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Prof Trevor Marshall
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UPDATE:

The HD video of both presentations is now online.
The first presentation is titled "It is time to bury Koch - Infectious Disease transitions to an understanding of the Metagenome." I use the HIV and M.tuberculosis genomes to illustrate how the Th1 metagenomic microbiota interacts with the human genome to cause chronic disease:
 
http://vimeo.com/4307469

The second presentation focuses on the MP itself, and the latest observations gleaned from the MP cohort:

http://vimeo.com/4293599

-----

For those with slow computers or Internet who need a download, I have created a compact version of the videos, suitable for download. These will play using either the Mac or PC version of VLC

The MP presentation is 138 MB, and can be downloaded from
(right-click on this link to download, don't just click it or it will try to play)
http://MarshallProtocol.com/flash/Prague-MP.mp4

The main presentation is 176MB and can be downloaded from
(right-click on this link to download, don't just click it or it will try to play)
http://MarshallProtocol.com/flash/Prague-Science.mp4

..Trevor..
-------------------------------------------------------------------------------------------

Original text:
I have been asked to speak at the 'Workshop on Chlamydia Infection' on April 18th, in Prague. Two presentations are scheduled, one on the science, one on the MP, totaling 70 minutes.

The heavy-weight panel of speakers include Professor Subramaniam Sriram (of Vanderbilt, an expert on the Stratton Protocol) and Professor Tomas Rudel from Universität Würzburg, so there should be some vigorous discussion :)

I received an email from Ron (in the Netherlands) saying that he, Anne and Annamarie will be traveling to Prague for the conference, and for a get-together on Sunday. Martin (from Norway) might also be able to join us.

A conference announcement is now on the web:
http://tinyurl.com/dbwvs7

A preliminary program can be found at
http://AutoimmunityResearch.org/trash/WORKSHOP_CHLAMYDIAL_INFECTION_2009-PROGRAM.pdf

I will be setting aside Sunday for informal and follow-up meetings, so if you are in the area, please drop me an email and I will give you the contact information :)
 

Last edited on Wed Apr 29th, 2009 18:35 by Prof Trevor Marshall

Deedee
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Dr. Marshall,

I had not heard of the Stratton protocol, but was able to read some about the protocol at their website. http://www.cpnhelp.org/handbookintro

I see that the Stratton protocol implicates "tiny bacteria" that invades cells as the cause of Chlamydia and that the pathogen can invade the entire system.  He also mentioned slowly ramping antibiotics and IP, as well as a lengthy treatment period.  I have found no mention of biofilms, Vitamin D reduction or benicar (yet). 

In what way is the science behind this protocol and the Marshall protocol similar and how is it different?  How is the treatment similar or different?  

Do you anticipate that you presentation and Sriram's presentations will compliment one another?

Regards, Deedee

Martin78
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Trevor

Are you planning on recording the speaks on video and publish them at the vimeo account? (as usual?) Aremore people from the ARF coming along?

I was "this" (a small "this", far from booking a ticket right now, but I thought I would ask the other MP'ers in Norway, via our yahoo group, if they would like to join as well.

BR
Martin

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Quite awhile back (more than 10 years) i tried the Stratton protocol.  It did not induce any herxes nor did it produce any improvements.  Basically, i couldnt tell i was doing any therapy.

I did know some others who were doing this protocol, they did herx even if they didnt improve much.  Anyone have an explanation for that (that is, why some might not even herx?)     Guessing--the VDR is so dysfunctional the abx can make no difference???  If the VDR is somewhat funtional, the abx can modulate things some . . .

Prof Trevor Marshall
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Guessing--the VDR is so dysfunctional the abx can make no difference
And the winner for today is - - DOGSTER...:):)

Yes, the VDR dysfunction is progressive, and as your VDR get progressively knocked out, your body becomes less and less able to work properly.

Review Janet's six stages of Th1 disease:
http://autoimmunityresearch.org/VDR-Time-Benicar.pdf
 

Martin78
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The entrance fee for the conference is 30 EUR per person which includes lunch and refreshments, they will also assist with accommadation tips (?) Although it's easy to find good accommadation online in this area, I will opt for "Hotel Downtown" which is a new 4 star hotel 250 mtrs from the Museum (Narodni Museum = National Museum) where the session is held.

