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Our Presentation at the FDA CDER is now online
 Moderated by: Prof Trevor Marshall Page:    1  2  3  4  Next Page Last Page  
 

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Prof Trevor Marshall
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 Posted: Wed Mar 15th, 2006 08:00

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The video of our presentation has been catalogued in the FDA Biosciences library, and your library can even request it on InterLibrary Loan (I think).
I guess that if you want to cite the presentation in a paper you would use something like:
"Marshall TG: Molecular genomics offers new insight into the exact mechanism of action of common drugs - ARBs, Statins, and Corticosteroids. FDA CDER Visiting Professor presentation, FDA Biosciences Library, Accession QH447.M27 2006"

An online 'RealVideo 9' version of the DVD of my FDA CDER presentation is available online at url
http://autoimmunityresearch.org/fda-visiting-professor-7mar06.ram

The running time is 1 hour, including question-time. I suggest you set your viewer to "Double Size" or "200%" so that the image is a little larger.

A copy of the slides, in Adobe Acrobat PDF format, is at URL
http://autoimmunityresearch.org/fda_visiting-professor_7mar06_144dpi.pdf

The original DVD of the presentation can be requested from
http://autoimmunityresearch.org/fdacder.htm

..Trevor..

ps: The presentation is 50 megabytes in size, and it can be downloaded in total by right-clicking on this link
http://tinyurl.com/n8bvf
(Thanks to John McDonald)

Last edited on Sun Mar 19th, 2006 00:30 by Prof Trevor Marshall

Frans
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 Posted: Wed Mar 15th, 2006 08:02

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dr Marshall, I can't download by right clicking, is it supposed to be that way?

sincerely, Frans



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Prof Trevor Marshall
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 Posted: Wed Mar 15th, 2006 08:06

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Frans,
If you need to download the presentation to your disk, for example if your Internet connnection is too slow to stream online, then please right-click on this URL:
http://autoimmunityresearch.org/fda-visiting-professor-7mar06.rm

It is a 50 megabyte file.

paulalbert
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 Posted: Wed Mar 15th, 2006 08:43

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Why don't you upload the complete original to Google Video? YouTube also has free hosting. Their servers are pretty snappy. If you need help converting the file to an appropriate format, I would be happy to help.

Paul



____________________
Diag CFS 6.03 / sympt since 9.02 / exercise, food intol, sleep prob / 1,25D: 16, 4.06; 1,25D:27, 25D:26 7.04; 1,25D:43, 25D:6 6.05; 1,25D:17, 25D:8 8.05; / MP: 7.04 / Ph. 3 / Bacteriality
Prof Trevor Marshall
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 Posted: Wed Mar 15th, 2006 08:59

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Paul,
The DVD itself is 1.6 gig big. I was thinking of setting up a torrent for those who can master that technology, but haven't had any experience with Google Video. Like I said, if you can offload the work from me I would would be happy to help:) I am using the Vegas 6.0 editor, and can export the presentation in a variety of formats.

Note that I have just received the FDA Biosciences Library accession number, and have put that up in my starting message (above)

Frans
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 Posted: Wed Mar 15th, 2006 09:23

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Oh man, I am only at minute 20 and already I am totally blown away

dr Marshall, you are totally incredible

one question, the Methicillin Resistant Staph Aureus you mention in the beginning of your presentation, is that the elusive MRSA bacteria hospitals are so afraid about?

Am I right if I understand they are susceptible to ARB's?

Sincerely, Frans



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Jvancan
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 Posted: Wed Mar 15th, 2006 09:26

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Thank you, Dr. Marshall for the great work and effort!

It would be nice if you could set up a torrent for the whole 1.6Gig version.

Thanks again,

Jeroen

Prof Trevor Marshall
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 Posted: Wed Mar 15th, 2006 09:33

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Frans:
Yes, MRSA252 is one of the "superbug" species.

My modelling shows the MRSA252 genome will respond to the presence of ARBs, just like the other bacterial species behind Th1 disease.


