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Prof Trevor Marshall
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Researchers have used whole genome sequencing to reveal if drug-resistant bacteria are transmitted from animals to humans in two disease outbreaks that occurred on different farms in Denmark. The results, which are published today in EMBO Molecular Medicine, confirm animal-to-human transmission of methicillin-resistant Staphylococcus aureus

http://goo.gl/gi3nN

http://onlinelibrary.wiley.com/doi/10.1002/emmm.201202413/full

The significance of transmission from food to humans on one's microbiome composition is covered in all my recent presentations...

These researchers did not investigate the pathway of transmission, but Eric Alm's work has already identified food as a pathway.

mvanwink5
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Dr. Marshall,
Has this been with us for a long time and now known because of new techniques or is this a new problem? In other words is there a trajectory for this or is it stable at a low level?

mvanwink5
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One of the infected patients had a steroid injection coinciding with the infection too. Significant innate immune suppression a necessary cofactor?

Prof Trevor Marshall
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Immunosuppression is always a factor. That's why so many sarcies die of C.difficile and lung infections (pneumonia).
 
I am sure this pathway has always been there, but while mankind didn't travel much it would only have caused problems in their marauding armies :)

GillyB
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Humans have lived with, and shared microbiome with their domestic animals for centuries (millenia!), since animal husbandry became part of our lives.  The study of influenza and it's mutations shows a clear vector trail from wild birds, to domestic birds, to domestic pigs, to humans and thru their travels, to a worldwide audience.  Exposure to cowpox helped milkmaids develop immunity to smallpox.  I don't have any trouble accepting that plenty of other members of the microbiome can share hosts with domestic animals and humans.

It's only now that prophylactic use of antibiotics in overcrowded feedlots (or as the US government labels them, concentrated animal feeding operations, or CAFOs), and overzealous use of antibiotics for human ailments, has forced evolution on to such a common shared bacterium. 

Last edited on Sun Apr 7th, 2013 11:09 by GillyB

Prof Trevor Marshall
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Gilly, I would say that it is only now, with the compromized immune systems of so many humans, that these pathogens have started to become a real problem.

I lay the blame on steroids, and Vit D supplements, more than on antibiotics :)

GillyB
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Yep, agree that's a big part of it too.  I suppose if you have a fully active and health innate immune system, you could fight off MSRA or tuberculosis.

mvanwink5
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I wonder if olmesartan dosing at 40 mg q4h would prevent MRSA or tuberculosis from gaining a foot hold? Is blocking the VDR an early strategy for infection or a later strategy for infectious agents? I can see how a body with prior partial VDR inactivation would increase infection likelihood, but how central is shutting down the VDR to acute infections? Any ideas?

Prof Trevor Marshall
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We haven't seen any serious acute infections in the cohort during the first decade. No MRSA, no TB. Compared with a cohort on TNF-alpha drugs, for example, that is really an exceptional result.

mvanwink5
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I think that is significant. Thanks.

stuckpac
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And don't forget about the rest of us out here who weren't early enough to begin the MP with the cohort you are following and thus you have no data on. I am nearing 5 years on the MP which I began on my own and since beginning the MP can say with reasonable certitude that I haven't experienced any significant illness in those 5 years. No bronchitis, colds or flu like I used to get all the time, not to mention TB or MRSA. I work in a hospital and am exposed to all sorts of microbes on a daily basis. I examine people who cough and sneeze on me. I should "knock on wood" somewhere...... probably get sick tomorrow.....now that I've said this :-) But I really believe that it is due to my immune system getting back on track and giving me much better protection than it used to. What I find really interesting is that over those 5 years, every now and then, I will experience the symptoms of, you know what people say, "I think I am coming down with such and such....a cold, etc." I start feeling a bit chilled. And I think, this time I'm getting sick for sure. And it lasts for about 24 hours and goes away. I really wonder if this just isn't my immune system having met a new bug, ramping up, fighting for me and then it's gone....

Prof Trevor Marshall
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I am watching everybody who posts their progress, even if they were not early adopters. I would welcome you posting reports on your progress, stuckpac :)

Ron
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stuckpac wrote: What I find really interesting is that over those 5 years, every now and then, I will experience the symptoms of, you know what people say, "I think I am coming down with such and such....a cold, etc." I start feeling a bit chilled. And I think, this time I'm getting sick for sure. And it lasts for about 24 hours and goes away. I really wonder if this just isn't my immune system having met a new bug, ramping up, fighting for me and then it's gone....
That is exactly what happened to me last week. And unlike many other people in my environment I have not had a two weeks lasting flu.

