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Prof Trevor Marshall
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Even a short time on antipsychotics may increase the risk of heart disease:

http://www.reuters.com/article/2011/02/09/us-antipsychotics-heart-idUSTRE71871020110209
 
http://archpsyc.ama-assn.org/cgi/content/abstract/archgenpsychiatry.2011.2v1
Foley and her team looked at 25 previous studies that had tracked risk factors for heart disease in patients taking older or newer antipsychotics. These included high blood pressure, cholesterol levels, and body weight.
They found that across all the studies, six to seven of every 10 people on antipsychotics were overweight after six months. Before taking the drugs, only about four of every 10 were overweight, the same as in the general population.


jrfoutin
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Interesting. Some might question if anti-psychotics are suppressing or stimulating immune function to favor pathogen success over immune system.

Other studies cite tachycardia, hypertension, arrhythmia and and atherosclerosis as common comorbidities, and we saw that in our Bipolar cohort. There is certainly a link.

Olmesartan is renal protective, but I've often wondered if it wasn't highly cardio-protective as well. Weight returning to healthy levels over time seems to be the MP pattern also (underweight or overweight to norms, as underweight is a huge problem for anorexic hearts as well).

This quote is worth keeping too:
About one in 100 adults in the U.S. has schizophrenia, according to the National Institute of Mental Health.

That would mean that just about everyone knows someone already diagnosed and expected to comply with the standard of care for same.

titta
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......on the other hand when those researchers would look  at all those lab parameters which change over the course of the MP (in the first 1-2 years for the 'worse' ) they would probably  prove using their statistics and old data that you cannot survive on the MP  ??

Titta

Russ
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Antipsychotic Drugs May Reduce Brain Tissue Volume:

http://www.modernmedicine.com/modernmedicine/Modern+Medicine+Now/Antipsychotic-Drugs-May-Reduce-Brain-Tissue-Volume/ArticleNewsFeed/Article/detail/707553?contextCategoryId=40153

 

titta
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Hi Russ,
very interesting study.

The only 'flaw' I can see is that severity of illness is mostly accompanied with more antipsychotic drug 'intake' so I really wonder how they were able to correctly differ these parts.
Nevertheless, the conclusion made, are correct and fit that many neuroleptica have immunsuppressive abilities which palliate the symptoms but do not cure the disease, obviously the opposite.
Imaging a study using the MP is my dream but I see problems regarding acute symptoms which need to be palliated as soon as possible when acute agressions against oneself or others appear. That then would be a theme to discuss and adapt the study design.

Take care,
Titta



jrfoutin
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I appreciated the researcher's nod to concerns for off-label use for related psych dx.

As general public and professional awareness of % of psych dx comorbid to autoimmune disease (% varies), then studies like this can help medical consumers discuss concerns with their prescribing medical providers.

Abstract here:

http://archpsyc.ama-assn.org/cgi/content/short/68/2/128

Note conclusion:

"...suggesting the importance of careful risk-benefit review of dosage and duration of treatment as well as their off-label use."

Best to all--Janet

titta
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Alas, so called modern atypical neuroleptica are very BIG BUSINESS.
Nearly every day you can read a new suggestion to use them in different diseases from anxiety, eating disorder, OCD, autism, neurodermitis, the newest ALS (even their side effects are marketed - becoming fatter might prolong life???? Charite Berlin Neurology).
And I have to admit that esp psychiatrists just follow......(they are those with the most Dollar-connections to industry...).


Titta
 


tussilago
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After about a year/one and a half year on Quetiapin (Seroquel, anti-psychotic drug) my hearth started to beat really fast an hour or so after I took the medicine in the evening. The psychiatrist I talked to said this can happen.

Last edited on Wed Dec 28th, 2011 05:01 by tussilago

Marysue
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When I was very sick pre-MP, my heart would start racing like that in response to certain medications, as well as foods with high D, and even food/drink with high chlorogenic acid. 

Now that I am seeing my response to these things diminish over time, my view in hindsight is that as we become increasingly ill, the immune system/body begins to respond in an every increasing "panic" whenever we take something that slows or stops immune activity, particularly via the VDR.

It is as though we are already struggling with the bacteria, but if something shuts down the immune system's ability to respond, our body sets off alarms to tell us we are in even more trouble--and to encourage us not to consume more of that substance or medicaton.   