Jeroen:
I have set up a torrent for the ISO of the DVD at URI
magnet:?xt=urn:btih:FADD7OKE5TODIOR7NAQSBQDP7FQIVNFR

Those of you who are torrent-savvy should be able to access the torrent now (copy and paste the magnet to your browser URL window)(I can see that Jeroen is now downloading it OK) - and remember - please keep seeding the torrent to help overall bandwidth...

Last edited on Wed Mar 15th, 2006 10:39 by Prof Trevor Marshall

paulalbert
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 Posted: Wed Mar 15th, 2006 10:39

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Trevor,
If I'm not mistaken, 1.6 gigabytes is much bigger than it has to be for the purposes for a non-DVD file. I've been working on converting my family's home movies and based on what I've seen doing that, you could reduce the file size by a factor of 10.

That point aside, I think you might be better served to upload the file to Google Video, given the prospect of wider publicity and the trouble with downloading a torrent-based file after initial interest wanes a bit. Here are the format specifications for Google Video:

Google accepts video in a wide range of popular formats. The fastest way to get your videos into Google Video is to submit each file in MPEG4 format with MP3 audio or MPEG2 with MP3.

While we also support other digital formats such as QuickTime, Windows Media, and RealVideo, it's important to note that submitting your files in these formats may significantly delay us from using them on Google Video. In some cases, we may not be able to add your video at all.

Here are our preferred video specs:
NTSC (4:3) size and framerate, deinterlaced
Video Codec: MPEG2 or MPEG4 (MPEG4 preferred)
Video Bitrate: at least 260Kbps (750kbps preferred)
Audio Codec: MP3 vbr
Audio Bitrate: at least 70Kbps (128 Kbps preferred)


Vegas Video 6 can output MPEG-2 files. I didn't see if MPEG-4, a better conversion standard, was available. So, if you're game, I would say:
1. Output the file in MPEG-2.
2. Go here.
3. Set up an account.
4. Upload the file.

For that matter, I think it would be kind of nice to have all of your media at Google Video, unless of course you want some recompense for your cinematographic efforts. :)

Paul

p.s. If you are too busy or whatever, I would be happy to do this, once a torrent file exists.



____________________
Diag CFS 6.03 / sympt since 9.02 / exercise, food intol, sleep prob / 1,25D: 16, 4.06; 1,25D:27, 25D:26 7.04; 1,25D:43, 25D:6 6.05; 1,25D:17, 25D:8 8.05; / MP: 7.04 / Ph. 3 / Bacteriality
Prof Trevor Marshall
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 Posted: Wed Mar 15th, 2006 10:52

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Paul,
The DVD datarate is already low - 3500 KBps - so a 1.7 gig ISO is about the most compact you are going to get TV quality, I am afraid. The RealVideo 9 datarate is 100KBps, and this compression format is (arguably) better than MPEG4.

The problem I have with using Google Video is that the uploads are public forever. You know, I am not really proud of some of the mistakes I made when I gave the Westlake Lyme presentation 2 years ago, and I would be embarrassed if folks stumbled across that video on the Internet and assumed it was my current thinking. It is good to be able to retire videos when you have updated material to present. Google doesn't allow that.

Anyway - the torrent seems to be working OK, so that will enable International folks to quickly get their copy of the full-quality presentation. Within the USA we can mail out the DVDs. Actually, I think the streaming online RealVideo stream is quite good enough, especially if you have a color printout of the slides in your hand :)

Frans
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 Posted: Wed Mar 15th, 2006 11:47

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Trevor,

I remember you saying at a certain day that normal/clinical and molecular medicin are still way to far apart.

If I am not mistaken, you have just bridged that gap.

This is revolutionary stuff I think, do you think that came across to your audience? Did they really fathom what you were telling them?

I also want to say that it keeps surprising me how you seem to get the most difficult information across in a way that even a lay-man like me understands exactly what you are saying.

Absolutely fantastic work!