The Museum in located in Praha 1 (District 1) which is right in the center of town. April is a beatiful month to visit Praha (Prague) because there are not as many tourists there as in the summer time, after Paris, Praha is Europe's most popular tourist capital destinations.

The promised to set up a registration form online later today I will post it when it is ready.

BR

Martin

Last edited on Thu Mar 19th, 2009 22:13 by Martin78

Deedee
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I found the stuff on the meg-vitamin D supplementation on the Stratton protocol.  Yikes.   I wish I could be there.  Please share when you come back.

Martin78
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So we are three MP'ers coming down from Norway.

The registration form is now ready online:

http://www.medindex.cz/odborna-akce/workshop-chlamydiova-infekce-2009-20

Looking forward to some interesting discussions and presentations.

BR
Martin

Frans
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Trevor,

Something is not clear to me. Looking through some of the work of Adam Arkin, I am not sure if Chlamydia also uses the spo0a and other sporulation genes. Maybe none at all.

Yet Chlamydia elementary bodies have been described in detail, which seems to indicate that sporulation doés play a role in the Chlamydia species.

My question therefore is: does Chlamydia use sporulation to form these elementary bodies?

Curiously, Frans

Prof Trevor Marshall
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I haven't researched it. In Prague I will be focusing on genomes which are better elucidated than Chlamydia. Focus on the mechanisms.

Sporulation is probably not in play in the metagenomic microbiota. Probably a lot more complex interactions are in play.
 
 

Frans
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Ah, ok, but that throws a wrench into some ideas I have had about the role of sporulation in the, sometimes sudden, onset of several of these diseases.

I know sudden onset is a wrong concept, so let me call it suddenly being symptomatic.

I will give an example.

In MS, there is a form called Relapsing Remitting MS.

What I was thinking was the following.

It seems that the Relapses in RR-MS occur after some sort of stressor like an acute viral infection.

My thought was that if that happens, the brain gets perfused with blood, which might lead to sporulation turning around, bacteria active, active infection, relapse.

As soon as this stressor goes away, the bacteria that have come out of sporulation will sporulate again, since the abundantly available bloodlevels will subside again.

This then feels like 'remission', but the bacteria are simply still there, but less active in their sporulated state.

Interestingly, we have seen several diseases that move along the same patterns.

Let me give some examples:

ME:  rears its ugly head after viral infection in many cases
Same mechanism:  blood, de-sporulation, symptomatic

Sarc:  sometimes these so-called remissions: same mechanism

But the list goes goes on:

- Post Traumatic Dystrophy (Ellen has that)

but also

- Post Taumatic Stress Syndrome ...

- Post Natal depression ...

Etc.

Just thinking out loud

Best, Frans

Frans
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Another thought about this.

One thing that is common in the above diagnoses is that the tissues it starts in are tissues that are not very well perfused with blood.

Which means not very much to eat for the bacteria, which, in itself, could promote sporulation.

In posttraumatic dystrophy, the disease invariably starts at the site of tendons. Be it ankle, or wrist. Not very well perfused tissue.

Then something happens, wrist gets broken, or ankle ligaments tear. Blood rushes in, carrying food for the bacteria and wham, symptomatic.

RSI might be another example. Loads of repetitions, more blood, de-sporulation, etc etc.

This might also be one of the factors why exercise sometimes leads to more herx. Or why bathing in hot water does so. Higher temperature, perfusion, etc.

It sounded good when I thought it out  :D

Frans

Prof Trevor Marshall
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Frans,
In Prague I will be trying to explain why the problem of the human metagenomic microbiota is imponderable.

So don't get too downcast over not being able to describe it exactly :) There are just too many things going on at once for the system to be deterministic. It is stochastic, not deterministic :)
 

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How was it ?

Best, Frans

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Hi Frans!

It was very interesting and awsome to meet Dr.Marshall in person! :dude:

About the content of the workshop I think Dr.Marshall can better explain that part.

Prague is a beautiful city, we've had great weather and met very nice people there.:cool:

 

Annemarie

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Indeed, really nice people! I put some pictures here.

Prof Trevor Marshall
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The first video, the presentation which explains why the MP has not much to do with Antibiotics :) is now up online at URL:

http://vimeo.com/4293599

Ron has offered to do a written transcript, but it is a big job. Please contact Ron if you can help him do some of the text :)

The main presentation will be online tomorrow... Even more transcribing will be necessary then - it runs about 50 minutes, including questions.
 

