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The Marshall Protocol Study Site > PROF. MARSHALL'S PERSPECTIVE > Prof. Marshall's Perspective > Chlorogenic Acid in Coffee is powerful Immune modulator


Chlorogenic Acid in Coffee is powerful Immune modulator
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jrfoutin
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 Posted: Mon May 21st, 2018 19:45

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Managing perceptions of immunopathology required for healing can get derailed with chronic dependence on favorite palliations. (Opioid receptor possibility may be involved.)

Terms to google research in scholarly articles [any one favorite palliation choice made daily for years without a break or change of palliation type that hits hormones is worth looking into... I found a lot for different compounds in coffee]:

nociceptive
relating to or denoting pain arising from the stimulation of nerve cells (often as distinct from that arising from damage or disease in the nerves themselves).

antinociceptive
the action or process of blocking the detection of a painful or injurious stimulus by sensory neurons. Compared with systemic narcotic analgesia, intraspinal narcotic antinociception has a longer duration.

Olmesartan acts on the super-hormone famiy receptor D, but full pathways within the super-hormone family group may have complexities and correlations worthy of avoiding palliation (especially when dependencies exist of never changing from one palliation to another over time on the MP).

Weaning from all palliations might offer the best perception clarity.

A regular consumption habit of any one palliation daily, especially in large quantities, might not stop all the good that olmesartan can do. But what progress might be made without palliation is not known without weaning.

Best to all--Janet

Last edited on Mon May 21st, 2018 19:59 by jrfoutin



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 Posted: Mon May 21st, 2018 22:56

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Not sure how to distinguish neuro and fatigue.  Probably both, have neither the will nor the energy to get up & do things without coffee.



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 Posted: Wed May 23rd, 2018 14:10

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https://drive.google.com/open?id=1PUoLY4ey7JWZgo6WcSV0TyVDBC8Z34j3Adenosine acting on A 2a receptors suppresses IL-12 production by mature DCs leading to diminished
Th1- versus Th2-cell development


page 5 of this document.

Last edited on Wed May 23rd, 2018 14:10 by wrotek



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 Posted: Wed May 23rd, 2018 14:23

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So basically coffee shifts from Th1 to Th2?



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 Posted: Wed May 23rd, 2018 14:24

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No. Caffeine blocks adenosine that is supposed to shift. Caffeine blocks all 4 adenosine receptors, nonspecifically

Last edited on Wed May 23rd, 2018 14:24 by wrotek



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 Posted: Wed May 23rd, 2018 14:29

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Interesting...

Also
https://www.ncbi.nlm.nih.gov/pubmed/18625677

Adenosine is an immunosuppressive nucleoside, and adenosine A(2A) receptors inhibit T-cell activation. We investigated the role of A(2A) receptors in regulating T helper (Th)1- and Th2-cell development and effector function. A(2A)-receptor stimulation suppressed the development of T-cell receptor (TCR) -stimulated naive T cells into both Th1 and Th2 cells, as indicated by decreased IFN-gamma production by cells developed under Th1-skewing conditions ...
...
Using in vivo established Th1 and Th2 cells, we further demonstrate the nonselective nature of A(2A) receptor-mediated immunosuppressive effects
...



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 Posted: Wed May 23rd, 2018 15:22

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yes a2a is antiinflammatory, but other receptors can be proinflammatory. So adenosine system also facilitates inflammation to elliminate bacteria.

Last edited on Wed May 23rd, 2018 15:25 by wrotek



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jrfoutin
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 Posted: Wed May 23rd, 2018 18:20

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If we look at outcomes, it seems reasonable to consider that gateways and paths controlled by healthy homeostasis are susceptible to ingested compounds, especially complex compounds with highly atypical ranges for chlorogenic acid, like coffee, that are known to circumvent normal systems controls and homeostasis required for health.

Coffee (caffeinated or not) is a complex mess of compounds (read all posts above, starting with Dr Marshall's).

Coffee is also known to be addictive but caffeine doesn't seem to be the main culprit here, just a happy add-on booster pack that encourages us to think we are not being robbed of energy or well being.

Coffee also plays tricks on nerve signal perceptions (nociceptive/antinociceptive), so one might not really know what is going on with their own recovery or not. Those on the MP depend on accurate sensory neuron detection of painful or injurious stimulus to adjust olmesartan or even know if they are improving over time. With coffee on board at regularly ingested intervals or high amounts via dependencies, we might expect to have extreme difficulty accurately reporting 1-10 scale details.

