimes lead to a paradigm shift. One noteworthy example is that of Albert Michelson and Edward Morley, two 19th-century physicists, who performed a series of experiments to detect the relative motion of matter through the “luminiferous aether”—a theoretical medium thought to carry light waves. Despite the fact that their negative results clearly contradicted the theory of stationary aether, the scientific community initially overlooked them. It was only when they eventually published their findings in the American Journal of Science in 1881 that the prevailing theory was questioned, thereby opening up a line of research that ultimately led to Einstein’s special theory of relativity.


http://www.the-scientist.com/?articles.view/articleNo/33968/title/Opinion--Publish-Negative-Results/

There have also been efforts recently to try to get more raw data published:

The study also found that researchers rarely volunteer data. Of all 500 papers analyzed, only 47 had their full primary data sets -- rather than just the raw data specifically requested by the journals -- publicly available. None of the papers published in journals without data-sharing policies deposited their full set of raw data online.
The results echo those of a July study that also found data-sharing practices wanting. That study, led by Heather Piwowar, a bioinformatics researcher at the University of British Columbia in Vancouver, examined more than 11,000 gene expression studies published between 2000 and 2009. Of those, the percentage that had raw data available online increased from less than 5% in 2001 to 35% in 2009.
Ioannidis and Piwowar says that more journals should adopt data-sharing policies and ensure that scientists consistently follow the rules. "You need an extra editorial office and maybe more," says Ioannidis.
Piwowar speculates that journal editors shy away from introducing data-sharing policies for fear of deterring submissions. "Journals can get away with not having policies because it is not yet generally regarded as the norm," she says.
Steven Wiley, director of biomolecular systems at the Pacific Northwest National Laboratory in Richland, Washington, says the current study does not address the question of why scientists might defy data-sharing policies. Sharing data "is time-consuming to do properly, the reward systems aren't there and neither is the stick", he says.She urges editors in each field to come together to implement policies simultaneously, as was done with several evolution journals in January 2011 under an NSF funded initiative called the Joint Data Archiving Policy.

http://www.scientificamerican.com/article.cfm?id=researchers-failing-to-make-data-public



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Cynthia S
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 Posted: Mon Feb 4th, 2013 08:03

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I just received this by email, and it does show at least no benefit from vit D in the Iowa Womens' Health Study.   It also indicates three questionnaires, period between being at 11 years and then 18 years from first questionnaire.  So the data on supplements was on these three occasions, but the deaths appeared to be collected continuously thru public records.  So, mortality was the main result of interest for the Study.
http://archinte.jamanetwork.com/article.aspx?articleid=1105975

Sorry from diverting this thread, so, please carry on.  Any comments on this subject should probably be in another thread.

Cynthia

 



____________________
MP start 10/08,break 1/16 - 9/16, Spondylitis'97,early Diverticulosis'98,early AMD'08,Calcium anomaly'95,TypeII Diabetes(?)'02,Degenerative hip disease'12, 25D=10.8 May'18 (preMP 125D/25D=47/43) https://marshallprotocol.com/forum30/13911-2.html
Gerard
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 Posted: Mon Feb 4th, 2013 08:51

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Thanks for the excellent work.
 
I will give the paper to my family doc tomorrow. I have to convince him to keep supporting me.
He said it was irresponsible to continue with OM.

So I hope it helps.
GeraRD



____________________
MP start Jan'11 (no breaks) | rhinitis'78, sinusitis'78, COPD'82, asthma'82, eyes CSC left'86/right'99, hypertension,'99 hypercholesterolemia'03, legs varicose veins'03, tinnitus'05, hearing loss'05, BPH'06 | last 25D= 6 ng/mL Oct.2012
Prof Trevor Marshall
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 Posted: Mon Feb 4th, 2013 09:12

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Gerard, you might also print out Dr Greg Blaney's presentation in Slovenia. That is pretty straightforward - OM works, and the dosing is safe:

http://autoimmunityresearch.org/abstracts/Ljubljana_Blaney_transcript.pdf

..Trevor..
 


Gerard
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 Posted: Tue Feb 5th, 2013 11:05

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Thanks,
I will do.
Gerard



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MP start Jan'11 (no breaks) | rhinitis'78, sinusitis'78, COPD'82, asthma'82, eyes CSC left'86/right'99, hypertension,'99 hypercholesterolemia'03, legs varicose veins'03, tinnitus'05, hearing loss'05, BPH'06 | last 25D= 6 ng/mL Oct.2012
Paisleykilt
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 Posted: Tue Feb 5th, 2013 12:59

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-Loved this paper and have sent it to my doctors, kid (studying bio-medical engineering), husband, and friends.  It explains why I'm doing what I'm doing so much better than I can.  Thank you!

Frenchie, I also sent your post re the value of negative results to aforementioned son, because he hopes to become a researcher and pondering/recognizing these things is important.  Thank you, too! 

:cool:



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"Life is a whim of several billion cells to be you for a while." Groucho Marx.
MP start May'11 (2 breaks: one in December '15 and one Jan-Mar '18) | Lyme Disease '93, CFS/ME '10 | muscle/joint pain, severe fatigue, myriad neurological symptoms
be-well
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 Posted: Wed Feb 6th, 2013 13:54

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Yes indeed...many congratulations on this very important piece of work.



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mcs,chronic fatigue,hiatus hernia,osteopenia, polycystic liver,grains intolerance,tinnitus,photosensitivity.
|25-D-3.3.-1,25D-58. 25-D-3.3.- 1,25D-70.Dec 2014.
wrotek
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 Posted: Mon Feb 11th, 2013 01:38

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I dont think the paper is available in full version anymore.



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Borreliosis(4 strains),Bartonella IgG only, reflux,headache TMJD ,chronic pain,chronic fatigue,depression 125D36 Ph1Sep05 Ph2Oct06 Ph3Apr07 in low lux NoIRs 25D<7 Oct06
Prof Trevor Marshall
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 Posted: Mon Feb 11th, 2013 03:30

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Wrotek,
I just tested the two links (above) and could download the PDF OK. So I tried again from Germany and also from the United Kingdom. As of this morning, it is at least still available in fulltext from those three countries :) Try to access it again :)

..Trevor..

wrotek
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 Posted: Mon Feb 11th, 2013 04:07

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Dr Marshall
It works now, before there was a need to register or buy the article, in both links.

Last edited on Mon Feb 11th, 2013 04:08 by wrotek



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Borreliosis(4 strains),Bartonella IgG only, reflux,headache TMJD ,chronic pain,chronic fatigue,depression 125D36 Ph1Sep05 Ph2Oct06 Ph3Apr07 in low lux NoIRs 25D<7 Oct06

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