Most sincerely, Frans

Last edited on Wed Mar 15th, 2006 11:51 by Frans



____________________
Burn-out/nervous breakdown Jan01 125D 48 25D8.48 Ph1Nov06 ModPh2Jan07 Ph2Apr08 Cipramil Seroquel NoIRs lite exp r/t work cover up 25D3.9(Oct07)
Prof Trevor Marshall
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 Posted: Wed Mar 15th, 2006 11:51

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To all:
Here is the .torrent file you should be able to just click on, and then your bittorrent program will spring into action (if you have one):
http://autoimmunityresearch.org/fda_presentation.iso.torrent
(thanks to Jeroen for finding that file)

Frans:
I think that the FDA folk didn't really understand the full implications of what I was saying. But now that a copy of the DVD is in their library there is a tangible record they can refer to whenever the opportunity (or need) arises.

Trevor

Jvancan
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 Posted: Wed Mar 15th, 2006 12:00

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And I would like to add, for the people who don't have a Torrent Downloading Client yet, here is a good one:
http://azureus.sourceforge.net/download.php

Jeroen

wrotek
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 Posted: Wed Mar 15th, 2006 13:17

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I am during watching-marvellous,the effects of wide spectrum of different ARBs actions showed on the table are amazing.

I am just curiuos, How 1,25-D is decreased if VDR is blocked ? I mean if angiotensin II type 1 receptor is blocked then body puts out more angiotensin II am i right ? But with 1,25-D it is opposite.


sorry but the torrent file dosen`t seem to be working with my bitcomet client, the error occurs "error tracker data-wrong data string "

Last edited on Wed Mar 15th, 2006 14:48 by wrotek



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paulalbert
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 Posted: Wed Mar 15th, 2006 16:07

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Trevor said:The problem I have with using Google Video is that the uploads are public forever.

This is not so. Here's a snip from Google Video's FAQs:
Can I remove my videos after I upload them?

Yes. You can use the delete feature on the Video Status page to remove videos that you have uploaded to us. If the video is not yet live, it will be deleted immediately and permanently from your account. If your video is live, it will be removed from your account and the Google Video index as soon as is possible.

No matter though. Do as you wish.

Paul



____________________
Diag CFS 6.03 / sympt since 9.02 / exercise, food intol, sleep prob / 1,25D: 16, 4.06; 1,25D:27, 25D:26 7.04; 1,25D:43, 25D:6 6.05; 1,25D:17, 25D:8 8.05; / MP: 7.04 / Ph. 3 / Bacteriality
Prof Trevor Marshall
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 Posted: Wed Mar 15th, 2006 17:12

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Paul,
Excellent Info. Thank you. I will put a copy on Google later this evening (busy right now).

Wrotek, there are 5 peers connected to the Bittorrent swarm right now, with an average completion of 32%. So you should be able to connect to one of them:X I do note that the two connected to me right now are using Azureus, not Bitcomet, but that shouldn't matter.

Prof Trevor Marshall
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 Posted: Wed Mar 15th, 2006 17:18

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I was asked what the DVD of the presentation looks like.

It is in a case, slimline, 9mm thick, with a cover insert saying what the DVD is, and the DVD itself is printed with the ARF logo and a description of what is the DVD - namely just my FDA lecture, which runs for 1 hour 1 minute, including questions.

We are using a PayPal system for the First Class postage, as we get a delivery notification (we can make sure it is delivered).

The DVD of the presentation can be requested from
http://autoimmunityresearch.org/fdacder.htm

Jvancan
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 Posted: Wed Mar 15th, 2006 23:11

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Wrotek,

It works in Azureus, but I think the tracker has some problems in your client. You can also use the magnet link:
magnet:?xt=urn:btih:FADD7OKE5TODIOR7NAQSBQDP7FQIVNFR


Jeroen

wrotek
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 Posted: Thu Mar 16th, 2006 00:40

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It works very well indeed, the azureus client runs magnet while bitcomet does not



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Dogster
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 Posted: Thu Mar 16th, 2006 06:08

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Can anyone address Wrotek's questions in Mar 15 post, second paragraph??

Dogster



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