Ron
Pushing five years MP. :)

Last edited on Mon Apr 8th, 2013 22:22 by Ron

Cairo123
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I do not recall having the flu or a cold for several years.

Hogan
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I must be the exception to the rule here.  I am still getting multiple infections every year even with almost 5 years on the MP.  These are not IP reactions they have been documented infections etc using blood work.   I get everything that I come in contact with.  My D values are in the therapeutic range.  Don't get  me wrong I have had improvements but I was hoping that I would be able to hold my own a little more than I can yet.  :X 

I'm glad that the majority of people seem to be able to get rid of acute infections before they take hold but I have seen a few people like me here and I'm not sure what else can be done but it would be nice to figure it out. 

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I had c diff in 2010 but that was after the immunosuppressive treatment I had. This winter I have had every viral thing on the go, but even with my WBC at or below 1 and being neutropenic, I seem to be able to fight stuff off just like everyone else, and I haven't developed pneumonia or anything that might be expected from someone with my counts. Now I feel like I need to knock on wood! LOL.

Deb

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Nine years completed  MP (no breaks) and still multiple and lasting flu, cold and bronchitis.  No change in  severe and immediate particulate response, either.  Seems  I have had little or no improvement in mucosal immunity nor cellular immunity, nor complement system, nor adaptive immune response in general.  If there is anything in the works for this, would be happy to hear about it.

Otherwise it seems to me i have something outside the range of MP protocol.  Think i qualify for gammaglobulin (because of compliment panel and other immune tests) and will be looking into this for next winter/spring the worst 6 months.  Will see if can be injection as opposed to infusion because of fewer donors.

Would appreciate anyone's input.

 

Frenchie
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I have had a lot less human contact since starting the MP, so while I have had very few infections during the three years it may just be from lack of exposure.

To get back to the thread, this talks about the use of steroids in beef, and it would be interesting to know how they affect the presence of CWD forms in meat, particularly when they are combined with non therapeutic use of antibiotics:

There are six hormones approved for use in beef production in more than 30 countries.  Three of these are natural, three synthetic. The three natural hormones (testosterone, estradiol, and progesterone)....

The three synthetic growth enhancing hormones are melengestrol acetate (MGA), trenbolone acetate (TBA), and zeranol. These are more stable analogs of the three natural hormones....

The science indicates that use of supplemental hormones in cattle has only a miniscule impact on hormone levels in beef – well below the natural hormone levels in beef or the amounts produced naturally in our own bodies....

Comparing conventional beef production to an alternative grass- based beef production system using an economic/production model created by scientists at Iowa State University shows that growth promoting hormones and ionophores decrease the land required to produce a pound of beef by two thirds, with fully one fifth of this gain resulting from growth enhancing pharmaceuticals.

http://www.cgfi.org/pdfs/nofollow/beef-eco-benefits-paper.pdf

Prof Trevor Marshall
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Dogster,
I see Tramadol on your list of meds. How often do you have to use that?

Lee
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I helped to care for my dying mom who had MRSA along with other health problems.  I was careful but not to the extreme.  I always made sure I had as much Benicar as I could tolerate and also mino during the times I lived with her. 
I am 8 years in the MP now and far from a poster child seeing as I can still only tolerate 20mgs Benicar 3-4 times per day.  I have taken several abx breaks.
My biggest complaint now is cystic inflammation or granulomas.  No doc can tell me for sure.  I also have high levels of anxiety.  This could be just general stress from aging and life issues.  I did take Ativan and Lyrica during the years of 2007-2010.
Not at the same time ....used Ativan to wean myself off of Lyrica!  The choice of these meds were my docs as they would not give me opiates or Valium.  I am sure the Lyrica slowed my recovery.  I am now in pain management and am given opiates that I use sparingly.  I am still much better off on the MP than off ...:D  Lee

Dogster
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Tramadol: hardly ever.  I've had a script for it for long time, but never found it(very) effective, so used it little. Did find in 2009 with broken leg that it helped leg pain.  But that was a long time ago by now.

Prof Trevor Marshall
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Hmm. well its not that, then. When friends are struggling I usually scan the 'usual culprits' - non-MP drugs, supplements, therapies food, high Vit D levels, etc - in the hope something obvious will pop up.



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