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Our Definitive Paper on CFS / ME is Published
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Prof Trevor Marshall
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 Posted: Sat Apr 13th, 2013 09:05

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Our new paper, "Immunostimulation in the treatment for chronic
fatigue syndrome/myalgic encephalomyelitis", has been peer-reviewed and published by Springer's 'Immunologic Research.'

You can download a preprint of the paper from our website:

http://AutoimmunityResearch.org/preprints/2013-Lindseth-ImmunologicResearch.pdf

Links to the PubMed and Springer pages:

http://www.ncbi.nlm.nih.gov/pubmed/23576059
http://link.springer.com/article/10.1007%2Fs12026-013-8413-z

Don't forget the Transcript of Inge's presentation at the International Congress on Autoimmunity, which formed the basis for this publication, but makes a more patient-friendly read:

http://autoimmunityresearch.org/transcripts/Auto2012_IngeLindseth.pdf

And Inge's YouTube presentation:

http://www.youtube.com/watch?v=2IMdAV6SIMU

Thanks to all who helped us get our efforts to this point, for helping us build a solid basis for moving forward into mainstream consciousness.

..Trevor..

leroybrown
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 Posted: Sat Apr 13th, 2013 11:50

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I am working my way through the 22 pages! I'm on page 7. Congratulations on the paper.

Deb



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I just know that something good is going to happen
And I don't know when - Kate Bush
Aplastic anemia Apr/10, PRCA Jan/09, Agranulocytosis 1991
25D = 25 1,25D = 58 Aug 18/09|25D<4.8 Mar/10|10.8 Nov/12
Sep '09 q8h Nov '09 q6h
k
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 Posted: Sat Apr 13th, 2013 14:44

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Awesome! Congrats!



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CFS menorrhagia & dysmenorrhoea anxiety depression paxil 600mg calcium daily Ph1.Oct07 Ph2.Feb08 Ph3.Sept08 BeniOnly.Aug09 MinoRestart.Dec09 25D=50(Jul07)23(Oct07)13.2(Jan08)12.8(Oct08)10(Sept09)12.8(Jun10)12.4(May11)8.3(Apr12) 4.4(Jun13) <4(Nov14)
jezzer
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 Posted: Sun Apr 14th, 2013 03:17

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And from me too:)



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MP start October 2010 (no breaks). HYPOTHYROID + CFS for 25 years. key symptoms = fatigue, brain fog & lack of motivation. Olmesartan = 40mg Q6 hours. 25D - no recent test. Home EMF = -55dB, shielded area approx -75dB.
mvanwink5
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 Posted: Sun Apr 14th, 2013 03:26

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Dr. Marshall,
Two points:
1. From my recent 25D serum level drop to 12 ng/ml it feels like 25D is not a mild immune suppressor. I can see at higher dosing, after the VDR is blocked or significantly disabled, that it would appear as a mild immune suppressor, but at the onset of engaging as an antagonist it would seem to be as powerful as any immune suppressing drug. Also given the very high affinity 25D has for the VDR, how can it not be seen as a dangerous drug?

2. It would seem to me that perhaps there are two elephants in the VDR room with stem cell proliferation and differentiation being the second elephant to the innate immune function of pathogen detection and destruction. With that in mind, perhaps the stem cell flow on effect is the more deadly and diabolical consequence of the intracellular pathogen survival tactic of shutting down the VDR. So, given that, auto immune disease perhaps should be viewed as a stem cell disease as well as an innate immune dysbiosis. In future papers, would it be possible to bring out the dangerous stem cell connection?

I realize from a treatment point of view, the restoration of the innate immune system efficacy is the spear tip, but a clear redirection of palliation regimen mind set from "feel good" to the danger to stem cell viability should finish off the discussion of suppression vs stimulation. That is just my thinking though.



____________________
Lyme joints, EMF sensitive, MP start 8/10; 25D <4ng/ml 6/19; vegetarian; olmesartan only-240mg/d, RF shielding required, My Progress: http://tinyurl.com/z2stwo8
Prof Trevor Marshall
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 Posted: Sun Apr 14th, 2013 04:27

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Mike,
Yes, as I said in the webconference yesterday, supplementation with Vitamin D may finally allow the world to see the stupidity of running evidence based experiments while lacking the underpinning scientific knowledge of what to measure. I fear that supplementation with Vitamin D will prove the biggest mistake that Medicine has ever made. Fortunately, I do see some pulling back of enthusiasm for high dose supplementation at this moment, and we must hope that not too much damage has been done. Additionally, the moves in Europe and Russia toward preventative and predictive medicine has  given us the tools needed to deal with a population potentially made very ill by the supplementation fad.

And yes, it is a very effective immunosuppressant. We can see that in many of the study results.

