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The Marshall Protocol Study Site > PROF. MARSHALL'S PERSPECTIVE > Prof. Marshall's Perspective > Chlorogenic Acid in Coffee is powerful Immune modulator


Chlorogenic Acid in Coffee is powerful Immune modulator
 Moderated by: Prof Trevor Marshall Page:  First Page Previous Page  ...  6  7  8  9  10  11  12  13  14  15  16  ...  Next Page Last Page  
 

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Prof Trevor Marshall
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 Posted: Sat Jan 19th, 2008 20:59

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It is reasonable to expect that any method of processing coffee beyond the usual roasting and grinding occurs for a purpose. Given the large number of folk who are not feeling well these days (from low-level immune disease) you should expect that some degree of 'feeling better', and some degree of physical dependence, is involved in the extra processing effort.
 
Best to get rid of the bugs causing the problem, and then it all tastes nice again...
 

migsies
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 Posted: Wed Jan 23rd, 2008 18:49

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Has anyone seen the recent Kaiser study linking caffeine (two cups of coffee or more, roughly?) and increased risk of miscarriage? The authors seem puzzled as to causal factors. Could it be the VDR is involved?;)



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Toni D
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 Posted: Wed Jan 23rd, 2008 21:28

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I saw the piece on TV.  How I wish someone would open their eyes and look at the invaluable info offered by Dr. M's many many years of research.  It would be nice if we could get a spot on the morning news ...then Oprah ...Dr. Phil (if he's still around) ...20/20.  



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Prof Trevor Marshall
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 Posted: Wed Jan 23rd, 2008 21:45

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Toni,
I can travel anywhere, at any time :):)
 

Toni D
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 Posted: Wed Jan 23rd, 2008 22:06

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Wish I was in that circle~~would be my honor to network you/MP.  It's coming though, I can see it.  The vision is yet for an appointed time ...at the end it shall speak and not lie.  We [MP community] won't tarry much longer:D.



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Claudia
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 Posted: Wed Jan 23rd, 2008 22:56

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Yes, i just saw a reference to that in a newspaper yesterday in Australia, and wondered the same thing.



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wrotek
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 Posted: Thu Jan 24th, 2008 11:23

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http://tinyurl.com/2f644k

Azole antimycotics differentially affect rifampicin-induced Pregnane X Receptor (PXR)-mediated CYP3A4 gene expression

Azole antifungal drug ketoconazole has recently been demonstrated as an inhibitor of a ligand-induced PXR-mediated transcriptional regulation of CYP3A4 gene through disruption of PXR interaction with steroid receptor coactivator-1 (SRC-1). In contrast, other clotrimazole-derived antifungal agents are known as potent inducers of CYP3A4 through PXR.
So, ketokonazole is different from other Azole's.

Last edited on Thu Jan 24th, 2008 11:24 by wrotek



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Prof Trevor Marshall
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 Posted: Thu Jan 24th, 2008 11:48

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Ah, but is there anything published yet about Metronidazole (Flagyl) and PXR?
 

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 Posted: Thu Jan 24th, 2008 11:49

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Does this mean we should or should not use the K-creme?

In puzzlement,

Sherry



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Prof Trevor Marshall
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 Posted: Thu Jan 24th, 2008 12:09

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This implies that it is likely that K-Cream is working as an local, topical, immunosupressant, which I have always said it does, since it has affinity for the VDR as well as the PXR.
 

wrotek
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 Posted: Thu Jan 24th, 2008 12:12

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Dr Marshall, i have yet found only that metronidazole is among chemicals in table http://en.wikipedia.org/wiki/CYP3A4 as "unspecified CYP3A4 antagonist" (enigmatic description for me ).
But I can't find where this information came from, cause wikipedia (about metronidazole) does not say anything about it.

Last edited on Thu Jan 24th, 2008 12:16 by wrotek



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Prof Trevor Marshall
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 Posted: Thu Jan 24th, 2008 12:14

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LOL, good ol' unreliable Wackypedia. See if you can find any 'original research paper':)

 

wrotek
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 Posted: Thu Jan 24th, 2008 12:33

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LOL it is a challenge no questions about it, cause i can' find anything and i try hard :).
But i have found something else about ketoconazole http://tinyurl.com/yufucr

Activated pregnenolone x-receptor is a target for ketoconazole and its analogs.

