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Azithromycin Poses Fatal Cardiac Risk, FDA Warns
 Moderated by: Prof Trevor Marshall
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Prof Trevor Marshall
Foundation Staff


Joined: Fri Jul 9th, 2004
Location: Thousand Oaks, California USA
Posts: 15811
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 Posted: Tue Mar 12th, 2013 13:38
Well, maybe not my worst fears. But still, in 2008 I decided that Azithromycin was emerging with too many potential biochemical risk factors, and too little benefit, to continue using it as part of the MP.  This decision was based on the degree of interaction between the drug and Homo sapiens. So its affecting cardiac health is not a surprise to me.

http://www.fda.gov/Drugs/Drugsafety/ucm304372.htm

As I said in 2008, I see no evidence that antibiotics play any significant part in the recovery induced by Olmesartan.

MPKB still suggests Minocycline for palliation and pulsing of symptoms, but over the next few weeks I hope to be able to make an announcement that we have identified a better palliative drug than minocycline.

A number of antibiotics are suggested on our ER guidance, which can be used for acute infections which will occur from time to time as part of our recoveries.
 
 

Last edited on Wed Mar 13th, 2013 02:51 by Prof Trevor Marshall

wrotek
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Joined: Thu Dec 30th, 2004
Location: Wroclaw, Poland
Posts: 2939
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 Posted: Wed Mar 13th, 2013 02:24
So, it is not immunopathology causing heart problems ?
I thin i experience that mine symptoms increase significantly after minocycline, not decrease.

Last edited on Wed Mar 13th, 2013 02:39 by wrotek



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Lyme reflux chronic pain fatigue depression 125D36 Ph1Sep05 Ph2Oct06 Ph3Apr07 in low lux NoIRs 25D<7 Oct06
Prof Trevor Marshall
Foundation Staff


Joined: Fri Jul 9th, 2004
Location: Thousand Oaks, California USA
Posts: 15811
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 Posted: Wed Mar 13th, 2013 02:28
Each of the MP antibiotics exert profound changes in human biology. Both Minocycline and Clindamycin have been reported as PXR agonists, I have confirmed Minocycline in-silico.

The PXR receptor is in Figure 1 of my Bioessay, at the heart of the Vit-D metabolism. It is also at the heart of the xenobiotic mechanisms of the body, which is the X in PXR.

I have been working on alternatives for palliation for some years now, and am within weeks of making an announcement which should finally put this issue behind us, I hope...
 

Bella
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Joined: Sat Aug 27th, 2005
Location: Ask Me, USA
Posts: 2080
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 Posted: Wed Mar 13th, 2013 12:50
Can't wait to hear the news!!



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MP Break (5years) | CFS'92 | Fatigue | 25D=7 Dec. '13
Kas
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Joined: Wed Dec 8th, 2004
Location: Markham, Ontario Canada
Posts: 1127
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 Posted: Fri Mar 15th, 2013 05:05
After I added the smallest dose of zith to my two abx regime a few years back, my kidney function, which as excellent, deteriorated to stage 3CKD, and has never rebounded. Could zith ( together with mino and bactrim ) have caused this? Just wondered...



____________________
Sarc Dx by splenectomy 03- Lungs, lymph nodes, liver, later in kidneys. Anemia. Started MP 2004. Non- stop now since 2007. No abx since March 2008.Olmetec only. Natural progesterone cream one daily x 3 weeks a month; cal / mag supplement. B12 when levels
mvanwink5
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Joined: Fri Nov 5th, 2010
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 Posted: Fri Mar 15th, 2013 06:17
Dr Trevor Marshall wrote:
I have been working on alternatives for palliation for some years now, and am within weeks of making an announcement which should finally put this issue behind us, I hope...

Does it involve the CB1, CB2 receptors?



____________________
Lyme joints, EMF sensitive, MP start 8/10; 25D <4ng/ml 6/19; vegetarian; olmesartan only-240mg/d, RF shielding required, My Progress: http://tinyurl.com/z2stwo8
Prof Trevor Marshall
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Joined: Fri Jul 9th, 2004
Location: Thousand Oaks, California USA
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 Posted: Fri Mar 15th, 2013 08:14
@KAS  Probably just coincidence. Kidney bloodwork values are typically poor on the MP without any abx. Kidneys are strong however, just the bloodwork is a poor indicator once VDR is activated

@MVANWINK5  No

Kas
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Joined: Wed Dec 8th, 2004
Location: Markham, Ontario Canada
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 Posted: Fri Mar 15th, 2013 11:07
Thanks, Trevor, and good to know.

Abdominal ultrasound yesterday still showed stable enlarged peripancreatic lymph node. but healthy looking normal kidneys, liver and pancreas, with no evidence of any fatty disease, which had been seen in the earlier days of the MP.

Despite my low hemoglobin level, I feel great! The MP has allowed me to live a full and busy life, and no one even believes I have an illness these days! Still working part- time, exercising moderately, studying, travelling from time to time and socially very active. Weight excellent and being maintained ( 120 lbs and 5'2', size 6'), pre - diabetes stable and in the normal range unless I misbehave! Digestive problems on G-F diet , day and night from before. BP always low, but never an issue these days, and I hardly ever take it. In the doc's rooms once a month, it is often around 80/50. If I feel fine, the numbers are unimportant to me,

So, thank you so much for the MP, and for the fact that I am proof that even if your blood work is far from perfect, you can still be well and enjoying life. I think I may stay on olmetsartan for life at this rate!!



____________________
Sarc Dx by splenectomy 03- Lungs, lymph nodes, liver, later in kidneys. Anemia. Started MP 2004. Non- stop now since 2007. No abx since March 2008.Olmetec only. Natural progesterone cream one daily x 3 weeks a month; cal / mag supplement. B12 when levels

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