Medicine routinely uses immune suppression to try and help patients with idiopathic inflammatory disease. It is regarded as a "good thing" by physicians who have been given nothing else (by PhRMA) to help chronically ill patients. To try and completely wipe out that mode of thinking at this time is beyond our reach. I want to put in place the understanding of what to do next, and that is the reason for my PPPM efforts. You will see that coming through clearly in the Chapter we have just written for PPPM textbook which will be presented in Brussels in September.

..Trevor..

mvanwink5
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 Posted: Sun Apr 14th, 2013 04:52

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Dr. Marshall,
I fully realize I am re-preaching from the choir. The point is that it is the initial 25D dietary inclusion that does the damage. Afterwards, 25D looks like a mild or "safe" palliator. The second point will likely require published results on the stem cell issue, but disabling stem cells is not a small consequence of disabling the VDR from a disease, patient consequence point of view. Again, you are the one that mentioned in passing that the VDR expresses the Lrg4 and Lrg6 genes, crucial to stem cell viability. Is there a paper that shows this connection of the VDR to expression of Lrg4 and Lrg6, that you could point to (that is not pay walled) as I would like to read it?
As always, thanks!



____________________
Lyme joints, EMF sensitive, MP start 8/10; 25D <4ng/ml 6/19; vegetarian; olmesartan only-240mg/d, RF shielding required, My Progress: http://tinyurl.com/z2stwo8
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 Posted: Sun Apr 14th, 2013 07:19

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Just finished reading the paper.  Well that sure turns mainstream medical thinking on its head!  :) :) :)

Hope it garners a lot of attention and engenders a ton of discussion and further research by others.  :cool:

Congratulations on putting together such a well-researched and eminently readable paper! :D



____________________
"Life is a whim of several billion cells to be you for a while." Groucho Marx.
MP start May'11 (2 breaks: one in December '15 and one Jan-Mar '18) | Lyme Disease '93, CFS/ME '10 | muscle/joint pain, severe fatigue, myriad neurological symptoms
Paisleykilt
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 Posted: Sun Apr 14th, 2013 07:22

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Are we allowed to forward this paper to others?  I'd like to send it to Dr. Alison Bested who is in charge of a new chronic diseases clinic opening in British Columbia very shortly.



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"Life is a whim of several billion cells to be you for a while." Groucho Marx.
MP start May'11 (2 breaks: one in December '15 and one Jan-Mar '18) | Lyme Disease '93, CFS/ME '10 | muscle/joint pain, severe fatigue, myriad neurological symptoms
Prof Trevor Marshall
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 Posted: Sun Apr 14th, 2013 09:24

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Yes, the preprint can be sent to anybody, that is its big advantage compared to a copy bought from the journal.

I am not sure Alison will be so keen to find out she has a CFS expert (Greg) in her back yard. But I guess she will find out eventually :) By all means send it around.

Also, Inge's presentation transcript is available here:
http://autoimmunityresearch.org/transcripts/Auto2012_IngeLindseth.pdf

..Trevor..

Marysue
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 Posted: Sun Apr 14th, 2013 12:19

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Congrats to all!  Thanks so much for the time and effort you all put in to this paper.
:):):)

Marysue



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MP Apr09 (no breaks)| CFS/FM,infert/endometriosis, Autism Spec | hypotension, cardiac IP, chronic muscle/joint pain, severe light sensitivity, sensory/auditory processing | last 25D=12.5 Sep'11
Bella
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 Posted: Sun Apr 14th, 2013 14:07

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I am so proud and glad for all of us!! Thanks for the hardwork!!! You all deserve a standing ovation and more!!!!!! :dude::dude::dude::dude:

I would like a hardcopy of this journal article. How do I obtain one?

Thanks, Jeannine

Last edited on Sun Apr 14th, 2013 14:12 by Bella



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MP Break (5years) | CFS'92 | Fatigue | 25D=7 Dec. '13
Prof Trevor Marshall
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 Posted: Sun Apr 14th, 2013 14:15

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Check your email, Jeannine :)

Malcolm Jackson
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 Posted: Tue Apr 16th, 2013 04:18

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Firstly congratulations and thanks to all for the hard work in putting this paper together.

Secondly there a typo on page 6?

Cathelicidin possesses antibacterial, antiviral, and
antifungal activity. Human beta-defensin plays a key
role in allowing the immune system to target both
gram-positive and gram-negative bacteria [57]. It also
mitigates viral virulence [57]. Human beta-defensins
HBD-1, HDB-2, and HBD-3 have also been shown to
target the opportunistic yeast species Candida albicans
[58], which has been detected in patients with CFS/ME.
In addition the AMPs play an essential role in the
protection of skin and other organs [59]. They not only
kill microbes but also regulate host physiologic
functions such as in!ammation, angiogenesis, and
wound healing [59].

Should HDB-2 be HBD-2?

Finally. I understand the meaning of peer reviewed but will that convince my Doctor to prescribe Olmesartan? I am one of the many who are self funded in this.



