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jrfoutin
Research Team
| Joined: | Mon Aug 8th, 2005 |
| Location: | Utah USA |
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Posted: Tue Aug 21st, 2018 18:20 |
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Agreed.
Dr Marshall's May 2018 presentation is chock full of clarity.
https://www.youtube.com/watch?v=60-VAun2R6Q
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Sarcoidosis 125D61, MP10/05 ModP2 12/05 Ph2 6/06 Ph3 10/06, NoIRs limited outings covered, 2/08 25D6.2, 10/08 25D6.9, 7/20 25D<7 1,25D 23.8
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Dmitry
Support Team
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Posted: Wed Aug 22nd, 2018 16:28 |
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There are even more studies in the recent years defining extracellular D25 and D1.25 as a powerful anti-inflammatory substances with a negative correlations between TLR2/TLR4 expression, pro-inflammatory cytokines and the levels of D25/D1.25.
As an additional material for:
https://mpkb.org/home/othertreatments/sunshine / Sunlight can be immunosuppressive
Regulation of cytokine responses by seasonality of vitamin D status in healthy individuals
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074219/
Circulating concentrations of 25(OH)D3 and 1,25(OH)2D3 were higher during summer (P < 0·05) and a down-regulation of TLR-4-mediated IL-1β, IL-6, TNF-α, interferon (IFN)-γ and IL-10 production in summer was observed compared to winter (P < 0·05). The variation in cytokine response upon TLR-2 (Pam3Cys) stimulation was moderate throughout the four seasons. The repressed cytokine production during the summer months could be explained partly by the reduced cell-membrane expression of TLRs. Physiological variation in vitamin D3 status through the four seasons of the year can lead to alteration in the innate immune responses. Elevated vitamin D3 level in vivo is associated with down-regulation of cytokine response through diminished surface expression of pattern recognition receptors.
Variation in serum vitamin D3 levels throughout the four seasons of the year.
Variation in cytokine responses to lipopolysaccharide (LPS) stimulation during the four seasons of the year.
Expression of (a) Toll-like receptor (TLR)-2 and (b) TLR-4 on the cell membrane of monocytes.
Peripheral blood mononuclear cells (PBMC) were isolated from 15 healthy volunteers during each season.
In conclusion, we have demonstrated for the first time that variations in innate immune response exist throughout the four seasons of the year. In summer, elevated serum vitamin D3 levels are associated with an attenuated cytokine-producing capacity attributable to a suppressed expression of TLR-2 and TLR-4.
TLR2 and TLR4 mediated host immune responses in major infectious diseases: a review
https://www.sciencedirect.com/science/article/pii/S141386701500224X
Toll-like receptors (TLRs), especially the surface ones viz. TLR2 and TLR4 have gained immense importance due to their extreme ability of identifying distinct molecular patterns from invading pathogens. These pattern recognition receptors (PRRs) not only act as innate sensor but also shape and bridge innate and adaptive immune responses. In addition, they also play a pivotal role in regulating the balance between Th1 and Th2 type of response essential for the survivability of the host. In this work, major achievements rather findings made on the typical signalling and immunopathological attributes of TLR2 and TLR4 mediated host response against the major infectious diseases have been reviewed. Infectious diseases like tuberculosis, trypanosomiasis, malaria, and filariasis are still posing myriad threat to mankind. Furthermore, increasing resistance of the causative organisms against available therapeutics is also an emerging problem. Thus, stimulation of host immune response with TLR2 and TLR4 agonist can be the option of choice to treat such diseases in future.
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Recognition of the array of pathogens though TLRs:
TLR4: Gram-negative bacteria, Pseudomonas aeruginosa, RSV, MMTV, Saccharomyces cerevisiae, Candida albicans, Cryptococcus neoformans, Aspergillus fumigatus, Trypanosoma cruzi, Plasmodium falciprum, Toxoplasma gondii, Leishmania major, Entamoeba histolytica, Filarial nematode, Acanthocheilonema Viteae, Taenia crassiceps
TLR2: Gram-positive bacteria, Streptococcus B, Staphylococcus aureus, Trepanema maltophilum, Wolbachia, Borrelia burgdorferi, Staphylococcus epidermidis, Mycobacterium tuberculosis, Pseudomonas aeruginosa, Measles, Herpes, Saccharomyces cerevisiae, Candida albicans, Trypanosoma cruzi, Plasmodium falciprum, Toxoplasma gondii, Leishmania donovani, Leishmania major, Leishmana sp., Leishmania mexicana, Entamoeba histolytica, Ascaris lumbricoides, Schistosoma mansoni, Schistosoma japonicum, Taenia soliumLast edited on Wed Aug 22nd, 2018 17:41 by Dmitry
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MP Sep16 25D17 125D21 | Sep17 25D22 125D27 | May18 25D10 125D29 | heavy brain fog, anxiety, fatigue, depression
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Sallie Q
Member*
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Posted: Wed Aug 22nd, 2018 23:00 |
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In conclusion, we have demonstrated for the first time that variations in innate immune response exist throughout the four seasons of the year. In summer, elevated serum vitamin D3 levels are associated with an attenuated cytokine-producing capacity attributable to a suppressed expression of TLR-2 and TLR-4.
