Tramadol: hardly ever. I've had a script for it for long time, but never found it(very) effective, so used it little. Did find in 2009 with broken leg that it helped leg pain. But that was a long time ago by now.
Hmm. well its not that, then. When friends are struggling I usually scan the 'usual culprits' - non-MP drugs, supplements, therapies food, high Vit D levels, etc - in the hope something obvious will pop up.