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The Oral Fungal Microbiome
 Moderated by: Prof Trevor Marshall

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Prof Trevor Marshall
Foundation Staff

Joined: Fri Jul 9th, 2004
Location: Thousand Oaks, California USA
Posts: 16174
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 Posted: Mon Mar 8th, 2010 05:57



Interesting that there were unculturable fungi identified :)

Also interesting that the average pyro-sequencing read-length was 248 base-pairs, quite long sample lengths. That should give good accuracy in identification of the pathogens :)

The easy-read version is at:



Joined: Sat Aug 1st, 2009
Location: San Francisco, California USA
Posts: 885
Status:  Offline
 Posted: Mon Mar 8th, 2010 12:42


Thanks for posting this Dr Marshall... very interesting indeed!

This all just points out how important it is to have a fully functioning immune system to keep the plethora of these microbes under control.  It appears that many of the organisms that can make us very ill.. are present in and on our bodies all the time ... even in healthy individuals.  And it is those who have a compromised immune system that get sick! 

All this research backs up the important work you have done in identifying the importance of the properly functioning VDR for getting ... and staying healthy. 

PLS/ALS, speech difficulty, dizziness, leg weakness, overly emotional, Ph1Aug2609,11/2012 25D-12, 11/11: 25D-10, 04/11: 25D-11, 07/10: 25D-13, 05/10: 25D-15, 11/09: 25D-20, 9/09: 25D-27, 7/09: 25D-38, 1,25D-46, Mod Ph2Oct09, 100mg Mino

Joined: Sun Sep 2nd, 2007
Location: Oxford, Georgia USA
Posts: 51
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 Posted: Thu Mar 11th, 2010 11:22


I found another article of interest related to this topic, from "Nature" March 2010:

"A human gut microbial gene catalogue established by metagenomic sequencing"

To understand the impact of gut microbes on human health and well-being it is crucial to assess their genetic potential. Here we describe the Illumina-based metagenomic sequencing, assembly and characterization of 3.3 million non-redundant microbial genes, derived from 576.7 gigabases of sequence, from faecal samples of 124 European individuals. The gene set, ~150 times larger than the human gene complement, contains an overwhelming majority of the prevalent (more frequent) microbial genes of the cohort and probably includes a large proportion of the prevalent human intestinal microbial genes. The genes are largely shared among individuals of the cohort. Over 99% of the genes are bacterial, indicating that the entire cohort harbours between 1,000 and 1,150 prevalent bacterial species and each individual at least 160 such species, which are also largely shared. We define and describe the minimal gut metagenome and the minimal gut bacterial genome in terms of functions present in all individuals and most bacteria, respectively.

Persistent urinary tract infection, prostatitis. MP start 2008. Faraday cage 2/18.

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