With coffee on board, we can't trust our signals to accurately report improvement. (Never mind research accuracy that depends on 1-10 self-reporting scales in small cohorts.)

Even with our own personal notes/charts or offering our very expensive and elaborate EMF/RFR blocking devices to achieve a clearer wave environment to chart/note, it makes very little research-accuracy sense to toss in regular coffee consumption or to suggest it is an innocent "palliation."

We might also want to avoid the far too misleading label of "palliation" at all, especially with opiates, coffee, hormones or other Rx that control sensory nerve signals with Central processing complexity (not so simple or direct as intracellular signals, and absolutely involved in what we report on with 1-10 charting or choices we make to manage pain or severe symptoms).

But that is something I've thought about while reading the discussion on this thread. I could be wrong. Thank you all for your study and insights.

Best to all--Janet



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 Posted: Thu Feb 7th, 2019 09:43

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Caffeine and Selective Adenosine Receptor Antagonists as New Therapeutic Tools for the Motivational Symptoms of Depression
https://www.frontiersin.org/articles/10.3389/fphar.2018.00526/full
Major depressive disorder is one of the most common and debilitating psychiatric disorders. Some of the motivational symptoms of depression, such anergia (lack of self-reported energy) and fatigue are relatively resistant to traditional treatments such as serotonin uptake inhibitors. Thus, new pharmacological targets are being investigated. Epidemiological data suggest that caffeine consumption can have an impact on aspects of depressive symptomatology. Caffeine is a non-selective adenosine antagonist for A1/A2A receptors, and has been demonstrated to modulate behavior in classical animal models of depression. Moreover, selective adenosine receptor antagonists are being assessed for their antidepressant effects in animal studies. This review focuses on how caffeine and selective adenosine antagonists can improve different aspects of depression in humans, as well as in animal models. The effects on motivational symptoms of depression such as anergia, fatigue, and psychomotor slowing receive particular attention. Thus, the ability of adenosine receptor antagonists to reverse the anergia induced by dopamine antagonism or depletion is of special interest. In conclusion, although further studies are needed, it appears that caffeine and selective adenosine receptor antagonists could be therapeutic agents for the treatment of motivational dysfunction in depression.

Caffeine's effect on the brain's adenosine receptors visualized for the first time
https://www.eurekalert.org/pub_releases/2012-11/sonm-ceo110112.php
An important finding of the study is that in most regular coffee drinkers about half of the A1 adenosine receptors may be occupied by caffeine.


Caffeine acts through neuronal adenosine A2A receptors to prevent mood and memory dysfunction triggered by chronic stress

https://www.pnas.org/content/112/25/7833
Epidemiological studies show that individuals exposed to repeated stress, a major trigger of depression, increase their caffeine intake, which correlates inversely with the incidence of depression. However, the mechanism underlying this protective effect is unknown. We used an animal model of chronic unpredictable stress (CUS) to show that caffeine prevents the maladaptive changes caused by CUS in a manner mimicked by the selective blockade of adenosine A2A receptors (A2AR). CUS enhanced A2AR in synapses, and the selective elimination of neuronal A2AR abrogated CUS modifications. Moreover, A2AR blockade also afforded a therapeutic benefit, paving the way to consider A2AR blockers as a strategy to manage the negative impact of chronic stress on mood and memory.

...

Common ground between adenosine and caffeine:

http://file.scirp.org/Html/1-1410154_59387.htm
Caffeine and adenosine significantly reduced the amount of TNFα and IL-12 produced by LPS-stimulated monocytes.
...
It is worth noting that in all cases the decreased TNFα level caused by caffeine was greater than that caused by adenosine. This reinforces the possibility that caffeine is an immune-modulatory molecule.
...
It is worth noting that the combination of adenosine and caffeine decreased TNF-α levels more than when each reagent was used alone.

Last edited on Thu Feb 7th, 2019 10:51 by Dmitry



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 Posted: Thu Feb 7th, 2019 09:51

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Caffeine helps stress?? :)



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 Posted: Thu Feb 7th, 2019 09:53

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wrotek wrote:
Caffeine helps stress?? :)

:) https://www.youtube.com/watch?v=jOfquPE1cnU



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 Posted: Thu Feb 7th, 2019 18:04

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I'm reminded that something modulating (often in very questionable ways) key functions critical to heart, brain and kidneys while being an extremely popular addiction (to the point of a youtube video maker assuming the primary reason Europe in the 1500's did anything worthy of history was coffee houses), is really tempting to buy into.