It seems that so many of the medications that alter psychiatric symptoms seem to have a significant effect on immune activity--and pain meds too as we are discussing here:
Understanding the effects of taking Ibuprofen

Marysue

Dmitry
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https://pubmed.ncbi.nlm.nih.gov/19138716/
There is considerable evidence that schizophrenia is associated with immune system dysregulation. For example, blood and cerebrospinal fluid (CSF) levels of proinflammatory cytokines are significantly increased in schizophrenic patients, and their normalization correlates with improvement in psychotic symptoms. In fact, typical and atypical antipsychotics are reported to modulate immune function in in vitro and in vivo studies. In the present study, we examined the anti-inflammatory effect of antipsychotics, clozapine, olanzapine, risperidone and haloperidol, on serum cytokine levels in lipopolysaccharide (LPS)-treated mice. Atypical antipsychotics, such as clozapine, olanzapine and risperidone, but not haloperidol, suppressed tumor necrosis factor (TNF)-alpha and interleukin (IL)-6, and up-regulated IL-10. Moreover, only clozapine, robustly increased the serum levels of IL-10. Clozapine reproduced its anti-inflammatory feature in polyinsinic-polycytidylic acid sodium salt (Poly[I : C])-induced inflammation. Thus, the anti-inflammatory effect of clozapine would adapt to inflammation induced by some varieties of antigens. Several receptor ligands, such as 8-OH-DPAT, ketanserin, prazosin and scopolamine, were also examined as to their anti-inflammatory effects on serum cytokine levels in LPS-treated mice. Ketanserin and prazosin, but not 8-OH-DPAT nor scopolamine, behaved similarly to atypical antipsychotics. However, the remarkable increase of serum IL-10 level observed in clozapine was not detected in ketanserin and prazosin. These results suggest the unique efficacy of atypical antipsychotics in the suppression of proinflammatory cytokines, and the increase of anti-inflammatory cytokine, IL-10.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897763/
Antipsychotic treatment altered immune function by raising the levels of anti-inflammatory cytokines (IL-4 and IL-10) and suppressing the levels of pro-inflammatory cytokines (IFN-γ).

seanlane
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The antipsychotic medication, risperidone, causes global immunosuppression in healthy mice

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0218937

New study shows antipsychotic drugs can suppress the immune system. Researchers at the University of New England who have been studying the side effects of drugs for more than a decade have discovered that antipsychotic drugs are getting into bone marrow, making it difficult for them to fight off infections.Aug 14, 2019

https://www.une.edu/news/2019/new-study-shows-antipsychotic-drugs-can-suppress-immune-system

The active ingredient in respiradone,
paliperidone, now conveniently renamed Invega is directly responsible for suppressing my immune system and causing massive HHV-6 reactivation in spine, heart and lungs. During the 4 months where I was pumped full of ' time released Invega' I completely lost my ability to walk or right and went into dementia. After released from hospital my spine was inflamed from top to bottom..which was later confirmed to be HHV-6 , more commonly seen in immunocompromised individuals, transplant recipients as well as chemotherapy recipients (oxidative stres in large amounts suppress immune system and sets the body up for viral replication)

Needless to say, it was very immunosuppressive.

seanlane
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seanlane wrote:
The antipsychotic medication, risperidone, causes global immunosuppression in healthy mice

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0218937

New study shows antipsychotic drugs can suppress the immune system. Researchers at the University of New England who have been studying the side effects of drugs for more than a decade have discovered that antipsychotic drugs are getting into bone marrow, making it difficult for them to fight off infections.Aug 14, 2019

https://www.une.edu/news/2019/new-study-shows-antipsychotic-drugs-can-suppress-immune-system

The active ingredient in respiradone,
paliperidone, now conveniently renamed Invega is directly responsible for suppressing my immune system and causing massive HHV-6 reactivation in spine, heart and lungs. During the 4 months where I was pumped full of ' time released Invega' I completely lost my ability to walk or wright and went into dementia. After released from hospital my spine was inflamed from top to bottom..which was later confirmed to be HHV-6 , more commonly seen in immunocompromised individuals, transplant recipients as well as chemotherapy recipients (oxidative stres in large amounts suppress immune system and sets the body up for viral replication)

Needless to say, it was very immunosuppressive.

jrfoutin
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Yikes! Glad you are off those now.

Thanks for the heads up. Most Rx seem built around immune suppression. This seems easiest way to get a study and test for new drug because people will show immediate symptom reversal (immune battle ceases).

The commercials small print/fast speak for a lot of new biologics are generally easy to flag as immune suppressants as well. "Buyer beware" seems appropriate, as is reading the studies leading to Rx roll out.

It must be awful when a doctor realizes their years of schooling/debt and hope of helping patients is almost exclusively limited to hauling patients into immune suppression concentration camps to await death.

Thanks for the heads up Seanlane--Janet



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