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Host Defences - UCSD 2006
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Prof Trevor Marshall
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 Posted: Fri Oct 13th, 2006 17:10

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Greg,
I won't be doing any 'harassing' until I get the 2006 DVDs shipped, and that will be a few days yet:) No time to read anything till then:X

tickbite
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 Posted: Mon Oct 16th, 2006 11:17

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Here is an abstract associating E. coli nissle probiotics with an increase in IL-10 anti-inflammatory cytokines.

Lactobacilli, bifidobacteria and E. coli nissle induce pro- and anti-inflammatory cytokines in peripheral blood mononuclear cells.

I've spent a while reading over abstracts involving IL-10. I really find the work confusing. In some viral models, IL-10 blockade helps rid the infection (Robert's post). In other models it gets too complicated. Some people inject IL-10 genes into models to reduce inflammation.....Personally, I think a lot of this research is just mad scientist style jabbing in the wind. However, it's all still note worthy. I think there's too much "autoimmune" belief, etc running around for there to be any clear cut truth to shine through yet. Unless I haven't found it. Fun to look at though.

This next abstract I find very interesting (besides the researchers unaware of CWD) in the way of them describing borrelia eliciting suppressors of cytokine signaling proteins. Part of an IL-10 mediated inhibition of inflammatory cytokines....strange.

Interleukin-10 anti-inflammatory response to Borrelia burgdorferi, the agent of Lyme disease: a possible role for suppressors of cytokine signaling 1 and 3.


Forgive me if this is an unthoughtfull post. I just like discussion on these scientific subjects...
~Greg



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Frans
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 Posted: Thu Oct 26th, 2006 08:31

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Trevor,

I want to get back to the Letter to the Editor you got published in The Lancet.

I am planning to get this message out to the general public via as many channels as I can reach, ie newspapers, serious medical scientific tv-programs, etc.

The proble is that at this point my energy is lacking to write a piece that covers all the basics, but sitll gets a powerfulk message across.

The Lancet has almost been proclaimed holy, so I think we should get the most out of this.

Maybe someone can give some pointers as to how to approach this subject, to get me started on this. The subject being the fact that vitamin D is immunosuppressive, acts a lot like prednisolon etc.

Trevor, have you perhaps got a .jpg that shows the likeness between the two as you showed at your presentation at FDA CDER ? I know that I for one was blown away when you showed how much the two molecules look alike.

One picture says more than a thousand words, we say over here.

Shall we milk this opportunity dry? :D:D

Sincerely, Frans



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kenc
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 Posted: Sun Oct 29th, 2006 10:52

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The video on Crohn's disease suggests to me that a genetic defect leads to an underproduction of defensins.

1) Does this genetic mutation always lead to an underproduction of defensins or are there other mitigating factors?

2) What role, if any, do cell wall deficient bacteria have in the production of defensins?



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Frans
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 Posted: Sat Nov 11th, 2006 09:48

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Hi all,

I have been working on a document I want to send to newspapers, tv etc. I think we should make the most of the fact that Trevor has been published in The Lancet with the fact that vitamin D is not as fantastic as a lot of people think or want some experts want you to think and is really posing a threat to the general public's health.

I will post the translated text here and I am open for suggestions for better or worse  :?   I am also open for translational errors, so don't spare me :D


Dear Madam, Sir,


Hereby I want to draw your attention to a piece in The Lancet of (date, or number of article) from Trevor. G. Marshall phD.

In this piece, Marshall explains at a molecular level that Viatmin D SHUTS DOWN / DISABLES the Vitamin D receptor (VDR). It is an ANTAgonist of the VDR.

(Vitamin D: D3, 25ohD3, ergocalciferol)

Recent research has shown that the VDR is responsible for the transcription of eg TLR2 and TLR4. (PMID ?????? Anyone know this/these??)

These receptors are at the heart of Innate Immunity. If the transcription of these receptors is hindered (???), our innate immunity DOES NOT WORK !!

Vitamin D is therefore immunosuppressive !!  Just like prednisone…  I have included a picture where dr Marshall shows the molecules of prednisone and Vitamin D next to each other. The similarities are obvious…. (I want to enclose a still from the presentation at FDA CDER which shows D and Prednison next to one another)

Vitamin D has also been proven not to be a vitamin, but is, in actuality, a steroid ! Another similarity to prednisone…

So why is dr Marshall's discovery so important ?

Newborn children, whose adaptive immunity has not yet kicked in !, are totally dependant on a correct functioning innate immune system.

BUT WE ARE KNOCKING THIS OUT WITH VITAMIN D !!!!!!!

How come ??

Vitamin D is being supplemented in baby formula, in our daily foods, etc. Furhtermore doctors are telling young parents to supplement their children with vitamin D in the wrongful understanding that vitamin D is 'good' for you…

dr Marshall has found that levels of 20NG/ML seriously impair innate immunity. These levels are however now called deficient !!   A terrible mistake!

Research has shown that only 1,25 Dihydroxyvitamin D (=1,25D), a successor of 25D, turns the VDR ON. This has to do with a necessary hydroxyl-group that is only present on the 1,25D molecule.

