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Our Presentation at the FDA CDER is now online
 Moderated by: Prof Trevor Marshall Page:  First Page Previous Page  1  2  3  4  Next Page Last Page  
 

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Prof Trevor Marshall
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 Posted: Thu Mar 16th, 2006 06:13

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Dogster,
The interaction between the expression of 1,25-D, IL2, Interferon-gamma and VDR is too complex to quantify at this point. The only thing certain is that VDR is hyper-activated by the pathogens behind Th1 disease. Reducing VDR hyper-activity is clearly necessary to restore proper functioning of the immune system.

ericmarshal
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 Posted: Thu Mar 16th, 2006 06:48

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Hi,
While not sure this is the proper thread, there may be a linkage.  What possibilities does this "New" immune cell discovery add to the MP?  mm
 
 
Newly Recognized Immune Cell Unveiled in Asthma
MedPage Today - Little Falls,NJ,USA
... In a study of pulmonary specimens from 25 adults, 14 had moderate to severe persistent bronchial asthma, six were healthy participants, and five had sarcoidosis ...



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Prof Trevor Marshall
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 Posted: Thu Mar 16th, 2006 07:02

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Not relevant, Eric. They were not looking for intracellular pathogens. Therefore they are not confounding out errors due to differing severities of disease condition. Even if they stumbled across the answer they wouldn't have recognized it as an answer.

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 Posted: Fri Mar 17th, 2006 01:12

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Dr. Marshall,

Congratulations! Your FDA Presentation was Brilliant!!!:D Although most of the technical information was over my head I did gain some very valuable information!:D

What fascinated me the most was your finding that the immune system is interwined with lipid metabolism......and that the cholesterol and lipid metabolism both trace back to the VDR and PPAR:D and that the PPAR affects the generation of lipids.

That was a wonderful suggestion you made to the FDA regarding a data base library for students and scientists regarding drug side effects and comparing the ARB's to the ACE drugs, etc.

The comparison charts were incredible showing the effects of the different drugs and how they affect the organs, thyroid, etc. But that the ARB's do not cause the side effects that the ACE drugs do.

It gave me a much better understanding of the role of the ARB's:cool:

And lastly, the fact that the olmesartan goes into the cells reducing the 125D hormone.

Again, you were brilliant and I feel very priviledged to be a part of the Marshall Protocol!:cool:

Sincerely,

DianeC



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Lantern
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 Posted: Fri Mar 17th, 2006 17:14

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I can't seem to download the torrent. I use utorrent, which I don't think uses magnets (anyone?), but I saved the .torrent file and it is coming up as usual in the list. However, it says the tracker is sending invalid data.. I can see one other peer, but no seeders. Any help?



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wytnez
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 Posted: Fri Mar 17th, 2006 17:34

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I just watched the FDA presentation again and it is so amazing to see how the drugs (ARBs and Statins) affect different cell and molecules. I think that is a great idea to have data base of all the drugs and the affects and side affects they may have.

Saj

Last edited on Fri Mar 17th, 2006 18:06 by Prof Trevor Marshall



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Prof Trevor Marshall
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 Posted: Fri Mar 17th, 2006 17:56

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Shadowzone,
I wish I knew more about magnets and torrents, but I don't. I can see two peers on the torrent at the moment, but they are not located in Australia. There are four seeds right now. Have you thought of leaving your question about 'magnets' on a utorrent message board? Maybe somebody could help you there?

Saj,
I edited a line out of your message. The answer is "yes," but I want to minimize embarrassment all around:)

Prof Trevor Marshall
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 Posted: Fri Mar 17th, 2006 22:20

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HEY FOLKS, those of you with full copies of the DVD - please leave your Bittorrent on as SEEDS. I currently can see Shadowzone (I presume) from Australia and a download from Germany, as well. At this point I have uploaded nearly 5 complete copies myself - the aim of Bittorrent is to share the load:):)

Jvancan
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 Posted: Fri Mar 17th, 2006 22:32

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Yes that's true. I leave mine on as a seed and Frans also does. There are a few client who seem to have problems with our tracker i guess. So when you want to be sure it works... use Azureus. And when it does not work with Azureus it's probably your firewall what is causing the problems.

DianeC
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 Posted: Fri Mar 17th, 2006 22:44

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After I viewed the presentation last night a message came on stating that if I wanted to view it again or anything else I would have to download REAL PLAYER  Is is safe to do that??  I usually hesitate downloading anything unless I am positively sure it is safe:?  Any comments?

thanks a bunch:cool:

DianeC 



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Jvancan
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 Posted: Fri Mar 17th, 2006 23:05

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Diane,

I would advice if you have a Windows computer to use:
http://www.free-codecs.com/download/Real_Alternative.htm

Some advantages compared to RealPlayer :

- Quick and easy install
- It's easy to make an unattended installation
- Proper uninstallation
- No background processes
- Use a player of your own choice
- Low on resources
- No advertising, no registration forms, nothing annoying


Jeroen

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 Posted: Fri Mar 17th, 2006 23:31

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Thank you Jeroen for your computer expertise!:D  That sounds great!!  It is much appreciated!!:D

DianeC



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Frans
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 Posted: Sat Mar 18th, 2006 05:10

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dr Marshall,

If I understand correctly, you have a paper finished and applied and in that paper you theoretically prove that ARBs inhibit the function of an MRSA bacteria.