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Trevor,

In this presentation you mention a study (Cochrane and National cancer institute?) that went through 500 papers on vit. D where the conclusions did not fit the data.

Can you give us the pubmedID of that paper ?

Best, Frans

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AWESOME...AWESOME...AWESOME Presentation!!!:cool:
I felt like I was there when watching the VIMEO.
It was easy to understand everything....
I am so blessed and excited that Little Man Jake and I are recovering our health.

WOW! I will go to work today renewed and excited in body and spirit:D
(I will go to work today.....this in itself is amazing;))

Thank You Dr. Marshall:)

WOW!:P

P.S. who was that guy standing in front of the camera blocking you off and on??? MOVE PLEASE:shock:


Prof Trevor Marshall
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Frans,
Joyce just wrote an excellent paper for Annals of the NY Academy of Sciences which reviewed all the relevant literature. We should be able to put a preprint online soon, but meantime, I have emailed you a confidential copy.
 

Prof Trevor Marshall
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who was that guy standing in front of the camera blocking you off and on?
That was our host, conference organizer Dr. Radek Klubal :):)

Luckily, I had the camera up high, so only his head was blocking. I didn't notice he was in the way, or I might have moved my own position a little :):)
 

Prof Trevor Marshall
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The first of my two presentations is now online. This presentation is titled "It is time to bury Koch - Infectious Disease transitions to an understanding of the Metagenome." I use the HIV and M.tuberculosis genomes to illustrate how the Th1 metagenomic microbiota interacts with the human genome to cause chronic disease.
 
http://vimeo.com/4307469
 

jcwat101
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This article http://www.townsendletter.com/Jan2009/vitaminD0109.htm also covers some of the same material that Trevor referred Frans to (and some additional literature), though of course the Annals, peer-reviewed one will be better to refer to when it comes out .  But, you can see some of the cancer and other literature covered in this one (also on vitamin D and colds and flu).

Joyce Waterhouse

Last edited on Fri Apr 24th, 2009 08:00 by jcwat101

paulalbert
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When ready, the transcripts can go here:
http://mpkb.mp-dev.com/doku.php/home:publications:marshall_chlamydia2_2009
http://mpkb.mp-dev.com/doku.php/home:publications:marshall_chlamydia1_2009

Paul

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Trevor,

I have very slow broadband and the second presentation, on the MP itself, took well over an hour to buffer (but was worth waiting for :)).  Is there any way I can download it to my computer to refer to again?  I have this problem with most of the MP videos, especially with Vimeo.

Julia

Martin78
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Julia, if you download Realplayer (for free), you will be given the option to download the video from vimeo directly to your harddrive, this way it will not need to buffer.

At least that is what I have been doing when faced with this problem.

BR
Martin

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Julia, did you switch the HD button off? It is a button towards the middle right of the display screen, and should say "HD is off" when you have a limited bandwidth connection.
 

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Trevor, the HD is off by default and I leave it that way.

Martin, thank you, I think you may have solved my problem - my version of RealPlayer was so old it wasn't functioning and I'd forgotten about it.  Now I've installed the new one it seems to be busy downloading properly :)

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Dr Marshall,

Totally enjoyed your presentation.:)

Forgive me if I have a hearing problem but half way through your presentation you referrred to 3 abx's - Clindy, Mino and the R abx. Is this a new bacteriostatic abx or were you referring to Zith.

regards,

Ralph

Prof Trevor Marshall
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Rifampin is an antibiotic we do not use. I don't know if it will work against the Th1 pathogens, but its side effects are pretty severe. We have much better antibiotics available to us :)

The relevant thing in my presentation was that all three antibiotics are known PXR receptor agonists, and therefore behave differently in-vivo and in-vitro :)

All three antibiotics were originally isolated from pathogens... Maybe the body remembers more about antibiotics than we do...
 
 

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Thank you so much for that. 

Seeing the HIV infected cell directly infect another cell without the need for blood makes it very clear why Benicar is needed.  At least to me!!!  I may not have understood much of the presentation, but what I did understand expanded my knowledge of the MP.  Also, although I could not make sense of much of the presentation, I could tell it was a powerful one, and I can only hope that it makes sense to most of the people who attend these conferences and will help doctors understand why we do what we do on the Marshall protocol (that much I got).

Looking forward to the other presentation.

