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Vit D does not increase Calcium Absorption
 Moderated by: Prof Trevor Marshall Page:  First Page Previous Page  1  2  3  Next Page Last Page  
 

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wrotek
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 Posted: Mon Jul 27th, 2015 12:13

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I have  absolutely no idea :) it was 20-30 years ago

Still it is amazing doctors see cases like that and they don't think why osteoporosis is not getting better and they do the same over and over again to  treat this condition

Last edited on Mon Jul 27th, 2015 18:08 by wrotek



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hartley
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 Posted: Mon Aug 3rd, 2015 21:26

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I had to revisit this thread to bolster my thinking after reading this today on the BBC website...
http://www.bbc.co.uk/news/health-33757929



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Prof Trevor Marshall
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 Posted: Mon Aug 3rd, 2015 21:45

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Thanks, Hartley, I will use that in my keynote in Toronto - on the hazards of Biomarker design...

Prof Trevor Marshall
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 Posted: Tue Aug 4th, 2015 02:46

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Another paper - Vit-D supplements same value as placebo

"High-dose cholecalciferol therapy increased calcium absorption, but the effect was small and did not translate into beneficial effects on bone mineral density, muscle function, muscle mass, or falls. We found no data to support experts’ recommendations to maintain serum 25(OH)D levels of 30 ng/mL or higher in postmenopausal women. Instead, we found that low- and high-dose cholecalciferol were equivalent to placebo in their effects on bone and muscle outcomes in this cohort of postmenopausal women with 25(OH)D levels less than 30 ng/mL"

http://archinte.jamanetwork.com/article.aspx?articleid=2422066

http://www.reuters.com/article/2015/08/03/us-health-menopause-bones-idUSKCN0Q81TV20150803

Even though they were under 30ng/ml (12 ng/ml) :) NO BENEFIT :)

..Trevor..

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 Posted: Tue Aug 4th, 2015 13:53

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If everyone is deficient in vit D, how come you never hear of anyone who actually has rickets?



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wrotek
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 Posted: Tue Aug 4th, 2015 14:29

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I asked the same question to mine doctor. Rickets only occurs in young developing bones. The disease of developed bones is osteoporosis

p.s. i used to have rickets :) and they gave me vitamin D... I still have some uneven skull, mother used to put mine head on one side one time and the other side the other time, because it was so soft :D like eggshell , she was forming it LOL

Last edited on Tue Aug 4th, 2015 14:31 by wrotek



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madhouse
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 Posted: Fri Aug 7th, 2015 19:22

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I see this thread started several years ago but apparently nothing has changed. I work in the medical profession and Doc's still push vit D like candy. In fact all my chronic inflammatory or "autoimmune" patients are on mega doses of it. Medicare in the US requires us to council fall patients on the importance of vit D supplementation to prevent broken bones. I will not do it!

Vit D is alive and well folks! It's going to take more than a few studies to stop it.



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 Posted: Fri Aug 7th, 2015 19:42

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Well, at least there are a series of studies now showing you are correct. However, the papers all use big words, way beyond the capabilities of Medicare decision-makers :X

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 Posted: Mon Aug 24th, 2015 11:32

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On Australian ABC radio today:
http://mpegmedia.abc.net.au/rn/podcast/2015/08/hrt_20150824_1730.mp3

Here's the web page reference (in case the above podcast audio doesn't work)
http://www.abc.net.au/radionational/programs/healthreport/calcium-vitamin-d-supplements-necessary/6720616


Cheers!
Claudia

Last edited on Mon Aug 24th, 2015 11:53 by Claudia



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mvanwink5
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 Posted: Mon Aug 24th, 2015 12:01

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Thanks, Claudia.
So, researchers are now saying, basically, 'tough luck,' and miss the chronic disease forest for the tree leaves.



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Claudia
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 Posted: Mon Aug 24th, 2015 12:11

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yeah, basically they are saying "we are puzzled" but at least they admit the past studies were wrong AND biased.

We have to hope they go on to ask the obvious questions about WHY they got those results! We live in hope..