Luckily, the immune suppression to be expected in summer would be somewhat offset by reduced exposure to microbial infested air indoors IMHO
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VideoMP'08-'11(now@3x20mgOLM)Dx Depressn'70,node&brCancer'90,BCC'05,Sjgren08|SxCFS,RA,stroke,ASD,reflx 25D=9ng/ml_Nov'17Info
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Dmitry
Support Team
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Posted: Wed Aug 22nd, 2018 23:14 |
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As we know, TLR9 is also suppressed(by D3)
https://www.ncbi.nlm.nih.gov/pubmed/20435648
TLR9 and TLR7 are used to recognize bb:
Recognition of Borrelia burgdorferi, the Lyme disease spirochete, by TLR7 and TLR9 induces a type I IFN response by human immune cells.
https://www.ncbi.nlm.nih.gov/pubmed/19794067
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MP Sep16 25D17 125D21 | Sep17 25D22 125D27 | May18 25D10 125D29 | heavy brain fog, anxiety, fatigue, depression
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be-well
Member
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Posted: Tue Jun 4th, 2019 21:04 |
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'Vitamin D could help cancer patients live longer | MSUToday ... [url=https://msutoday.msu.edu/news/.../vitamin-d-could-help-cancer-patients-live-longer/']https://msutoday.msu.edu/news/.../vitamin-d-could-help-cancer-patients-live-longer/'[/url]
This article was on the front page of The Times here in UK today and three other major UK newspapers but not on their front page. It will no doubt cause a surge in people with chronic diseases wanting to take the vitamin D, or thinking it may be a good preventative measure. Here is the link to the original paper included with the newspaper article:
https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.1534)Last edited on Tue Jun 4th, 2019 21:07 by be-well
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mcs,chronic fatigue,hiatus hernia,grains intolerance,tinnitus,photosensitivity,lesion in splenium of corpus callosum
25-D-3.3,-1,25D-70,Dec 2014.25-D-18, 1,25D,45.Sept 2019.
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Rico
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| Joined: | Tue May 30th, 2006 |
| Location: | Canada |
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Posted: Sat Jun 8th, 2019 17:53 |
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Vitamin D fails to prevent diabetes type II in large study
https://www.reuters.com/article/us-health-diabetes-vitamin-d-idUSKCN1T82AS
https://www.nejm.org/doi/full/10.1056/NEJMoa1900906
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No diagnosis/some symptoms (more than I knew); wife with Sarc on MP; Olm 40mg q4-6h | 25D=22 (May 2014) | 25D=27 (Nov 2014)
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davidmac
Support Team*
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Posted: Sun Jun 30th, 2019 15:28 |
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| STUDY: FISH OIL DOES NOTHING TO BOOST BRAIN HEALTH...
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MP Oct'10 (Break: June '16 - Aug '16) | CFS '87| Brain-fog, IBS, depression, inflammation, nerve pain| last 25D= 4 ng/ml Jan '16. Progress Thread
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Rico
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Posted: Sun Jul 7th, 2019 22:11 |
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Great. Higher content of Vitamin D in eggs ...
https://www.sciencedaily.com/releases/2019/06/190624111502.htm
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No diagnosis/some symptoms (more than I knew); wife with Sarc on MP; Olm 40mg q4-6h | 25D=22 (May 2014) | 25D=27 (Nov 2014)
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Rico
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Posted: Sat Nov 9th, 2019 13:08 |
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Vit D Supplements Flop Again for Bone Health
https://www.medpagetoday.com/meetingcoverage/asbmr/82341
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No diagnosis/some symptoms (more than I knew); wife with Sarc on MP; Olm 40mg q4-6h | 25D=22 (May 2014) | 25D=27 (Nov 2014)
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scooker48
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Posted: Thu Nov 12th, 2020 15:58 |
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https://medicaldialogues.in/medicine/news/no-health-benefits-of-vitamin-d3-omega-3s-and-exercise-in-elderly-jama-71337
No Health Benefits Of Vitamin D3, Omega-3s And Exercise In Elderly: JAMA
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D25, Total: 12 measured 11/3/15 Started MP=01/04/05 Diagnosis: Sarc 12/04; "cat scratch disease" or necrotizing graunulomas 10/88; Raynaud's (diagnosed 1980?)
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scooker48
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Posted: Tue Dec 1st, 2020 18:38 |
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https://www.genengnews.com/news/active-vitamin-d-levels-linked-to-gut-microbiome/
Vitamin D metabolites and the gut microbiome in older men
Another nail in the coffin!
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D25, Total: 12 measured 11/3/15 Started MP=01/04/05 Diagnosis: Sarc 12/04; "cat scratch disease" or necrotizing graunulomas 10/88; Raynaud's (diagnosed 1980?)