Thanks again, Claire

Prof Trevor Marshall
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Julia,
I send the videos up to Vimeo in a special format called H.264, which very few computers can decode. Additionally, the files are about 300 megabytes in size. So there is really little point in encouraging people to download the files directly. Best to watch them, or use some of the capture software which is available these days :)
 

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Trevor,

Excellent work at the workshop. Do you feel that any of the other participants had an "Ah Ha!" moment? Did you walk away with anything to help fill in some of the pieces of the puzzle?

How can I get a copy of the gene disease map you displayed in your presentation? I searched online and found versions of it but not one as complete as yours.

Regards,

Lee

Prof Trevor Marshall
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Lee,
Amy cites the article containing that map in our latest paper:

http://AutoimmunityResearch.org/transcripts/AR-Proal-Metagenome.pdf
 
:)
 

Frans
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Lee,

The paper is called: The Human Disease Network  (PMID 17502601)

You can find it on pubmed.com

Search for: 17502601

Hope this helps, Frans

Last edited on Sat Apr 25th, 2009 08:44 by Frans

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Trevor,

That explains why it took 2hrs 20m to download and now refuses to play!  That means I can't watch it or refer to it again, without waiting for the endless buffering, and while it's buffering, everything else slows down or won't work :(  Isn't there some way you can make videos available to those of us with frustratingly slow connections?  What is capture software?

Julia

Ron
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Julia,

What a bummer that the video won't play. Can you tell us the format of the file you downloaded? Does it have a .flv or a .mp4 extension?

I always use K-Lite and it comes with Media Player Classic. Works very well and I can play virtually all formats (including Real Media, I hate that commercial software).

Ron

Last edited on Sat Apr 25th, 2009 11:52 by Ron

Julia
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Ron,

Realplayer says it's MP4, 248MB.  Is K-Lite a decoding thing?  I have Windows Media Player, which plays music, and BBC iPlayer for films, but maybe that's only for BBC films, I wouldn't know :? 

Ron
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Yes, K-Lite is a codec pack.

But even better is VLC Media Player as that one is less likely to mess up your current installation. It even can play the MP4-stream directly (File - Open Network Stream).

VLC will definitely play your downloaded MP4 file.

eClaire
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Am I being paranoid or what? 

After watching the video, given the accumulation of microbiota over time, I could not see the value of ever eating foods naturally high in Vitamin D in moderation--that is, after I am well.  I could see occasional consumption (perhaps where it cannot be avoided), but not an active decision to consume a food high in vitamin D on a regular basis.  So while I don't see myself being overly strict (e.g., never eating out or forcing people who have invited me to dinner to comply with my diet), I do see maintaining an awareness that these foods (in addition to added D) are not foods that I want to eat. 

Am I going too far?  Is there any value in these foods that I am missing that would outweigh their potential negative impact?

Thanks, Claire

Prof Trevor Marshall
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Isn't there some way you can make videos available to those of us with frustratingly slow connections?
I did not encode the video you downloaded from Vimeo. It was encoded by Vimeo's software for playing in Adobe's Flash player, which integrates itself with your browser when you click on the link. I have no idea what Real Player did when capturing it, I do not use that software. Nor did I choose the parameters which Vimeo uses for HD.

The version I encoded to send to Vimeo will play in VLC, if you have a sufficiently fast computer, which means at least a recent Pentium 4, preferably a Core-2 Duo CPU. Some Atom CPUs, in low-cost netbooks, are fast enough to run VLC and Adobe Flash.
 
DVDs are not really an option, either, It takes a huge effort for Liz to mail out DVDs, and we periodically even have problems with people whose equipment is having trouble viewing them. In the last two days over one hundred people have viewed the Prague videos, and over 1000 have viewed the China keynote since December. Distribution via Vimeo seems effective. I am sorry if it is creating headaches for you :X
 
 

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I could not see the value of ever eating foods naturally high in Vitamin D in moderation--that is, after I am well
Claire,
As long as the 25-D in the bloodstream dose not exceed the level at which it starts to affect the cells (<12ng/ml is certainly safe), healthy people can eat foods with Vitamin D without any real trouble. But you are correct, there is really no reason to eat foods high in Vitamin D, there are always alternatives.
 