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 Posted: Mon Sep 21st, 2015 06:16

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As a relative newcomer I am trying to catch up on protocol-related reading and research linked on the study site and anywhere else I can find it. I noted that the paper reporting a study finding that vitamin D does not improve calcium absorption, referenced in Prof. Marshall’s 10/31/2013 post in this thread is no longer behind a paywall and can be accessed in full by clicking on the same link provided in 2013. http://onlinelibrary.wiley.com/doi/10.1002/jbmr.2121/abstract and then selecting PDF. There is so much new (to me) information – including studies such as this that turn decades of thinking upside down. My sense is that Prof. Marshall has put a puzzle together while much of the scientific community is getting more puzzled by the pieces.

Last edited on Mon Sep 21st, 2015 06:32 by Damselfly



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Claudia
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 Posted: Sat Jan 9th, 2016 01:57

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And another recent study - this one shows that "Vitamin D" supplementation not only does not help, it actually increases falls and fractures.

http://archinte.jamanetwork.com/article.aspx?articleid=2478893



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Claudia
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 Posted: Tue Sep 13th, 2016 05:00

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What do we know about this lot?
http://www.sunarc.org/about.htm



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Joyful
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 Posted: Tue Sep 13th, 2016 05:30

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They are truly in the dark. ;)

http://www.pharmacynews.com.au/news/latest-news/doctors-slam-calcium-and-vitamin-d-conflict-of-int


Same cast of characters. Also, see Benefactors page:
Benefactors Information
SUNARC is incorporated under California law. The federal 501(c)3 form has been submitted, and SUNARC is being operated in accordance with the guidelines for nonprofit public interest corporations.
Disclosure
SUNARC receives funding from Bio-Tech Pharmacal, Inc. (Fayetteville, AR) and the Vitamin D Council (San Luis Obispo, CA).

Last edited on Tue Sep 13th, 2016 05:47 by Joyful



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Claudia
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 Posted: Tue Sep 13th, 2016 06:36

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Hi Joyful, thanks. I went ahead and looked them up myself and found all their conflicts of interest, plus one of their listed benefactors doesn't seem to exist.
(Someone had quoted them to me in a FB post, and I wanted to refute their stuff.)



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 Posted: Tue Sep 13th, 2016 18:07

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As the body of quality research grows,
the "More is better!" club keeps losing members ...
U-shaped relationship between vitamin D levels and long-term outcome in large cohort of survivors of acute myocardial infarction.



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Claudia
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 Posted: Thu Sep 15th, 2016 13:33

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A friend of mine recently told me that redheads make more vitamin D than other folks. Apart from the pale skin allowing more sun in, they are saying that the actual genetic mutation responsible for red hair (mutated MC1R gene) also causes increased production of vitamin D.
Is there any substance to this belief?
Thanks for the input!
Claudia (definitely a "carrier" of this gene, having spawned a redhead!)



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Prof Trevor Marshall
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 Posted: Sat Sep 17th, 2016 19:35

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Very little (only a few percent) of the Vit-D in the blood is generated in the skin. Each cell produces the Vit-D it needs -- without any sunlight.

Direct sunlight causes the skin to start a damage response, and the (healthy) body then generates more Vit-D internally. But nobody has been able to measure an generation of Vit-D in the skin itself - of either mice or men. This is an old-wives' tale.

I would suspect the redhead gene thing is also lacking in science.

..Trevor..

Claudia
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 Posted: Mon Sep 19th, 2016 08:47

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OK, I understand about those things, but what do you know about the mutated MC1R gene that was mentioned? I didn't know anything about it, mutated or otherwise, until a friend brought the subject up. I've had a look online and found several interesting articles suggesting there is certainly something - or several things - going on with redheads apart from hair colour. This includes their being twice as likely to have Parkinson's and a link to inflammatory response. Here is one quote:
"The melanocortin 1 receptor is also active in cells other than melanocytes, including cells involved in the body's immune and inflammatory responses. The receptor's function in these cells is unknown."

- https://ghr.nlm.nih.gov/gene/MC1R


This article seems to touch on both the VDR and MC1R, but I don't understand the science.
http://www.neurology.org/content/62/12/2323.short

This article, although not scholarly, was interesting:
http://www.medicaldaily.com/8-ways-having-red-hair-affects-persons-health-pain-sex-348198

Last edited on Mon Sep 19th, 2016 08:48 by Claudia



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