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The Marshall Protocol Study Site > PROF. MARSHALL'S PERSPECTIVE > Prof. Marshall's Perspective > Chlorogenic Acid in Coffee is powerful Immune modulator


Chlorogenic Acid in Coffee is powerful Immune modulator
 Moderated by: Prof Trevor Marshall Page:  First Page Previous Page  ...  26  27  28  29  30  31  32  33  34  35  36  ...  Next Page Last Page  
 

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seanlane
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 Posted: Wed Jun 6th, 2012 20:07

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http://www.huffingtonpost.com/2012/06/07/coffee-alzheimers-disease-onset-caffeine_n_1571090.html

They are saying it's the caffeine that delays the onset of alzheimers....I thought it was the Chorogenic acid?



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wrotek
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 Posted: Thu Jun 7th, 2012 02:28

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Yeah it looks like they are using coffee for study very often

It would mean that folks in Britain would have different alzheimer outcomes, since they are tea drinkers I think.

Last edited on Thu Jun 7th, 2012 02:29 by wrotek



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keithw
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 Posted: Thu Jun 7th, 2012 15:14

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Hmmm, I wonder who was behind that study, certainly not a tea drinker!;)

Personally I credit Rooibos tea (no caffeine) for keeping my mental faculties sharp but what do I know?:shock:

:dude:



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Lee
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 Posted: Fri Jun 8th, 2012 05:33

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My mother was sharp up until her death at 85 and drank a few cups of real coffee daily.  My step-dad had to use de-caff products due to heart problems and a pace-maker.  He passed of late onset Alzheimers at 87 ...:(  Needless to say I still covet a little "real coffee" daily!  Lee



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Daki
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 Posted: Sat Jun 9th, 2012 10:34

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What about a cup of tea /better tea-pot/? ;)
I drink much tea a day, but thin and with milk. Pure green china tea and exclusively bulk /no dust in bags/.
I  have not drunk coffee the third summer now. I feel much more fresh and coffee of poor quality smell me.:? 

Last edited on Sat Jun 9th, 2012 11:07 by Daki



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Lee
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 Posted: Sat Jun 9th, 2012 11:19

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I love green tea!  After my tiny cup of coffee I make a large glass of green tea using one bag and dilute this throughout the day until is is plain water.  As TM suggests I only steep the bag a short time, perhaps 1-2 minutes.  When the weather is very hot, like now, I do forget the coffee as it is not worth heating up the RV to make coffee.  Lee



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Daki
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 Posted: Sat Jun 9th, 2012 13:18

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Good idea, Lee. Change tea for coffee. But sometimes is difficult to fall asleep when drink tea continuosly through whole day.
Daki



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Lee
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 Posted: Sat Jun 9th, 2012 14:16

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Decaff, Daki ....:P



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laura1814
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 Posted: Thu Jul 5th, 2012 11:14

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I had an experience with the palliative effects of (decaf) coffee last week. I posted about it in great detail in my progress thread if anyone is interested.



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wrotek
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 Posted: Thu Aug 23rd, 2012 04:41

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Growth regulation of the vascular system: an emerging role for adenosine

Abstract The importance of metabolic factors in the regulation of angiogenesis is well understood. An increase in metabolic activity leads to a decrease in tissue oxygenation causing tissues to become hypoxic. The hypoxia initiates a variety of signals that stimulate angiogenesis, and the increase in vascularity that follows promotes oxygen delivery to the tissues. When the tissues receive adequate amounts of oxygen, the intermediate effectors return to normal levels, and angiogenesis ceases. An emerging concept is that adenosine released from hypoxic tissues has an important role in driving the angiogenesis. The following feedback control hypothesis is proposed: AMP is dephosphorylated by ecto-5′-nucleotidase, producing adenosine under hypoxic conditions in the extracellular space adjacent to a parenchymal cell (e.g., cardiomyocyte, skeletal muscle fiber, hepatocyte, etc.). Extracellular adenosine activates A2 receptors, which stimulates the release of vascular endothelial growth factor (VEGF) from the parenchymal cell. VEGF binds to its receptor (VEGF receptor 2) on endothelial cells, stimulating their proliferation and migration. Adenosine can also stimulate endothelial cell proliferation independently of VEGF, which probably involves modulation of other proangiogenic and antiangiogenic growth factors and perhaps an intracellular mechanism. In addition, hemodynamic factors associated with adenosine-induced vasodilation may have a role in the development and remodeling of the vasculature. Once a new capillary network has been established, and the diffusion/perfusion capabilities of the vasculature are sufficient to supply the parenchymal cells with adequate amounts of oxygen, adenosine and VEGF as well as other proangiogenic and antiangiogenic growth factors return to near-normal levels, thus closing the negative feedback loop. The available data indicate that adenosine might be an essential mediator for up to 50–70% of the hypoxia-induced angiogenesis in some situations; however, additional studies in intact animals will be required to fully understand the quantitative importance of adenosine.
Since we are dealing with vascular problems, CCSVI for example...