These studies show that some azole compounds repress the coordinated activation of genes involved in drug metabolism by blocking PXR activation
and another one...

http://www.nature.com/onc/journal/v26/n2/abs/1209788a.html

Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole

We have found that xenobiotic-mediated induction of CYP3A4 and MDR-1 gene transcription was inhibited by ketoconazole, a commonly used antifungal drug. Ketoconazole mediated its effect by inhibiting the activation of NRs, human pregnenolone X receptor and constitutive androstene receptor, involved in regulation of CYP3A4 and MDR-1. The effect of ketoconazole was specific to the group of NRs that control xenobiotic metabolism. Ketoconazole disrupted the interaction of the xenobiotic receptor PXR with the co-activator steroid receptor co-activator-1. Ketoconazole treatment resulted in delayed metabolism of tribromoethanol anesthetic in mice, which was correlated to the inhibition of PXR activation and downmodulation of cyp3a11 and mdr-1 genes and proteins. These studies demonstrate for the first time that ketoconazole represses the coordinated activation of genes involved in drug metabolism, by blocking activation of a specific subset of NRs. Our results suggest that ketoconazole can be used as a pan-antagonist of NRs involved in xenobiotic metabolism in vivo, which may lead to novel strategies that improve drug effect and tolerance.

Last edited on Thu Jan 24th, 2008 14:42 by wrotek



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Prof Trevor Marshall
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 Posted: Thu Jan 24th, 2008 15:38

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CYP3A4 is listed in Wang et al's supplemental table 4 as one of the 27,000 genes possibly transcribed by VDR, so it is certainly possible that PXR could actually be the transcription factor. Or maybe a PXR-VDR heterodimer. Who knows?
 

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 Posted: Thu Jan 24th, 2008 22:10

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Do I understand this material correctly that Ketoconazole, an anti-fungal, is immunosuppressive?

I wonder if this action that Ketoconazole works is reason that a German (?) doctor was able to make some borreliosis patients FEEL better and get them off government support roles by using Diflucan, an anti-fungal.

The use of Diflucan was a "hot thing" for borreliosis/Lyme in 2004.

I tried Diflucan for a short period pre-MP, but found that it did not do anything for me.

Wishing all wellness!!! :)

Dark Vader...aka, George



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Prof Trevor Marshall
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 Posted: Thu Jan 24th, 2008 23:18

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Yes, George, that is exactly our point. Diflucan has a profound effect on the human body, not just on fungal pathogens. See, for example http://tinyurl.com/yolbh9
 
The effect on the body's enzymes is exacerbated at the high concentrations typcally used by the Lyme Literate Physicians (LLMD).
 

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 Posted: Fri Jan 25th, 2008 05:58

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OK, I've been wanting to ask this for a long time: some fungi are capable of manufacturing vitamin D, and apparently they do this when exposed to sunlight. Apart from wondering what use the compound is to the fungus, I wonder if our skin is doing anything like the same thing, chemically speaking. Since we are using K-cream, which is supposed to kill fungus, is it interfering with the same process in our skin (or similar) as it affects the fungus?
I know you may have already explained it above, but can I have it in English, please?
Are we - :shock: shock, horror - really a bunch of mushrooms, too?

Or just a coincidence?

:dude: Claudia - sitting in the dark, decomposing.



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Prof Trevor Marshall
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 Posted: Fri Jan 25th, 2008 11:52

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The VDR Nuclear Receptor is ancient.
For example, the Lamprey has a VDR. How it manufactures the Vitamin D to activate its VDR beneath the waters of the Great Lakes is something I will leave our Canadian Vit D fanatics to figure out :):):)

http://www.ncbi.nlm.nih.gov/pubmed/12746335

I haven't done much work with yeast, my focus has been on mammals. So I can't tell you if there is a VDR homologue in yeast. Probably is, though,as there is in Drosophila... You might like to review this:
http://www.biomedcentral.com/1471-2148/7/222

As far as K Cream is concerned, it doesn't much care if you are yeast, a mushroom, a mouse or a human, it will mess with your VDR and enzymes as much as it can. That is why it is toxic, if ingested in quantity.
 

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 Posted: Fri Jan 25th, 2008 12:55

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I'm not sure if the Canadian Vitamin D fanatics will ever figure it out.

There is so much Vitamin D in the food supply in Canada most of the country seems to be walking around in a Vitamin D induced haze.  



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sunflower
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 Posted: Fri Jan 25th, 2008 13:42

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i have taken diflucan in the past, two separate times (100 mg day/or qod), for many months to treat chronic candidiasis....i always felt so horrible while on it.  i just assumed it was massive herxing from the dying off of the yeast, but maybe something alot more sinister was going on :shock:.  other than suppressing the immune system and allowing the l-form bacteria to proliferate, do you think the drug could have caused permanent damage to my body?   thanks....sun

Last edited on Fri Jan 25th, 2008 15:34 by sunflower



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