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Prof Trevor Marshall
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Yesterday a journalist suggested we should have something up on YouTube so it could be easily incorporated into a blog.

It is in two 35-minute segments at URLs:
http://www.youtube.com/watch?v=RpocxjKJxag
http://www.youtube.com/watch?v=ZMn-zUTTHgw

A slightly higher resolution version is in 8 segments:
http://www.youtube.com/watch?v=-FzYARFQ9ZE
http://www.youtube.com/watch?v=7RVXgEOBASo
http://www.youtube.com/watch?v=ngfOyXdfDn4
http://www.youtube.com/watch?v=BmPHSI3YoSM
http://www.youtube.com/watch?v=j8Is2bFyx_0
http://www.youtube.com/watch?v=08TF7qPNs2A
http://www.youtube.com/watch?v=zpXIFJ3t-zU
http://www.youtube.com/watch?v=MdmrKCcvnzI

Please feel free to let your favorite journalist/blogger know about the new material.

remember that the written transcript PDF is at
http://www.autoimmunityresearch.org/transcripts/marshall_aaem_2006.pdf

..Trevor..

ps: An uninterrupted copy of the presentation is now available from Google video. The quality is not quite as good as YouTube, as Google insists on doing their own video processing, so I was not able to use the latest technological tricks to make the slides easy-to-read.
http://video.google.com/videoplay?docid=-2390315864442431912

The YouTube videos can also be embedded into a webpage or blog.
 

Last edited on Tue Dec 18th, 2007 11:16 by Prof Trevor Marshall

wrotek
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Dr Marshall you can put your presentation on video.google.com, no limits there.
I know youtube and google are connected, but if one will use google video uploader(no MB limits) or web uploader (only up to 150 MB i guess), there are no limits.

Last edited on Sat Sep 29th, 2007 21:31 by wrotek

jcwat101
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That's great!
 
If you contact someone with the YouTube link you might also want to include the link to Amy and Paul's site:  http://www.bacteriality.com
 
Joyce

wrotek
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I have been watching presentation again and wondering, is it possible for different bacterium to acquire borrelia plasmids and stimulate anti-borrelia antibodies when borrelia alone was eradicated ?
Won't new bacterium with borrelia plasmid genes, become partially a borrelia ?

Last edited on Sun Sep 30th, 2007 00:43 by wrotek

Prof Trevor Marshall
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Wrotek,
The answer is yes, proteins transcribed from plasmids will follow the plasmids. But in addition, antibodies are not that specific. At the 2004 Autoimmunity conference, a group from Stanford gave a presentation where they showed hundreds of molecules, from tiny ones all the way to large proteins, which could bind to a single antibody.

Antibodies are useful in a diagnostic environment, but not precise. PCR is better, but still imprecise until we know all the bacterial genomes... Only full genome sequencing is reliable, and that is very hard to do in a metagenomic community.
 

mysevenkids
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hi joyce,

i have question, not sure if i am posting correctly yet, havent used the list very often.

if some one has a birth defect or condition from birth, how would it be possible to fix it with antibotics? it seems the problem is structure if somthing didnt form correctly, and say even if it is from bacteria cause from the start, once formed it makes since someone would have to go in and fix it.

 

Prof Trevor Marshall
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Depends what caused the birth defect.
It seems that Vitamin D metabolism abnormalities (resulting from Th1 disease) are associated with pre-eclampsia. The VDR is also associated with the transcription of many genes, including assocuiated with Down Syndrome, which it is hard to "go in and fix." However, infections passed from mother to child can be treated. There is much still lto learn.However, which condition specifically are you concerned about?
 

Frans
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mysevenkids wrote:
if some one has a birth defect or condition from birth, how would it be possible to fix it with antibotics? it seems the problem is structure if somthing didnt form correctly, and say even if it is from bacteria cause from the start, once formed it makes since someone would have to go in and fix it.

 


Hi, this is a rather interesting question and timed perfectly, since I am at the moment corresponding with some Cystic Fibrosis patients, who also want to understand how one would explain that a disease that is said to be caused by a hereditary mutation of the cystic fibrosis transmembrane conductance regulator (CFTR) gene, could be an inflammatory disease, caused by (amongst others, CWD) bacteria.

By the way, this gene is mentioned as one of the 27,091 genes probably (partially) transcribed by the VDR, see table 4.

Paper:
http://mend.endojournals.org/cgi/content/full/19/11/2685

Table 1: (916 confirmed VDR-related genes)
http://tinyurl.com/38rtu5

Table 4: (27,000 probable VDR-related genes)
http://tinyurl.com/2wzhmb

I am very interested in any insight/answer Joyce or Trevor could provide. I have my ideas, like infectious pea-soup, but am not sure enough about them.

Sincerely, Frans

Last edited on Sun Sep 30th, 2007 14:08 by Frans

Prof Trevor Marshall
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Frans,
Tha bacteria evade the immune system by shutting down the VDR, shutting down production of most of the body's antimicrobial peptides. An unfortunate side effect of this is that the genes the VDR is supposed to assist transcription (transcription or transrepression) are also not transcribed properly by the shut-down VDR.

It is of course more complex than this. In particular, mutations can be point mutations or fold mutations. They can occur at the DNA or RNA stages. But the explanation above should be enough to carry the key concept. The bugs target the VDR, which then causes a cascade of problems.
 

Frans
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I understand, it leads one to wonder if hereditary genetic disease is even a valid name or concept

Prof Trevor Marshall
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Indeed. You might also ponder this paper, describing one of the pathways through which nuclear radiation affects the body: http://tinyurl.com/2qgmwv
 
Of course, once the D metabolism has been perturbed, the Th1 pathogens are likely to have proliferated somewhat as a result...
 

