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The Marshall Protocol Study Site > PROF. MARSHALL'S PERSPECTIVE > Prof. Marshall's Perspective > Scientists Solve Structure Key to Bacterial DNA Inheritance


Scientists Solve Structure Key to Bacterial DNA Inheritance
 Moderated by: Prof Trevor Marshall
 

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tickbite
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 Posted: Fri Jan 18th, 2008 09:31

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Segrosome structure revealed by a complex of ParR with centromere DNA.
http://tinyurl.com/3d8ryv

"When bacterial cells divide, small DNA molecules called plasmids that encode antibiotic resistance genes are distributed into the two resulting daughter cells. Biochemist Maria Schumacher of the University of Texas M.D. Anderson Cancer Center has now determined the looplike structure of a molecular complex that is key to the distribution process. The finding may lead to new strategies for defeating antibiotic resistance and offer insights on how other types of cells distribute their genetic material."
http://publications.nigms.nih.gov/biobeat/08-01-16/index.html#5 

I don't see any harm in preventing anti-biotic resistant ridden plasmid DNA segregation. My guess is that it would be a preventative medicine for those healthy population and an aid to us MP folk.

I do wonder how our immune system interacts with these plasmids and do we experience immunopathology from their destruction?

Are some plasmids good?

Lets discuss :cool:
class=storyhead




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Prof Trevor Marshall
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 Posted: Fri Jan 18th, 2008 10:56

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Greg,
That is a real nice picture. And a great topic. I have been working all night, so I will be back to join the discussion later today (after a snooze).

..Trevor..
ps: Somehow my Avatar and profile got put on Nature's Asia-Pacific webpage early this morning:) It will be up there for a week, I am told...
http://natureasia.com

tickbite
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 Posted: Fri Jan 18th, 2008 12:12

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It is a good topic. Super cool about your feature on natureasia.com. Incidentally, there is another great modelling paper that came out in nature:
The molecular architecture of the nuclear pore complex

http://www.nature.com/nature/journal/v450/n7170/abs/nature06405.html

Movie preview: http://pubs.acs.org/cen/news/85/i49/8549notw1.html

sorry the links don't route, firefox doesn't present the button for me to link.



Last edited on Fri Jan 18th, 2008 12:16 by tickbite



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Ruth Goold
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 Posted: Fri Jan 18th, 2008 12:26

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Awesome.  Hope Meg and the gang are ready for a new influx.  I'm starting to think we will soon be needing to raise funds to send the moderators on some well-deserved holidays,

Ruth



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03/02/07 Ph 1 MP; 2001: Pulmonary sarc; 01/04/07: 125 D=110pmol/L(45.8 pg/ml)| 25D=20.8 ng/ml: 04/07 19.2: 07/07 11?: 09/07 16.5: 11/07 <10.0: 01/08 <10.0: 05/08 10 ng/ml. Ca. Elocom (ears). diphenhydramine 25 mg. Adidas EE glasses outside. NoIRs
wrotek
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 Posted: Fri Jan 18th, 2008 14:37

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Beautiful work :)



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migsies
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 Posted: Fri Jan 18th, 2008 16:08

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It is good to see Dr.M getting some well deserved recognition. I suspect more is on the way now that some of your seminal thoughts on the biochemistry underlying D metabolism are in press.

What a wonderfull representation of the bacterial plasmid...It should be in an art museum! The nuclear pore is pretty neat too.


:)



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tickbite
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 Posted: Tue Apr 1st, 2008 14:12

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my first post.....:(


what characterizes microbial pea-soup? the interaction between species and then their influence on the body or the direct influence of multiple species on the body or both? can there be multiple species within one cell?



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Prof Trevor Marshall
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 Posted: Tue Apr 1st, 2008 14:28

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Both, there are definitely multiple species within the biofilm-protected metagenomic communities in the phagocyte cytoplasm. All affect each other, and affect the host.

Take a look at Amy's article on the subject, just posted at Bacteriality.com
http://bacteriality.com/news/#cult
 

tickbite
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 Posted: Tue Apr 1st, 2008 14:46

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tickbite wrote: my first post.....:(
I should have been more specific. I'm sad this thread never took off.

Anyhow, thanks for the reply. A very interesting article by Amy. I think the topic of this thread lends itself to her article topic. Sharing of genetic info is quite shocking and really hard to understand the mechanisms involved.



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