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I have Pentium 4, but my phone line is only capable of around 300-400 Kbps due to my position in relation to the telephone exchange :X

Prof Trevor Marshall
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To help Julia, and the others who need a download, I have created a compact version of the videos, suitable for download. These will play using either the Mac or PC version of VLC

The MP presentation is 138 MB, and can be downloaded from
(right-click on this link to download, don't just click it or it will try to play)
http://MarshallProtocol.com/flash/Prague-MP.mp4

The main presentation is 176MB and can be downloaded from
(right-click on this link to download, don't just click it or it will try to play)
http://MarshallProtocol.com/flash/Prague-Science.mp4

:)
 
 

Last edited on Sat Apr 25th, 2009 19:05 by Prof Trevor Marshall

JohnMcC
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Hello Dr Marshall,
I really enjoyed the presentations and while much of the material is becoming familiar, some of the more in depth stuff is a challenge to get my head around...hopefully as I get my mind back..:cool:

I did have a question regarding part of the conversation and the usage of Clindy and Zith - with the unique challenges presented by both of these drugs to MP patients did I understand a potential shift in use, perhaps in a way to allow for more controlled IP - or did I misunderstand.

Thanks
John

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John,
You will also detect a subtle shift in emphasis if you look carefully at the new Phase One guidance which is now online:

http://AutoimmunityResearch.org/phase1.pdf

As we move towards mainstream, and as West China Hospital gets up and running, I have had the chance to look back over the last seven years and take stock of what we observed from the vantage point of our better understanding of the science :):) The protocol guidance is necessarily going to have to change so that physicians do not feel so overwhelmed when they encounter problems :):)
 

eClaire
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Not to mention those of us who start the protocol (speaking from the experience of someone who ran into trouble under the previous Phase One guidelines)!!! 

I think the new Phase 1 is great and I am glad to have been a part of this study.  The new recommendations would have been extremely helpful to me when I started the MP back then (with 20/20 hindsight of course), and I am so incredibly glad they are in place for people who are beginning the protocol now. 

So...great job; the new document will benefit everyone.

Claire

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Thanks Dr Marshall,
It is always good policy to review & improve...I really take my hat off to the early adopters, with the steps forward that you have made - it makes it easier for the next gen adopters.

I did breeze through the new Phase I - I need to re-read (and pay attention) and look forward to the new  II & III docs.:cool:

I also wonder (rhetorical) what will become of the process once you have 10's of thousands and more MPer's and more research data....the story continues....can there be another quantum leap in process, changes in IP, time lines....The base is complete and solid for AI disease and it's treatment - where does the research continue from here?

I need to get some more clindy....I'm thinking too much...:cool:

Regards
John

Karl B
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I just read the paper submitted by Amy:

http://AutoimmunityResearch.org/transcripts/AR-Proal-Metagenome.pdf

where she states that lactobacillus and bifidobacteria affects the ACE gene, that in turn is "associated" with sarcoidosis.

I my case I got the first signs that I can remember of sarcoidosis when I was 20 years old. Around 10 years ago at age 36, the symptoms got worse. Eye and lung affection started to cause problems.

Roughly at the same time I had started to eat both foodstuffs with probiotic flora and regularly also probiotic pills containing lactobacillus and sometimes bifidobacteria.
My stomach reacted positively to the probiotics.

Can it be that my sarc condition got worse because of the probiotics?

Last edited on Sun Apr 26th, 2009 20:38 by Karl B

Prof Trevor Marshall
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Karl,
It is probable that your sarcoidosis started much earlier than you exhibited symptoms, but who knows? We are all at a learning-stage right now :)
 

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Just a reminder that Ron is coordinating the work to get a transcript completed. If you can help, please PM him directly.
 

Ron
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Almost finished transcribing the second presentation.

If someone is willing to start with the first (science) presentation then please go ahead. It's a huge job so working on it with several persons would be best.

Consider it a good way to get up to date with the latest cutting edge MP science! :)

Ron

Joyful
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Good work Ron!

I really want to help out... just one good night of insomnia... and ...who knows how much I can get through. :cool:

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  Ok... 10% done.
At 5min,10seconds... how to spell "staph-or-eous"?

Edit: never mind... Google is now my spell-checker...

  50% done....

Last edited on Wed Apr 29th, 2009 04:29 by Joyful

Knochen
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Dr. Marshall,

I have watched the new videos a couple of times and have really enjoyed them.  Great work.  I'm also seeing some changes in the recommendations on the forums based on these presentations.  Obviously, reinstating a competent VDR and innate immune system is the key, and that requires Benicar.  But you also make a brief comment at about 4 minutes in the MP presentation that needs some clarification.