____________________
ME10yr+ chronic sinusitus 25D<10 (May08) paroxetine Mirtazapine, Zolpidem or Zopiclone P1May08 P2June08 D25-10. July08 D25 13.7 April-12.10/12 Oct 14 VitD 15nmol/L
GillyB
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 Posted: Tue Apr 16th, 2013 06:43

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Malcolm, I'm self-funded too, but not because I can't get a prescription.  My &#*%^*$ health insurance won't pay for it at the dosage required, or at all.  For you, the problem is probably the British Health Service.  Your doc is probably leery of getting hammered by the BHS for prescribing off-label.



____________________
MP start Jun'12, once again on an MP break | Degenerative Disc Disease, Osteoarthritis, Post-Lyme, depression/anxiety, GI. Most recent serum 25D: 6/15 -18
Carry on, and keep MP'ing
Malcolm Jackson
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 Posted: Tue Apr 16th, 2013 08:17

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Hi Gilly. You're right. My doctor will prescribe it but has been told not to over prescribe. I have to wait until it's an accepted treatment, till then I have the lottery of whatever turns up from India via Hong Kong paid through a German bank.



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ME10yr+ chronic sinusitus 25D<10 (May08) paroxetine Mirtazapine, Zolpidem or Zopiclone P1May08 P2June08 D25-10. July08 D25 13.7 April-12.10/12 Oct 14 VitD 15nmol/L
uvbogden
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 Posted: Thu Apr 18th, 2013 00:48

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1. For the first time I feel I really understand this, thank you for your excellent work and dedication to find answers for an otherwise "orphaned" group. Could I also get a copy of the journal publication?

2. It is clear, as you say, that conventional medicine only offers immunosuppressive symptomatic treatment which limits the body's ability to eliminate the microbes causing the inflammation in the first place. While immunostimulation may worsen symptoms short-term, positive treatment helps the body eliminate the microbes and actually cure the disease.

2. Could VDR be the only regulator of innate immunity?

3. Why was the article limited to CFS/ME when many other chronic inflammatory diseases share the same symptoms and processes?

4. Many scientists believe that dinosaurs became extinct in response to migrating herds that brought new diseases and microbiomes to existing herds (and vice-versa). When Europeans first came to America, they brought many diseases that had existed for hundreds of years in Europe giving the Europeans a relative immunity, while Native Americans were decimated by these diseases (i.e. smallpox). As there is increased global travel and MacDonald's are springing up around the world, are we taking obesity, diabetes and heart disease to the third world?

5. What about the tendency of Benicar to increase blood levels of potassium, sometimes to dangerous levels? Is this more of a problem when taking more than one 40 mg dose each day as recommended for hypertension? When are we going to get a Benicar generic that's not as expensive?

6. Can probiotics or customized microbial treatment help you acquire a healthier microbiome?



____________________
Sarcoidosis with lung disease, fevers, CFS/Fibromyalgia, neurologic problems, headache, neck and back pain, flushing and sweating, central apnea at night and sleep attacks by day, unable to work.
Prof Trevor Marshall
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 Posted: Thu Apr 18th, 2013 05:15

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uvbogden, I am attending a conference today, will respond this evening.

..Trevor..

paulalbert
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 Posted: Thu Apr 18th, 2013 17:39

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Yes, Malcolm, that is a typo. :(

Oh well.

Paul



____________________
Diag CFS 6.03 / sympt since 9.02 / exercise, food intol, sleep prob / 1,25D: 16, 4.06; 1,25D:27, 25D:26 7.04; 1,25D:43, 25D:6 6.05; 1,25D:17, 25D:8 8.05; / MP: 7.04 / Ph. 3 / Bacteriality
uvbogden
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 Posted: Thu Apr 18th, 2013 19:05

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I had additional questions that I'll add here:

7. I have Sarcoidosis with many of the symptoms of CFS/ME. However, my calcium, ACE, 25-D and 1,25-D levels are all low. Does this mean VDR does not play a significant role in my chronic inflammation? Or do blood levels not always
represent what's going on in the cells?

8. I'm trying to convince my health insurance company to help pay for my immunostimulation. One thing they will refuse to pay for is anything "experimental". Looking on your websites for details (including the use of multiple doses of Benicar per day) to send them I ran across a number of key words that suggest, even though I know this has been a part of medical practice for decades, that the MP might be experimental: "research foundation", "study site", and "cohort".

Do you have or could you create literature that omits these words and clearly states that the MP is no longer "experimental". It might help others as well to get insurance coverage for the MP.

Last edited on Thu Apr 18th, 2013 19:09 by uvbogden



____________________
Sarcoidosis with lung disease, fevers, CFS/Fibromyalgia, neurologic problems, headache, neck and back pain, flushing and sweating, central apnea at night and sleep attacks by day, unable to work.

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