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scooker48
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Posted: Wed Dec 16th, 2020 17:10 |
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https://www.wjgnet.com/1007-9327/full/v26/i46/7352.htm
World J Gastroenterol. Dec 14, 2020; 26(46): 7352-7366
Colonic vitamin D receptor expression is inversely associated with disease activity and jumonji domain-containing 3 in active ulcerative colitis
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D25, Total: 12 measured 11/3/15 Started MP=01/04/05 Diagnosis: Sarc 12/04; "cat scratch disease" or necrotizing graunulomas 10/88; Raynaud's (diagnosed 1980?)
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scooker48
Member*
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Posted: Fri Dec 18th, 2020 20:09 |
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https://www.nytimes.com/2020/12/17/opinion/federal-executions-trump-alfred-bourgeois.html?searchResultPosition=1
The above link is to a story about capital punishment; the author witnessed the execution of Alfred Bourgeois on Friday, December 11, 2020. It is a grim story, and I do not recommend anyone read it; the link is provided only as a courtesy.
I do not judge anyone involved in such a crime, although it is a highly repulsive act. I do, however, posit that Alfred Bourgeois was not well. Knowing what I now know from reading this blog. What never fails to amaze me is what he requested for his "last meal": seafood-stuffed mushrooms, a platter of fried shrimp, shrimp Alfredo pasta, six buttered biscuits and cheesecake. Full of "vitamin D" when he died. Sigh. Sherry
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D25, Total: 12 measured 11/3/15 Started MP=01/04/05 Diagnosis: Sarc 12/04; "cat scratch disease" or necrotizing graunulomas 10/88; Raynaud's (diagnosed 1980?)
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scooker48
Member*
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Posted: Sat Jan 2nd, 2021 22:29 |
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https://pediatrics.aappublications.org/content/147/1/e20200815
Vitamin D for Growth and Rickets in Stunted Children: A Randomized Trial
CONCLUSIONS: Except in those with higher calcium intake, vitamin D supplementation had no effect on rickets or growth.
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D25, Total: 12 measured 11/3/15 Started MP=01/04/05 Diagnosis: Sarc 12/04; "cat scratch disease" or necrotizing graunulomas 10/88; Raynaud's (diagnosed 1980?)
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Markt9452
Support Team
| Joined: | Fri Oct 26th, 2007 |
| Location: | Ontario Canada |
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Posted: Wed Feb 24th, 2021 01:07 |
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MP Feb08 - light sensitivity, fatigue, confusion, muscle twitching, memory loss, dyslexia, skin lesions, sore feet, electrical sensations, vertigo, tinnitus, 125D20 D25<10 2008.Ivermectin topical 1 gram 7-10 days
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Claudia
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| Joined: | Fri Sep 23rd, 2005 |
| Location: | Cooroy, Australia |
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Posted: Wed Feb 24th, 2021 08:04 |
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Shlitz! Who knew it was a "health food"?
LOL
Not what I came here for, but that made me laugh.
I wanted to share this article that I came across yesterday.
https://jamanetwork.com/journals/jama/fullarticle/2776738?guestAccessKey=b6dd48f3-8a4e-40f3-a7c4-e92e70295022&utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jama&utm_term=mostread&utm_content=olf-widget_02222021#note-JOI200145-1
Conclusions and Relevance:
Among hospitalized patients with COVID-19, a single high dose of vitamin D3, compared with placebo, did not significantly reduce hospital length of stay. The findings do not support the use of a high dose of vitamin D3 for treatment of moderate to severe COVID-19.
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MP Phase1 23Mar_06; Phase2 July 10_06; Phase3 Nov 4_06. Dx Thyroiditis (Thyroxine); arthritis; glaucoma; CFS (1988-92);Kidney & bladder probs., Osteoporosis Dx 2015, Burning Mouth Syndrome! 2016. Feb06 1,25D=43.3; Aug07 1,25D=27.5; Feb06 25D=44; Mar08
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Joyful
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Posted: Wed Feb 24th, 2021 21:33 |
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Claudia wrote:
Conclusions and Relevance:
Among hospitalized patients with COVID-19, a single high dose of vitamin D3, compared with placebo, did not significantly reduce hospital length of stay. The findings do not support the use of a high dose of vitamin D3 for treatment of moderate to severe COVID-19.
GOOD.
I've been waiting for this to get looked at. They are still blinded by the repeated "fact" that raising 25D is going to help people fight a virus.
Nobody is raising a flag and pointing out the fallicies. Maybe now with this study we have a soapbox to stand on.
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Claudia
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Posted: Thu Feb 25th, 2021 11:28 |
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Joyful,
Yes, as usual, they confuse correlation with causation.
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MP Phase1 23Mar_06; Phase2 July 10_06; Phase3 Nov 4_06. Dx Thyroiditis (Thyroxine); arthritis; glaucoma; CFS (1988-92);Kidney & bladder probs., Osteoporosis Dx 2015, Burning Mouth Syndrome! 2016. Feb06 1,25D=43.3; Aug07 1,25D=27.5; Feb06 25D=44; Mar08
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