"We have to use sub-inhibitory, that's very low doses, of bacteriostatic antibiotics in order to address the biofilms..."

What this is saying to me is that, although the MP is not an antibiotic therapy per se, they are still a critical component in the overall treatment plan.  Is this correct, or can benicar alone do the job right from day 1?  If benicar alone, how long might it take in the case of someone who has significant, long standing illness?  Does benicar alone sufficiently address well established biofilms?

Or are you saying that there must be an initial assault on the biofilms using antibiotics to clear the way for the reactivated innate immune system to do its work effectively? Stage 5 would be obvious for benicar alone, but what about earlier? 

My concern is that I've been seeing posted recommendations that benicar alone can do the job, and that is a big change in the way things have been presented before.  I wanted to be sure that people weren't engaged in "selective listening" to the presentation, hoping to find an easy way to "do the MP", while really not adressing all the issues.  If you could give us your thoughts, it would be very much appreciated.  Thanks.


Prof Trevor Marshall
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What this is saying to me is that, although the MP is not an antibiotic therapy per se, they are still a critical component in the overall treatment plan.  Is this correct, or can benicar alone do the job right from day 1?

It depends on how ill a patient is to begin with, and the exact nature of their metagenome. Healthy people can take any quantity of Benicar and antibiotics, and never experience any immunopathology.

A few people get very severe immunopathology from day one of taking Benicar. They will not need antibiotics until their immunopathology fades, and their immune system needs help to identify and target any remaining pathogens.

However, some who are ill can start Benicar get palliation, no significant initial immunopathology, and need antibiotics to start the killing process.

At some point everybody will reach stage 5 of the disease process:

http://autoimmunityresearch.org/VDR-Time-Benicar.pdf
http://autoimmunityresearch.org/stage5.pdf

when their immune system is doing the job well enough by itself. Benicar primarily provides organ protection and palliation from this point to recovery.

Eventually everybody recovers to the point where the antibiotics have no effect any more, you can take them like candy. Those  who were healthy to start with are at this point from day one. Those who were very ill will take years of immunopathology to get to this point. It all depends on how sick the patient was, and the nature of their metagenome (some species are easier for the body to target than others).
 
I hope this helps :) You might like to review our new Phase 1 guidance document:

http://AutoimmunityResearch.org/phase1.pdf
 
 

ChristineL
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Dr. Marshall,

Is there ever a circumstance where a patient would only take Benicar and never need to add the antibiotics.  For example, a spouse of someone with TH1?

Thanks!

Prof Trevor Marshall
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It is always a good idea to add some antibiotics from time to time, just to make sure they have no effect, and that the immune system is doing the job well enough :)
 

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Here are the transcripts (you can click on and see the vimeo video at these links also) . The second one needs further transcription, I think:
http://mpkb.mp-dev.com/doku.php/home:publications:marshall_chlamydia1_2009
http://mpkb.mp-dev.com/doku.php/home:publications:marshall_chlamydia2_2009

Both could be proofread.

By the way, substances like olmesartan are not capitalized. Brand names like Benicar are. Clindamycin and azithromycin are both substance names.

Paul

EDIT: credit for transcription goes to Joyful and Ron

Prof Trevor Marshall
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Thanks Paul, I am proof-reading them now
 

Prof Trevor Marshall
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I have proof-read the Science presentation and the MP presentation+MP questions. Is anybody working on transcribing the Q&A session for the Science presentation?
 

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I think this is wide open. Whoever does it, I'll check the spelling and put it up for you.

Paul

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Oh! Sorry.

I transcribed the first question and the HIV video slide last night but didn't post them until just now... the questions are really hard to hear, but I'll finish up here with the last one shortly.


Edited to add:

The questions are transcribed as best as I could pick out the meaning between the background noise and interesting Prague accent.

Your answers, Dr. Marshall, were far easier to make out as I have become quite familiar with your special dialect of Southern (California) Australian! ;)


Last edited on Fri May 1st, 2009 02:23 by Joyful

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I like the presentation very much.

Especially enjoyed that HIV moves from one cell to another without entering space between cells- the movie in the end of presentation is great. I wonder, would making cells separated somehow , less agglutinated helped to slow down infection progression and improve treatment ?

Is there a good paper to read about how HIV uses VDR machinery for it's benefits ? Would love to read something about it. 