"Does something significant chemically that is just starting to be studied in animals" and "good for you" are not necessarily the same thing.

The full story of chlorogenic acid combined with caffeine and typical massive consumption habits (many daily big cup deliveries into the multiple quart arena) might not be a good idea to buy into just because modulation occurs with a drug that doesn't legally require a script or boundary limits.



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 Posted: Thu Feb 7th, 2019 18:52

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What do you mean by this video



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 Posted: Fri Feb 8th, 2019 15:37

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Seeing a lot of nutritional products touting Green Coffee Bean/CGA for weight loss or whatever.  I don't have a very good feeling about it.



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 Posted: Fri Feb 8th, 2019 19:47

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https://www.google.com/search?num=100&site=&q=Friedlieb+Ferdinand+Runge&oi=ddle&ct=friedlieb-ferdinand-runges-225th-birthday-4887536710189056-law&hl=pl&kgmid=/m/02yxnq&sa=X&ved=0ahUKEwicv5L_gK3gAhUuMuwKHc2LDeMQPQgF&biw=1245&bih=741&dpr=1.1

https://pl.wikipedia.org/wiki/Friedlieb_Ferdinand_Runge


is this true ? google promotes it

Last edited on Fri Feb 8th, 2019 19:48 by wrotek



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 Posted: Sat Feb 9th, 2019 17:11

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Why cardiac surgeons do not drink tea, coffee(in Russian). The day a famous heart surgeon celebrated his 75th birthday. Video about the secret of his health and work performance. https://www.youtube.com/watch?v=WklJLoRfy8g

He said:

I have an example of American cardio surgeons: they do not drink coffee, strong tea because at some point the hand tremor occurs and this is a very serious warning for a person who wants to operate for a long time and efficiently. I don’t drink coffee at all - coffee gives a tremor.

Adenosine: a selfish-immunity signal?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741691/
We further showed that lamellocytes precursors released adenosine that suppressed the consumption of glucose by non-immune tissues and thus slowed down the host development. When we blocked adenosine signaling or its release from immune cells, the development proceeded with normal speed but the resistance against parasitoid dropped, demonstrating a trade-off between development and the immune response. In our experimental system, immune cells use adenosine as a selfish signal to usurp energy from the rest of the organism, which is a vital strategy during infection.
...
Can adenosine play a similar role in higher organisms including humans? Adenosine is produced, for example, by activated neutrophils and its systemic level is increased during sepsis. Adenosine generally suppresses energy-consuming processes; this can be observed both at the cellular level, e.g. inhibiting cell growth, and at the systemic level. The systemic suppression effects of adenosine are observed in torpor/hibernation and are important for anoxia-tolerant organisms. Adenosine is known to suppress neuronal firing and to induce sleep; caffeine is the most famous adenosine receptor antagonist. Increased plasma levels of adenosine were associated with chronic fatigue syndrome and adenosine was shown to mediate an exercise-induced fatigue [5]. Fatigue is a hallmark of sickness and thus it is tempting to speculate that adenosine may cause fatigue in proportion to tissue damage and the energy needs of immune cells. Fatigue and suppressing the overall activity of the organism could form, together with insulin resistance, a complex program to conserve energy for the immune system.


Central nervous system effects of caffeine and adenosine on fatigue.
https://www.ncbi.nlm.nih.gov/pubmed/12399249
Caffeine ingestion can delay fatigue during exercise, but the mechanisms remain elusive. This study was designed to test the hypothesis that blockade of central nervous system (CNS) adenosine receptors may explain the beneficial effect of caffeine on fatigue. Initial experiments were done to confirm an effect of CNS caffeine and/or the adenosine A(1)/A(2) receptor agonist 5'-N-ethylcarboxamidoadenosine (NECA) on spontaneous locomotor activity. Thirty minutes before measurement of spontaneous activity or treadmill running, male rats received caffeine, NECA, caffeine plus NECA, or vehicle during four sessions separated by approximately 1 wk. CNS caffeine and NECA (intracerebroventricular) were associated with increased and decreased spontaneous activity, respectively, but caffeine plus NECA did not block the reduction induced by NECA. CNS caffeine also increased run time to fatigue by 60% and NECA reduced it by 68% vs. vehicle. However, unlike the effects on spontaneous activity, pretreatment with caffeine was effective in blocking the decrease in run time by NECA. No differences were found after peripheral (intraperitoneal) drug administration. Results suggest that caffeine can delay fatigue through CNS mechanisms, at least in part by blocking adenosine receptors.

