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Our Presentation at the FDA CDER is now online
 Moderated by: Prof Trevor Marshall Page:  First Page Previous Page  1  2  3  4   
 

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Jvancan
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 Posted: Wed Mar 22nd, 2006 10:46

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jdc schreef:

OK, so then I tried to download Azureus and got very frustrated trying to make sense of it. Who ever designed the user interfaces for these products? For me it was totally confounding. I tried to find out ways to "enter in" magnet files, and then torrent files (or whatever they are). I even spoke to a software engineer with a Harvard Engineering degree. He confessed that he had no idea what a torrent file was and had never heard of Azureus.


Jim,

With al respect....It probably says more about the scope of the engineer then about Azureus and Torrent files. You can open torrentfiles just by clicking on them, how could it be simpler? A magnet file could be opened by "Open --> Torrent --> New URL".

But with a 56kbs connection it would surely cost you more on telephone bills then buying Dr. Marshall's DVD by mail.

Regards,

Jeroen

Frans
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 Posted: Wed Apr 5th, 2006 03:50

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dr Marshall,

I am looking at the presentation over and over and have more questions than answers  :D

Question: I can see prednisolone severely affects PPAR alpha and GCR (Glucose), is that perhaps a reason why people taking this drug usually gain weight?

Sincerely, Frans



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Prof Trevor Marshall
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 Posted: Wed Apr 5th, 2006 06:35

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Frans,
The acronym "Glucocorticoid" is explained here
http://cancerweb.ncl.ac.uk/cgi-bin/omd?glucocorticoid

However, the function of the receptor called the GCR is not fully known, as mice who are bred without it do not survive gestation. Additionally, some Glucocorticoids are now known to have greater affinity for the MCR (MineralCorticoid Receptor) than they have for the GCR. Just as nomenclature got it all wrong with 'Vitamin' D, so the nuclear receptor names do not uniquely define their function.

As you surmise, any drug that affects PPAR-alpha, and, to a lesser extent, PPAR-gamma, can be expected to affect a patient's weight.

Frans
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 Posted: Sat May 13th, 2006 04:23

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Dr Marshall,

Something dawned on me when I was reading the pdf file again.

It states that PPAR alpha attenuates oxidative stress. Looking at all the numbers, one can see that PPAR alpha is hit heavily by D3 and 1,25D.

I know it is simplifying things, but I would say that the oxidative stress that is reported (?) in this diseases appears to be caused (or at least not stopped) because of the high levels of the D-metabolites.

This then implies that bringing the D-metabolites to normal levels, the body automatically starts attenuating oxidative stress also?

Sincerely, Frans



____________________
Burn-out/nervous breakdown Jan01 125D 48 25D8.48 Ph1Nov06 ModPh2Jan07 Ph2Apr08 Cipramil Seroquel NoIRs lite exp r/t work cover up 25D3.9(Oct07)
Prof Trevor Marshall
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 Posted: Sat May 13th, 2006 06:58

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Frans,
Look at the effects on NO (nitric oxide) metabolism, they are even more profound:)

Frans
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 Posted: Sun May 14th, 2006 11:25

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Trevor, You haven't published that yet  :)

I have been looking around on KEGG but can't find what you mean. Have tried pubmed also, but have to look further, I'll try VDR and nitric oxide.

Sincerely, Frans



____________________
Burn-out/nervous breakdown Jan01 125D 48 25D8.48 Ph1Nov06 ModPh2Jan07 Ph2Apr08 Cipramil Seroquel NoIRs lite exp r/t work cover up 25D3.9(Oct07)
Frans
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 Posted: Thu Jan 18th, 2007 10:51

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Trevor, I know this thread is 7 months old, but I still don't get it  :?

Can you give me a lead where to start looking?

Sincerely, Frans



____________________
Burn-out/nervous breakdown Jan01 125D 48 25D8.48 Ph1Nov06 ModPh2Jan07 Ph2Apr08 Cipramil Seroquel NoIRs lite exp r/t work cover up 25D3.9(Oct07)
Prof Trevor Marshall
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 Posted: Thu Jan 18th, 2007 11:59

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For an introduction to the topic, look at PMID 16020752
http://tinyurl.com/6y3nr

The PPAR gamma receptors are tightly involved in the body's response to NO, which is produced as the bacteria are killed. Elevated NO produces elevated Blood urea Nitrogen, inter alia...

Frans
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 Posted: Thu Jan 18th, 2007 12:03

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Thank you Trevor, this helps!



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