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Prof Trevor Marshall
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And hopefully you will like the changes :)

http://www.youtube.com/watch?v=OAwxzQCjXM4

..Trevor..
 

mvanwink5
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I keep sending the information to my friend with MS and his doctor. One can always hope...

Thanks!

Mike

ChrisMavo
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Excellent presentation Dr Marshall!  I am certainly glad you noticed the camera thief in time!  :D

I have a question though.  At approximately the 25 minute mark of the video you make a comment about ALS that I found intriguing!  You stated as one of your bullet points that "By the time the brain becomes infected, many systemic disease pathways are already active ... and vice versa!"  Then you added the curious part for me when you went on to add "... with a few exceptions like ALS. Which I am obviously intrigued with."  Can you clarify this for me and explain why you think ALS is an exception to this bullet point? 

Thanks! 

Prof Trevor Marshall
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Chris, your mind still seems relatively clear to me. Especially by comparison with others who are able to walk and talk, but are struggling against 'mental demons'. There seems to be separable brain functions driving the sympathetic nervous system (which has largely failed in your case) and those driving cognition, and etc (which appear largely intact).

I am fascinated by it, as Medicine thinks all brain functions are focused on neurons, and neuronal interconnections. But I am not so sure. I met a German engineer at the DNA-day conference who has hypothesized that memory is stored in electromagnetic waves in a vacuum in the brain, a tiny 'black hole.' Now most wrote this concept off as crazy, but I was thinking about his ideas, and while I am pretty certain there is no 'black hole' in the brain, I do think that the junk DNA may be the mechanism whereby some, or all, memory is retained, and whereby innate instincts are communicated between generations (that is my idea, not his :) )

I have some ideas how this might happen, but it is too early to put voice to them at this time... So let's just say I am 'intrigued'...

..trevor..

Liopluridon
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It's like a group of people taking a very long walk.  The horizon is hazy until you get there and people will have different details of what they saw along the trip.  But the good thing really is that there is that horizon.

ChrisMavo
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Thank you Dr Marshall for your reply! 

I have NO cognitive impairment at all ... as evidence in my current chess tournament I am undefeated at 8 and 0!!  So ... YES ... ALS does not seem to impair the cognitive functions at all.  But it sure does effect ALL my emotions and my motor skills!  Even laughing, crying, coughing, sneezing and sexual response are all extremely exaggerated now and nothing like before I got ill!!

Maybe ALS is a unique mix of pathogens that ONLY goes after a select portion of the CNS.  That could explain why my blood work seems to be normal in all regards ... even though I have been on the MP for almost 2 years!  It could be that ALS is not preceded by systemic disease. 

I just hope that ALS will eventually respond like the other serious diseases responded to the MP!  So far it is hard to tell if what I am experiencing is IP or simply the normal slow progression of ALS that some patients exhibit.

Thanks for posting yet another EXCELLENT presentation ... it is appreciated that you share all these conferences with us!!

Prof Trevor Marshall
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Chris, It's a balance between the relative likelihood of ONLY a specific type of neuronal activity being affected, and the likelihood that a different brain function is involved. All the more interesting because of the disconnect with social skills.

wrotek
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I have noticed on the video, that olmesartan is a partial agonist for VDR. I wonder, how partial is it ? How does one measure, or simulate, percentage of receptor activity ?

I guess that experimentally, by counting the number of products of the genes, that this receptor expresses. But is it possible in-silico ?

Last edited on Wed Jun 8th, 2011 02:41 by wrotek

mvanwink5
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VDR-olmesartan stability is less than VDR-1,25D stability, so that is one chemical difference.

wrotek
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So affinity determines that ? Time ligand spends in LBP ?

mvanwink5
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As I recall it had to do with additional hydrogen bonding for the 1,25D ligand.

wrotek
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What if one finds agonist that binds more strongly than natural ligand, in this case 1.25-D, if it is actually possible, how would one call it. Super agonist ? :)

mvanwink5
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If it doesn't provide palliation too, definitely yes. :cool: Also what about affinity for other nuclear receptors? Maybe a group added to 1,25D that lowers its affinity for the other nuclear receptors?

GeorgeinRollaMO
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Trevor,

You said above, "...whereby innate instincts are communicated between generations (that is my idea, not his :) )"

I remember reading in the later 1960's or early 1970's ( I think ) that some researcher did some work with earthworms.  He subjected a group of them to bright light flashes, watched their reaction to it in a certain fashion, then ground them up and fed them to a later generation of earthworms, then repeated this a number of times.  Towards the end of this experiment, he was noticing that the latest generation was reacting to light in the same fashion as the earlier generation.  I have forgotten the full details.  I don't remember his name, etc.  However, he thought (and I did too) that the experiment showed that knowledge MAY be able to be handed down between generations. 

I am descended from a line of architects/carpenters, and seem to have a very strong ability along this line.  Yet, no one of them has/was able to teach me.

Music seems to run in families, as does other abilities as well.

I think that your idea is a viable one.

Good presentation! ;)

Wishing all wellness!!! :D

Dark Vader...aka, George

mvanwink5
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Planaria worms were used in that experiment, which was a type of flat worm; I remember that experiment. Was it ever explained how the memory was transmitted?

Best,

Mike

Markt9452
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I know it's pinned but I am bumping it anyways...

BUMP

Prof Trevor Marshall
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The PDF transcript of the NeuroTalk conference, which you can print for your Doctor, etc, is available from

http://AutoimmunityResearch.org/transcripts/Marshall_NeuroTalk2011.pdf

My sincere thanks to Janet for her wonderful work :) :)

..trevor..

Deedee
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Janet thank you so much for your hard work with the transcript. I can't watch videos on my camera and this was very helpful. D.

Prof Trevor Marshall
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The video is now also on Vimeo, at URL http://vimeo.com/25619468

You can download a copy of the video from Vimeo, if you have a slow internet connection. That way you can watch it on your computer using VLC ( http://Videolan.org ). The download link is at the bottom right edge of the page. You have to be a vimeo member (free) to use the download capability.

Enjoy!
 

Deedee
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Thanks for the tip! I usually try to watch this away from home, as I am on Hughes Net. It connection is s.l.o.w. and with tons of starts and stops, but even worse is that they throttle you if you download too much. It stinks, but it is all we have available to us. I live way back in the woods on the side of a mountain. :)

I so much appreciate the transcript so I don't have to wait to hear what info you are sharing with us on the video.

Last edited on Sun Jun 26th, 2011 06:21 by Deedee

wrotek
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Dr Marshall talks about microbiome and sterility of the human body, I wonder how brain sterility looks like ? Does it also contain microbes on a regular basis ? Or is it better protected ?

mvanwink5
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Wrotek,
I have the point of view that propensity to addiction is likely brain infestation. My paternal grandmother was well known for her rages, reminds me of "lyme rage." I am starting to see bugs everywhere! Haul me off quick.
Best regards,
Mike

mvanwink5
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Looking for bugs? This would be nice to use.
http://www.youtube.com/watch?v=woWMgGdzn0M&feature=player_embedded

Phillyguy
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Pair it with bug searching algorithms and remove the user.



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