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The Marshall Protocol Study Site > PROF. MARSHALL'S PERSPECTIVE > Prof. Marshall's Perspective > Our new paper for free from 'Current Opinion in Rheumatology'


Our new paper for free from 'Current Opinion in Rheumatology'
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wrotek
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Joined: Thu Dec 30th, 2004
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 Posted: Sun Feb 17th, 2013 05:05

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"Kusaliket al. [44] found that
19 605 pentamers from the hepatitis C virus (HCV)
polyprotein have a high level of similarity to the
human proteome. "

Does pentamer from hepatitis C mean chain of 5 amino acids ?



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Prof Trevor Marshall
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 Posted: Sun Feb 17th, 2013 05:12

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Yes, that is what it means. I personally think pentameric similarity is a meaningless measure, the underlying science is obvious enough to me. But scientists these days seem to need measures to help them grasp the underlying concepts :) So the pentamer is a form of "proof," I guess :)



mvanwink5
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 Posted: Sun Feb 17th, 2013 05:16

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wrotek,
wiki gives four alternate suggestions one of which has a viral reference, but without the article direct context it would be a guess.
http://en.wikipedia.org/wiki/Pentamer
These two might fit:

In biochemistry, it applies to macromolecules, in particular to pentameric proteins, made of five proteic sub-units.

In microbiology, a pentamer is one of the proteins composing the polyhedral protein shell that encloses the bacterial micro-compartments known as carboxysomes.

Best regards,
Mike



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Prof Trevor Marshall
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 Posted: Sun Feb 17th, 2013 05:20

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I haven't had time to look at this particular paper, but in the context of protein similarity, pentamer is the term given to chains of 5 amino acids, which are almost always sub-chains of the much larger protein.

It is a meaningless measure, IMO. But if you need real numbers to hang your hat on, I guess it is 'any port in a storm' :)

jrfoutin
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 Posted: Thu Feb 21st, 2013 16:29

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Enjoyed article.

I hope more researchers focus on immunopathology. That seems to be the medical big bang game changer for the future of the standard of care.

Thank you team for continuing to point in the direction research needs to go.

Just noticing your leadership and how perspectives about D, murine, microbiome and a whole lot more are slowly but surely evolving because of your voice in the industry. Please continue.

Best to all--Janet



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