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Vitamin D no help in COPD
 Moderated by: Prof Trevor Marshall
 

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Prof Trevor Marshall
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Joined: Fri Jul 9th, 2004
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 Posted: Tue Jan 17th, 2012 06:29

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paper is available for free at: http: //www.annals.org/content/156/2/105.full.pdf+html

They used 100,000 units every 4 weeks (that's only 3500 IU a day, the critics will say, not enough! )

I have a vivid memory of seeing a poster, at one of the recent conferences I attended, of the COPD microbiome. In healthy people there were lots of species in their lungs, but in COPD that changed to a preponderance of Pseudomonas.

Problem is, the study doesn't seem to have been subsequently published (no surprise really, the pulmos would be jumping up and down to suppress a paper like that) and I haven't seen any more posters in any of the other lung diseases (same comment about over-excited pulmos applies).

Maybe I dreamt it all up :X :X

I guess, by the time COPD is diagnosed, the gentle immunosuppression of Vit-D is of little use. Except to the few who were really very ill, with 25-D less than 10ng/ml :)

..Trevor..
 

Seth
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 Posted: Tue Jan 17th, 2012 07:36

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its kind of a shock to see that 9 of the patients receiving D died and 6 receiving placebos died. Thats 8% of their test group. I know they are severe cases, but it seems they would have fared better on the MP..

I wonder if the higher death rate in their next study will correlate with their higher levels of supplementation (and will they notice?).

Last edited on Tue Jan 17th, 2012 07:38 by Seth



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Seth
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 Posted: Tue Jan 17th, 2012 13:53

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I do remember reading a paper that identified pseudomonas in bronchoalveolar lavage fluid. (I think) that was around a year ago.

Here's a recent one examining the microbiome in "healthy" smokers and in COPD:
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0016384

Luckily, more are recognising the fact that parts of the body that were thought sterile, are actually not.

Actually, my respiratory doc, that I saw once and fired has done work to identify
"Disordered Microbial Communities in Asthmatic airways":
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0008578
Unfortunately, last time I read the news, he seemed to be occupied with promoting a drug that reduces use of hospital beds by COPD patients (and hence less expenses).

Last edited on Tue Jan 17th, 2012 13:53 by Seth



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Sarcoidosis |dx-Sep'09|Ph1-Mar'10|Ph2-Jul'10|Ph3-Jan'11|O-only-Aug'11|bone marrow biopsy|splenomegaly,lungs,joint/muscle/stomach pain,sweats,fatigue,headaches,mood swings,brain fog |25D<10ng/ml-Dec'10-June'11| Splenectomy June 2016. DEATH TO THE BUGS!
Frenchie
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 Posted: Wed Jan 18th, 2012 01:30

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This is another study of the microbiota involved in athsma:

16S ribosomal RNA amplicon concentrations (a proxy for bacterial burden) and bacterial diversity were significantly higher among asthmatic patients. In multivariate analyses airway microbiota composition and diversity were significantly correlated with bronchial hyperresponsiveness. Specifically, the relative abundance of particular phylotypes, including members of the Comamonadaceae, Sphingomonadaceae, Oxalobacteraceae, and other bacterial families were highly correlated with the degree of bronchial hyperresponsiveness.

http://www.jacionline.org/article/S0091-6749%2810%2901760-4/fulltext



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Gulf War Syndrome, 1,25D 62 pg/ml Oct09, Ph1Jan10, 25D 9 ng/ml Mar 13
jlunn247
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 Posted: Wed Jan 18th, 2012 06:32

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Just saw the headline right below WIKI PROTEST about 4th story down.lucky day!



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jlunn247
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 Posted: Wed Jan 18th, 2012 06:36

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1 DEATH = 2 FAILURES not getting better & not helping to live! I dont see that any died or were any deaths in the headline story must be in the pdf.
p.s. thats my heart or Solar pLexus ct.

Last edited on Wed Jan 18th, 2012 08:02 by jlunn247



____________________
Living in the land of the lost. JUST OLMECIP 5 x a day.Sarcoidosis Dx.
Bone disintegration,lungs,joint/muscle/stomach pain, diarrhea,incontinence. Weakness on my left side sweats,fatigue,neuropathy,headaches,mood swings,cognitive diss.

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