Last edited on Thu Aug 23rd, 2012 04:42 by wrotek



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wrotek
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 Posted: Thu Sep 6th, 2012 15:08

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http://www.vitasearch.com/get-clp-summary/37363
GLUCOSE HOMEOSTASIS, DIABETES TYPE 2 - Coffee, Caffeine, Insulin


"Caffeinated coffee consumption impairs blood glucose homeostasis in response to high and low glycemic index meals in healthy men," Moisey LL, Kacker S, et al, Am J Clin Nutr, 2008; 87(5): 1254-61. (Address: Terry E. Graham, Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1. E-mail: terrygra@uoguelph.ca ).


 In a study involving 10 healthy men, consumption of caffeinated (5 mg/kg) coffee was found to impair acute blood glucose management and insulin sensitivity. Subjects consumed either caffeinated (5 mg/kg body weight) coffee or decaffeinated coffee, followed by a 75 gram oral glucose load (either a high glycemic index (GI) cereal or a low GI cereal mixed meal tolerance test), one hour later. Results found that compared to consuming decaffeinated coffee prior to the high GI meal, when subjects consumed caffeinated coffee followed by the high GI meal, areas under the curve were higher for glucose (147%), insulin (29%), and C-peptide (40%). After consumption of the low GI meal, areas under the curve were also greater for glucose (216%), insulin (44%), and C-peptide (36%), when caffeinated coffee had been consumed. Moreover, insulin sensitivity was significantly reduced (by 40%) when the high GI meal was consumed following caffeinated coffee, and it was reduced by 29% after consumption of the low GI meal. The authors conclude, "Future investigations are warranted to determine whether caffeinated coffee is a risk factor for insulin resistance."



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wrotek
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 Posted: Fri Sep 28th, 2012 11:37

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coffee & gluten

http://drclark.typepad.com/dr_david_clark/2011/09/coffee-and-gluten-sensitivity-surprising-news.html

It would make sense since coffee berries are seeds

Last edited on Fri Sep 28th, 2012 11:44 by wrotek



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norman
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 Posted: Fri Sep 28th, 2012 12:01

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Fascinating ! I am going to get tested shortly ...see what happens

wrotek
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 Posted: Sat Sep 29th, 2012 03:36

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norman wrote: Fascinating ! I am going to get tested shortly ...see what happensTest what and how ?



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wrotek
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 Posted: Sun Sep 30th, 2012 02:31

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Coffee promotes cortisol production and weight gain
http://www.naturalnews.com/034674_coffee_cortisol_weight_gain.html

This cortisol-induced demand for blood sugar causes us to feel hungry, encouraging us to eat more despite our best intentions.

Some people eat a lot when stressed, right ? Women eat ice cream by buckets :)

Last edited on Sun Sep 30th, 2012 02:33 by wrotek



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Cynthia S
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 Posted: Sun Sep 30th, 2012 08:22

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Women?  It is my significant other that is the ice cream-holic in the family.  Cynthia



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wrotek
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 Posted: Sun Sep 30th, 2012 09:00

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Cynthia Schnitz wrote: Women?  It is my significant other that is the ice cream-holic in the family.  Cynthia
Base on what I saw in the movies :D
When woman has boyfriend problem, she devours bucket full of ice-cream. And it is always big bucket.

Last edited on Sun Sep 30th, 2012 09:01 by wrotek



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Cynthia S
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 Posted: Sun Sep 30th, 2012 10:30

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Male screen writers no doubt.  Cynthia



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eClaire
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 Posted: Wed Oct 3rd, 2012 05:14

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I've been following all of this with interest.

I never drank coffee and only discovered that I liked it a couple of months before starting the MP. A few years into the MP, I started having a cup every two weeks.

Last winter (early March), I found that having about 5 cups a week in the morning resulted not only in better energy for the entire day (taking a break every two or three days) but a more normal sleep pattern.

When I pushed myself too much while my mother was dying and shortly there after (month of July), I experienced a crash and stopped the coffee. I also put on 12 pounds after stopping the coffee (I am assuming that the weight gain was part consolation eating and part the CFS crash, as crashes in the past have always resulted in quick weight gain for me).

I have CFS and people with CFS have abnormally low cortisol levels in the morning, which screws with our sleep. Also, we have poor carbohydrate metabolism.

Feeling more rested from mostly bed rest 24/7, I began drinking coffee in the morning again on Monday and have had more energy and slept much better, feeling more rested from the sleep I am getting (versus not feeling rested at all from the sleep I was getting). Going from 2 to 4 hours of sleep a night to 5 to 8. The day I drank my coffee around noon, I got a poor night's sleep.

I'm continuing with the MP (40mg Benicar q5h), of course, but wonder what my 5 cups a coffee a week might be doing to me... whether it might actually be hurting me.


Last edited on Wed Oct 3rd, 2012 05:19 by eClaire



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Cynthia S
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 Posted: Wed Oct 3rd, 2012 10:32

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Have you experimented to see what effect decaffeinated coffee does?  Is the desirable part the caffeine, or something else like the chlorogenic acid?  I also have to limit my high octane coffee to at least before 3 pm, or I don't sleep.  Decaffeinated is OK later in the day tho.  Dr. Marshall says that coffee has no effect on him now.  Cynthia



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