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What I learnt from talking with Rolf Zinkernagel
 Moderated by: Prof Trevor Marshall Page:  First Page Previous Page  1  2  3  4   
 

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Phil Schoner
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 Posted: Sun Jan 7th, 2007 08:42

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Here is a thought regarding why the innate immune system of Dr. Z's mice never attacked the virus in the brain after the few weeks it took to develop (Trevor's $64,000 question). 

The virus was there before the IIS developed, and the IIS said to itself, "Hey, this thing is supposed to be here, I'll leave it alone".  And the virus said, "Hey, IIS, I belong here, and I won't bother you.  I'll just sit here in the corner of the castle.  You go ahead and develop yourself to fight foreign invaders.  We both know that I'm not foreign, I predated you."  So the virus and the IIS lived happily ever after, until the virus received reinforcements in that second challenge.

Phil



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Phil Schoner, MP Support Spouse, no symptoms, 1,25D 74 5/08, 25D 16 12/08, 25D 16 7/09, 25D 15 2/10, ph1 11/08, ph2 12/08, ph3 7/09, started discontinuance of Benicar 12/28/11. NoIR's, sunscreen Went off MP 1/11/2012
Frans
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 Posted: Thu Feb 1st, 2007 08:19

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Trevor,

I have been reading this paper again and again and am starting to get it, I hope.

One question comes to mind though.

From the way dr Zinkernagel presents his theory, I get the impression that what we call autoimmunity is just a theory.

Have there ever been foud antibodies to self? Or is autoimmunity as we knew it just a hypothesis ?

Sincerely, Frans



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Prof Trevor Marshall
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 Posted: Thu Feb 1st, 2007 09:50

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Antibodies are non-specific, as to their target. I am not aware of any definite 'antibodies to self'. In any case, if there was such a thing, the organism would quickly degenerate to a pile of blubber.

Frans
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 Posted: Fri Feb 2nd, 2007 09:37

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Thanks Trevor, that's clear.

dr Zinkernagel probably cracked another problem of autoimmunity, delivering a proven alternative.

What I was wondering about:  I have heard some talk about HERV's maybe being part of the problem, or at least delivering more dna to the pea soup.

But if we consider that stem cells probably are infected, what remains of herv's? Are they indeed in our DNA, or do they get there in this first extremely vulnerable period of life?

Sincerey, Frans

Last edited on Fri Feb 2nd, 2007 10:09 by Frans



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Frans
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 Posted: Fri Feb 2nd, 2007 10:08

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Trevor, a much more important question on my mind is:

how is Interferon upregulated/activated?

I am looking at the following, the pathway of the TLR's:

- http://tinyurl.com/2kmsy7

It looks to me like the TLR's also have a direct link to the IFN's? And perhaps thereby: viruses also, as well as bacteria?

Sincerely, Frans



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Burn-out/nervous breakdown Jan01 125D 48 25D8.48 Ph1Nov06 ModPh2Jan07 Ph2Apr08 Cipramil Seroquel NoIRs lite exp r/t work cover up 25D3.9(Oct07)
Prof Trevor Marshall
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 Posted: Fri Feb 2nd, 2007 20:41

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Sorry, Frans, I am occupied sorting through some new stuff right now. Remind of this in a week or two's time, please.

Frans
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 Posted: Sat Feb 3rd, 2007 05:53

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Thanks Trevor, I'll try to remember, but am on the 2nd abx now... :D:D:D



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eClaire
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 Posted: Fri Mar 16th, 2007 05:37

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Vaccinations were mentioned frequently on this thread and so I've decided to post the following here.

I found the video on this site to be most interesting (note also at the 53 min mark, diseases linked to particular vaccines), although there are things said, particularly near the end that would be contrary to the MP: http://heartspring.net/flu_shot_side_effects.html  

Also at this link you can find (directly under the video) an interesting article written by Dr. Alan Cantwell, Jr., entitled Are Vaccines Causing More Disease Than They are Curing?

While the MP may be the only real cure for many of us with Th1 illness, perhaps vaccinations may be one the leading causes of the infections that cause our illnesses. 

Claire

Last edited on Fri Mar 16th, 2007 06:18 by eClaire



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tibet
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 Posted: Fri Mar 16th, 2007 15:36

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Breast feeding may make some difference to the development of TH 1 disease but i found the speed of development in my 3 children had much more to do with sunlight exposure than any other thing. The son who developed the condition last was a computer junkie and rarely left his room for years. His outdoor loving sister and brother developed the disease 6 years before him....His sister was breastfed for a year......the longest BF child.

stella



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20 years CFS/ME Looking for helpful doctor in UK Have 3 grownup children with disease.

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