Isn't this worldschocking news? Wouldn't it be a thought to explicitly name MRSA is the title of the new paper? Maybe I am not understanding the implications correctly, but this seems a discovery unmatched in its significance.

Am I missing something?

Sincerely, Frans



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Frans
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 Posted: Sat Mar 18th, 2006 06:42

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dr Marshall,

I have another question. In the slides you show on the presentation, lower numbers indicate higher affinity fir the receptors.

Is that because that signifies that even at very low doses, the molecules already bind to these receptors?

TIA

Sincerely, Frans



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 Posted: Sat Mar 18th, 2006 07:03

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I thought that ARB antibacterial properties were shown firstly with psychodelic dreams of sarcoidosis patients, but it seems that scientists knew already bacterial affinity to ARB`s while they were testing drugs in 1990`s, but they did not know what it meant . :dude: . DId they wrote papers about this interactions ? ARB are bacteriostatic or bacteriocidal ? I suppose bacteriostatic cause they put bacteriocidals to kill microbes to tissue so the ARB could bind to tissue.

BTW are there any interesting books about molecular modelling? few months ago i was reading about basics in some science magazine in Poland and saw the same molecule showed by Dr Marshall in Chicago- it was one of antibodies T-shaped :) I guess they are out of date with science :D:D;)

Last edited on Sat Mar 18th, 2006 07:26 by wrotek



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Prof Trevor Marshall
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 Posted: Sat Mar 18th, 2006 10:13

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Wrotek,
I cited the early papers which noted bacteria had an affinity for ARBs in our paper a couple of years ago "Putative antibacterial actions of ARBs." At that time I had no idea of the mechanism of action, and was still focused on Angiotensin II, but you will find the historical review data there.

Frans,
I scheduled two meetings at the NIH while I was in Washington. One went well, but the other, with a senior member of NIH's research staff started off by my being told that my molecular modelling was "worthless." So we didn't get anywhere productive in that meeting. Even though he has 212 published papers, he has apparently been very slow to understand and embrace new technologies, especially genomic technologies. TPTB seem unable to see the forest for the trees.

I am also having difficulty getting the Infectious Diseases people to understand the importance of what we have discovered about the profound actions of Benicar on the pathogenic genomes. It hasn't even entered their minds that such a thing might be possible.

For example - I submitted an abstract to the ISID conference asking for an oral presentation, and I got back an acceptance, but only for a poster presentation. I am therefore inclined to not bother with that group, withdraw the offer of presentation, and look for other conferences where I can get the word out more effectively (these big conferences are very expensive to attend, even though you get a large group of researchers to talk with). You and I might understand the importance of our work, but the technology still appears to be too much like magic to TPTB, apparently.

wrotek
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 Posted: Sat Mar 18th, 2006 10:56

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"worthless" is a very strong word, i wonder were there any reasons(arguments) why it was used or just emotions. If everybody would understand then there would be nothing to do :)

Last edited on Sat Mar 18th, 2006 11:06 by wrotek



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Prof Trevor Marshall
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 Posted: Sat Mar 18th, 2006 11:06

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It may have been professional jealousy, a fear of new technology, or maybe just a bad experience in the past with a research project which didn't work out. I don't know. But "worthless" was the exact word. In his second or third sentence. Followed a few paragraphs later by the question "Well, which bacterial species is it which causes Sarcoidosis, then?" followed by an unwillingness to even contemplate horizontal DNA transfer. He wanted the name of a simple, singular species. Sigh... I can understand that coming from a typical pulmonologist, but look at the subject-matter of the papers this fellow has gotten author credits for:X That stuff is complex:X

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 Posted: Sat Mar 18th, 2006 11:18

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WHen i read terrible stories of sick people, sarc, Lyme , other, i just can`t imagine doctor using that kind of word in this background. That is why i think clinicians are the best open minded doctors to show them new options of treatment like MP, because they see suffering patients where theoretical "on paper" Scientists do not.



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 Posted: Sat Mar 18th, 2006 12:10

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dr Marshall,

Is there any way we of the cohort can put pressure on anyone by getting this message out?

It seems to me that if your next paper is published, theoretically proving that MRSA is weakened by ARB's, making them an interesting antimicrobial, or at least a medicin that could enhance the actions of abx against these dreaded bacteria, we should all be writing scientific editors in our own countries, making them aware of your findings.

We can make a sort of simplified explanation, stating what you have found, and give them links to the abstract on pubmed and possibly to the full-text, if the ARF has enough money to make that happen.

I would be happy to make a simplified explanation in Donald Duck-alike language.

At school I learned about H2O, molecules, affinity between them making news molecules etc at the age of 13 !!!, so I estimate that anyone who has finished highschool should understand the simple basics of what you have done, if explained in layman's terms.

Maybe, if I concoct a simple explanation, you can send that to the person who called this work worthless... He must have been talking about how he views his own Hippocratic oath...

Sincerely, Frans



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