Frans
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Hmm, this reminds me of gulf war syndrome, we finally have the series House MD here on tv, and last week they had an episode about gulf war syndrome...

mysevenkids
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hi, i am actually referring to wolf parkinson white syndrome. i have that and have been thinking of fixing it and did just recently.


my symptoms were happening more frenquently.
my dr who had been hoping i would fix it, decided to order me a heart moitor for a month. i wore it all of july. two weeks after caling in my readings he caled to schedule surgery for ablation and i decided to do it. glad i did because i was on the freeway only 4 days before my procedure and i almost fainted while driving, i felt myself going in and out quickly and had to pull over.
.

i wouldnt be able to see how antibotics could fix a problem as this, or fast enough.

thanks,

joyce

 

 

Prof Trevor Marshall
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Joyce says
i wouldnt be able to see how antibiotics could fix a problem as this, or fast enough

Well, Joyce, we are not going to argue with your doctor's diagnosis, nor are we going to interfere with his care. Have you asked your doctor how long the 'fix' will keep you in remission? What is its failure rate versus time? Real hard statistics?
 

Prof Trevor Marshall
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An uninterrupted copy of the presentation is now available from Google video.
The quality is not quite as good as YouTube, as Google insists on doing their own video processing, so I was not able to use the latest technological tricks to make the slides easy-to-read.
http://video.google.com/videoplay?docid=-2390315864442431912

It can also be embedded into a webpage, and surprisingly, the slides on the smaller embedded version are a little bit clearer.

Don't forget that there is a PDF transcript, which includes clear copies of the slides, available at URL
http://www.autoimmunityresearch.org/transcripts/marshall_aaem_2006.pdf

Enjoy :)
 

paulalbert
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David Bradley embedded a link to Trevor's AAEM presentation:

http://www.sciencebase.com/science-blog/trevor-marshall-lecture/

Paul

Prof Trevor Marshall
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And now FOX news has syndicated it
http://tinyurl.com/2xtmmm

tom
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Dr. Marshall,

Recently, I met up with my older brother who has been plagued with HPV pappaloma virus on his vocal cords, a virus he has dealt with for over 10 years. He has tried a myriad of different treatments without success.  Although he had experienced some initial positive results following surgery a few years back the virus returned. Although, I have not seen this on the roster of treatable illnesses, my improved understanding of this science increases my curiosity as to the potential the MP would have on my brother’s condition.

Thanks so much,

Tom

Prof Trevor Marshall
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Tom,
The innate immune system is the body's last line of defense against pathogens. When it is perverted, the body cannot clear the pathogens which evade adaptive immunity. Suggest your brother do the D-tests, with Quest Diagnostics, and let's look at the numbers...
 

tom
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Dr,

Thanks very much. I'll get back to you

Tom

NorCalJim
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The google video doesn't seem to be working for me anymore. Anyone else having trouble with it?

NorCalJim

Prof Trevor Marshall
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I have now figured out how to put up longer video segments on YouTube, although the quality is a little lower than the original 8-segment version.

The new video is in two 35-minute segments at URLs:

http://www.youtube.com/watch?v=RpocxjKJxag
http://www.youtube.com/watch?v=ZMn-zUTTHgw

and these  are now the best URLS to use when you are sharing the video with your friends. Please update your bookmarsk.
 

Phillyguy
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Dr Trevor Marshall wrote: Depends what caused the birth defect.
It seems that Vitamin D metabolism abnormalities (resulting from Th1 disease) are associated with pre-eclampsia. The VDR is also associated with the transcription of many genes, including assocuiated with Down Syndrome, which it is hard to "go in and fix." However, infections passed from mother to child can be treated. There is much still lto learn.However, which condition specifically are you concerned about?
 


An immunological insight into the origins of pre-eclampsia (10/2010)

BACKGROUND: Pre-eclampsia is a syndrome of heterogeneous origin characterized by deficient placentation due to the inability of the cytotrophoblast to acquire an invasive phenotype and to remodel the uterine spiral arteries. One of the main problems observed early in pre-eclampsia is an altered regulation of the immune system, where the shift toward a Th2 cytokine profile observed in normal pregnancies, does not occur. In pre-eclampsia, high interferon (IFN)-gamma concentrations are present, along with transforming growth factor-beta cytokines, which retard migration of cytotrophoblasts.

METHODS: A review of the scientific literature was performed on the immunological factors associated with the origins of pre-eclampsia. The various components of the immune system that may be participating in the aberrant immune activation that pathologically affect early pregnancy events and inhibit cytotrophoblast invasion were identified.

RESULTS AND CONCLUSIONS: Cells and their signaling and regulatory molecules have been implicated in the immunological alterations found in the placental microenvironment of patients who develop pre-eclampsia. One of the main differences found in pre-eclampsia is a shift toward Th1 responses and the production of IFN-gamma. The origin of IFN-gamma is not clearly identified and could be the uterine natural killer cells, the placental dendritic cells modulating Th responses, alterations in synthesis of or response to regulatory molecules, or changes in the function of regulatory T cells in pregnancy. Aberrant immune responses promoting pre-eclampsia may also be due to an altered fetal allorecognition or to inflammatory triggers. Understanding the immunological basis for pre-eclampsia will expand knowledge regarding other adverse pregnancy outcomes.

http://www.ncbi.nlm.nih.gov/pubmed

 



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