Last edited on Fri May 1st, 2009 04:28 by wrotek

paulalbert
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Have a look at the KB's work in progress article on HIV/AIDS.

wrotek
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thx

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Thanks Joyful, Thanks Ron, Paul, and everyone. I have proof-read the Q&A session and have sent the transcripts and slides to Janet so that she can create the all-important hard-copy transcript to print for those Doctors who never touch a web browser :):)

Thanks, everybody. These two presentations, despite my bumbling around with words, will serve to let people know how far along we are in understanding the importance of the Th1 metagenomic microbiota to mankind :):)

Later this month Amy will be giving a presentation on "Antibodies and Infection in the Era of the Metagenome" at the  Intl Congress of Antibodies in Beijing. I will be accompanying her at the conference, I will be filming her talk, and will also traveling to West China Hospital to complete our planning there. Amy's presentation is something for us all to look forward to :):)
 

Joyful
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Dr. Marshall,

I thought your presentations were very good.

Due to our international audience, having you say the same thing a couple of different ways should be helpful to overcome the language barriers. That's how I perceived your manner of speech. (Not as bumbling.) But I know how awful it can feel to review your own presentations after the fact... always room for improvement.

However, from this somewhat 'critical' reviewer, I came away with a great respect for your ability to pull complex concepts together to "tell the story" and saw you as being very effective at bringing those concepts within reach of your audience. :cool:

eClaire
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I will ditto Joyful in that.  I think your ability to story tale the science and the MP is getting better and better, and I think this is an essential skill for catching the imagination of the intended audience (even doctors and researchers whom one would think this might not be necessary)!! 

Claire

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Trevor, I've only listened to the Prague videos for the first time, this evening. I wonder how well your Infectious Disease/Metagenome presentation was taken? I mean, you said in so many words at a Clamydial Conference that they are wasting their time focusing on Clamydia co-infections rather than with intraphagocytic pathogens. Curious...

Very interesting, indeed.

Rico

Last edited on Thu May 7th, 2009 17:05 by Rico

Prof Trevor Marshall
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At least part of the audience were suffering from Chlamydial infection, and looking for answers. I also felt that the physicians were looking for answers too. Remember they also invited Chuck Stratton (the Stratton Protocol) (Prof Sririam actually made the trip).

Why would they invite the MP and the SP if they weren't looking for answers?

I will be watching for signs of follow-up over the next few months :)
 

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OK, the presentations are ready to look over and I sent them to Dr Marshall.

Prof Trevor Marshall
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Janet's transcripts are suitable for printing and giving to Doc. You can find them at:

http://AutoimmunityResearch.org/prague_2009/science.pdf

http://AutoimmunityResearch.org/prague_2009/MP.pdf
 
Thanks for doing these transcripts, Janet, Ron and all the others who helped :):)

eClaire
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   JANET!!!

Limburg
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Beautiful, Janet! :D

Last edited on Sun May 24th, 2009 12:15 by Limburg

Grateful Survivor
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This is so exciting.  These two presentations (thank you Janet for the great transcriptions) are the best summaries I've seen yet.  I will be printing both for docs and for seriously interested friends.   --Dody 

Caitiegirl
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Beautiful job everyone. I love the clinical aspects that are being addressed in the conferences this year. I can finally see the MP as a working protocol for mainstream medicine. I am working up packets to give not only Caitie's doc but to other doctors we see throughout our journey. Well done!  :D
Mindy

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Trevor,

You mention the study where M. Tubercolosis downregulated the VDR 3.3 fold.

I was wondering if we know which mechanism they utilise to do so ? Is it capnine ?

Best, Frans

Prof Trevor Marshall
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Frans, the result is described in this study, although the mechanism is still unknown:

"Synergistic action of vitamin D and retinoic acid restricts invasion of macrophages by pathogenic mycobacteria"
http://www.ncbi.nlm.nih.gov/pubmed/18327422

I might add that the VDR seems to have some similar functions to PXR, FXR and the other newly discovered nuclear receptors, and I would be surprised if VDR down-regulation is the only effect present.

Capnine is a ligand, while the actual production of VDR itself is what was found to be down-regulated in the earlier M.tb study I cited in Prague. They used a micro-array to make their measurements. It is generally believed that the VDR itself is primarily transcribed by the newly-discovered Estrogen-receptor-beta
 



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