Last edited on Sat Feb 9th, 2019 17:19 by Dmitry



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 Posted: Sat Feb 9th, 2019 19:15

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....that's why I drink Melitta, Classic Lite, reduced Caffeine and Acidity and have for years!!!! I wrote The Marshall Protocol about it years ago



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 Posted: Sun Feb 10th, 2019 10:02

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https://legacychocolates.com/about-us/blog/articleid/10/whats-the-buzz-caffeine-facts-about-chocolate-vs-coffee
Let's take a look at the caffeine in coffee: eight ounces of generic brewed coffee contains around 95 milligrams of caffeine. A sixteen-ounce cup of good coffee – the “grande” size in many coffee shops – has between 200 and 300 milligrams of the stimulant. Even the standard one-ounce shot of espresso from a coffee shop averages 75 milligrams of caffeine. That's a lot of buzz packed into a small volume.

So what about chocolate? A one-ounce square of unsweetened baking chocolate contains 23 milligrams of caffeine. If you look at a large, 3.5-ounce bar of very dark chocolate (70-85% cocoa), you'll find around 80 milligrams of caffeine. A similar bar of plain milk chocolate averages 20 milligrams of caffeine. Hot cocoa only has about nine milligrams per eight-ounce cup.


Does Hot Chocolate Have Caffeine? How It Compares to Other Beverages
https://www.healthline.com/health/food-nutrition/does-hot-chocolate-have-caffeine#hot-chocolate-vs.-tea
...
Black tea: 1 cup (8 oz.) contains 25-48 mg of caffeine
Green tea: 1 cup (8 oz.) contains 25-29 mg of caffeine
...

Last edited on Sun Feb 10th, 2019 10:06 by Dmitry



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 Posted: Tue Feb 12th, 2019 10:32

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Interesting caffeine info and additional links from this page are about more than just candy (although candy is an interesting subcategory on the page):

https://www.caffeineinformer.com/caffeine-in-candy

Although the listing for amount of caffeine can be shockingly high in many common sources, it helps to look at the amount being measured. One coffee bean in expresso might be a tad shy to achieve a full cup, for example. Some mints and even marshmallows are rarely a "just one" edible. A small square of dark chocolate bar is not usually a full portion eaten, where a cup of Hershey's cocoa with one tablespoon of cocoa is a rational single serving amount (a big difference between total amount of caffeine ingested might be achieved by examining what a "normal" amount is typically eaten, in other words).

When examining decaf, do look at the actual amounts of caffeine. Melitta lite, for example, advertises as having 40% less caffeine than regular coffee, but a little math suggests that also means it likely delivers 60% caffeine content found in regular undecaffinated coffee (if regular contains 163mg, then Melitta lite would contain roughly 98mg caffeine per typical serving, still a whopping lot. This is about the same as Hydroxycut hardcore-100mg, a piece of Military Energy gum-100mg, a tube of Nuclear Energy Powder-90mg, one Ritual Energy Bar-100mg, or even more than a combination of 8oz of Ben and Jerry's coffee ice cream-70mg PLUS 1T powder per each of 2 cups of Hershey's hot cocoa at 9mg per cup).

Nootropics (brain booster) supplements are typically packed with caffeine, too. Smoke and mirror illusions and skillful content risk minimization per the centuries-long embedding of caffeine in socially-accepted ingestion routines are excellent marketing tools.

Sadly, many problematic foodstuffs exist, making buyer-beware difficult even for those who really try to avoid trouble. For example of making choices, Blast caffeine packets at 11000mg a single serve packet might be considered a far more serious recipe for disaster as a single daily dose than Melita lite-98mg or even a cup of Hershey's Cocoa-9mg, by comparison, but all must decide how much risk they want to carry and how frequent they want to ingest any caffeine.

Thank you for the discussion. I've learned a lot.



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 Posted: Thu Feb 14th, 2019 13:36

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People dont know but caffeine is mostly converted into paraxantine, which has similar half like to caffeine and similar effects. So most discomfort is on the day 3 after stopping



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