All the other forms of vitamin D lack this necessary component, therefore lacking the ability to turn the VDR ON !!  (here should be a link to KAROLINSKA)

This hydroxyl Group is added to1,25D in the mitochondria of macrophages, as wel as in the kidneys, under influence of 1 alpha Hydroxylase (1a-OHase). This is regulated strictly. Too high 1,25D leads to calcium being resorbed into the bloodstream from the bones, leading to calcium being deposited in soft tissues.

Vitamin D (25OHD) s being measured in NANOgrams. HOWEVER: 1,25D is being measured in PICO-grams !!

So there is a factor 1.000 difference between 25OHD and 1,25D !!  This makes it clear that the most part of the 25OHD we ingest, or acquire via light on our skin, floats around our bloodstream for an indefinite time, before it is picked up by DBP (Vitamin D binding protein) to be stored in our bodyfat.

This free-floating 25OHD is present in such abundance that the molecules 25OHD will bind the VDR at the cost of the molecules 1,25D leading to a serious suppression of our innate immune system !!!!

Sincerely, ….

This is a first draft.



TIA, Frans



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Prof Trevor Marshall
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 Posted: Sat Nov 11th, 2006 11:14

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Ken,
Beta Defensins are transcribed by the VDR. Folk with a dysfunctional Vitamin D system can't produce them.

Although the author talks about a genetic defect, he points out it is not the cause of the disease, as only a minority of patients have it. I told the speaker about Vit D being immunosuppressive, and hopefully he will start looking in that direction now, instead of being distracted by mutations.

Brad
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 Posted: Sat Nov 11th, 2006 11:57

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Frans,

At the risk of sounding stupid, I have never understood what each type of immune system is. Innate and Adaptive ? Also are you saying that 1,25D is the only thing that kicks in innate immunity, I thought too much 1,25D suppressed innate immunity. I thought benicar brought down 1,25D. The more I read the more confused I get. I wish there was a really simple chart or something to help us poor laymen understand .

Thanks,

Paulette



____________________
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tickbite
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 Posted: Sat Nov 11th, 2006 12:50

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Brad/Paulette,

A Brief Overview of Innate and Adaptive Immunity in Relation to the Marshall Protocol

Innate and Acquired Immunity

Unfortunately, coming across a simple layman's chart of everything at the moment might be a bit difficult. This chart shows what 1,25D affects:  Hormonal Diagram

Yes, 1,25D is the only thing which turns on the VDR. The problem is Th1 inflammatory disease patients have way too much of it. We only need a small amount. Excess 1,25D begins to affect other systems in very bad way indeed (that's why we're here):

Hypervitaminosis-D

Supplemented vitamin D (25D) begins to shut down innate immunity. I believe it is also wise to completely restrict natural sources of vitamin D also while recovering from Th1 disease.


Frans,

Good work. You did a good job. If you need help gathering other finer points of things I would be more than happy to help. Otherwise, continue on! perhaps showing a more finalized version would be another good idea.

~Greg



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jrfoutin
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 Posted: Sat Nov 11th, 2006 14:56

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Frans,
I sent you a PM that may be of use. Also, the LAX Conference DVDs contain an excellent set of details.

KAROLINISKA
Do be sure to print out (on good paper at better resolutions) Dr Marshall's Karolinska poster, which is really a fantastic piece of efficient evidence, with charts and graphics that get to the point in a big hurry.

FDA/CDER & AAEM
Dr Marshall's Spring 2006 FDA CDER visiting professor presentation and the Fall 2006 AAEM continuing ed presentation for doctors, he describes exactly why Molecular Genomics is so important, and then goes on to show exactly what has been discovered. Those of us on the MP have catapulted beyond today's research processes into the future of medicine.

VON ESCHENBACH/NORD
Confirming that concept, the NORD presentation on Sept 29, 2006 "Does the FDA Critical Path Tie into the NIH Road Map?," Dr von Eschenbach, acting director of the FDA, used the term "typhoon of change" to describe how Molecular Genomics will exponentially change medicine as we know it today. Belinda quickly approache him after his presentation and asked him directly if he realized how true what he had said was, and he confirmed --with tone-- that he knew exactly what he was talking about! (You have to hand it to Belinda, she made it in front of a CNN reporter for that important discussion.)

Once journalists begin to understand the definitive nature of Molecular Genomics science, then they can start to grasp just what one researcher has been able to do with it.

...............

Research side notes:
Diets of rodents may have tainted decades of research
Concerned scientists to meet, discuss effects of hormones in chow
11:34 PM CDT on Tuesday, August 1, 2006
By SUE GOETINCK AMBROSE / The Dallas Morning News
..................

An educated populace that is willing to take action is all that stands between corruption and correction.--Janet



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ShrnHml
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 Posted: Sat Nov 11th, 2006 16:30

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Frans.........I never cease to be amazed at your grasp of the science and especially your ability to put it into readable format. All of this while operating in a "foreign" language. Thank you for your posts.           .................Sharon



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Brad
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 Posted: Sat Nov 11th, 2006 19:55

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Greg,

Thanks so much for the links, I missed reading that post by Joyce, now when I read the words innate and adaptive I will be able to somewhat follow along.

Paulette



____________________
CFS/FM 12years, Oct1/04-cut D-exp Oct25/04Noirs Jan3/05 Benicar40mgQ6H Jan19-25mg mino July9/05 2nd abx 100mg voltaren Nov17/04 1,25D-33.5, 25D-16.4, D-ratio=2 July/05 25D-2.5ng/ml

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