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Prof Trevor Marshall
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The video of our presentation has been catalogued in the FDA Biosciences library, and your library can even request it on InterLibrary Loan (I think).
I guess that if you want to cite the presentation in a paper you would use something like:
"Marshall TG: Molecular genomics offers new insight into the exact mechanism of action of common drugs - ARBs, Statins, and Corticosteroids. FDA CDER Visiting Professor presentation, FDA Biosciences Library, Accession QH447.M27 2006"

An online 'RealVideo 9' version of the DVD of my FDA CDER presentation is available online at url
http://autoimmunityresearch.org/fda-visiting-professor-7mar06.ram

The running time is 1 hour, including question-time. I suggest you set your viewer to "Double Size" or "200%" so that the image is a little larger.

A copy of the slides, in Adobe Acrobat PDF format, is at URL
http://autoimmunityresearch.org/fda_visiting-professor_7mar06_144dpi.pdf

The original DVD of the presentation can be requested from
http://autoimmunityresearch.org/fdacder.htm

..Trevor..

ps: The presentation is 50 megabytes in size, and it can be downloaded in total by right-clicking on this link
http://tinyurl.com/n8bvf
(Thanks to John McDonald)

Last edited on Sat Mar 18th, 2006 23:30 by Prof Trevor Marshall

Frans
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dr Marshall, I can't download by right clicking, is it supposed to be that way?

sincerely, Frans

Prof Trevor Marshall
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Frans,
If you need to download the presentation to your disk, for example if your Internet connnection is too slow to stream online, then please right-click on this URL:
http://autoimmunityresearch.org/fda-visiting-professor-7mar06.rm

It is a 50 megabyte file.

paulalbert
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Why don't you upload the complete original to Google Video? YouTube also has free hosting. Their servers are pretty snappy. If you need help converting the file to an appropriate format, I would be happy to help.

Paul

Prof Trevor Marshall
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Paul,
The DVD itself is 1.6 gig big. I was thinking of setting up a torrent for those who can master that technology, but haven't had any experience with Google Video. Like I said, if you can offload the work from me I would would be happy to help:) I am using the Vegas 6.0 editor, and can export the presentation in a variety of formats.

Note that I have just received the FDA Biosciences Library accession number, and have put that up in my starting message (above)

Frans
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Oh man, I am only at minute 20 and already I am totally blown away

dr Marshall, you are totally incredible

one question, the Methicillin Resistant Staph Aureus you mention in the beginning of your presentation, is that the elusive MRSA bacteria hospitals are so afraid about?

Am I right if I understand they are susceptible to ARB's?

Sincerely, Frans

Jvancan
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Thank you, Dr. Marshall for the great work and effort!

It would be nice if you could set up a torrent for the whole 1.6Gig version.

Thanks again,

Jeroen

Prof Trevor Marshall
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Frans:
Yes, MRSA252 is one of the "superbug" species.

My modelling shows the MRSA252 genome will respond to the presence of ARBs, just like the other bacterial species behind Th1 disease.


Jeroen:
I have set up a torrent for the ISO of the DVD at URI
magnet:?xt=urn:btih:FADD7OKE5TODIOR7NAQSBQDP7FQIVNFR

Those of you who are torrent-savvy should be able to access the torrent now (copy and paste the magnet to your browser URL window)(I can see that Jeroen is now downloading it OK) - and remember - please keep seeding the torrent to help overall bandwidth...

Last edited on Wed Mar 15th, 2006 09:39 by Prof Trevor Marshall

paulalbert
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Trevor,
If I'm not mistaken, 1.6 gigabytes is much bigger than it has to be for the purposes for a non-DVD file. I've been working on converting my family's home movies and based on what I've seen doing that, you could reduce the file size by a factor of 10.

That point aside, I think you might be better served to upload the file to Google Video, given the prospect of wider publicity and the trouble with downloading a torrent-based file after initial interest wanes a bit. Here are the format specifications for Google Video:

Google accepts video in a wide range of popular formats. The fastest way to get your videos into Google Video is to submit each file in MPEG4 format with MP3 audio or MPEG2 with MP3.

While we also support other digital formats such as QuickTime, Windows Media, and RealVideo, it's important to note that submitting your files in these formats may significantly delay us from using them on Google Video. In some cases, we may not be able to add your video at all.

Here are our preferred video specs:
NTSC (4:3) size and framerate, deinterlaced
Video Codec: MPEG2 or MPEG4 (MPEG4 preferred)
Video Bitrate: at least 260Kbps (750kbps preferred)
Audio Codec: MP3 vbr
Audio Bitrate: at least 70Kbps (128 Kbps preferred)


Vegas Video 6 can output MPEG-2 files. I didn't see if MPEG-4, a better conversion standard, was available. So, if you're game, I would say:
1. Output the file in MPEG-2.
2. Go here.
3. Set up an account.
4. Upload the file.

For that matter, I think it would be kind of nice to have all of your media at Google Video, unless of course you want some recompense for your cinematographic efforts. :)

Paul

p.s. If you are too busy or whatever, I would be happy to do this, once a torrent file exists.

Prof Trevor Marshall
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Paul,
The DVD datarate is already low - 3500 KBps - so a 1.7 gig ISO is about the most compact you are going to get TV quality, I am afraid. The RealVideo 9 datarate is 100KBps, and this compression format is (arguably) better than MPEG4.

The problem I have with using Google Video is that the uploads are public forever. You know, I am not really proud of some of the mistakes I made when I gave the Westlake Lyme presentation 2 years ago, and I would be embarrassed if folks stumbled across that video on the Internet and assumed it was my current thinking. It is good to be able to retire videos when you have updated material to present. Google doesn't allow that.

Anyway - the torrent seems to be working OK, so that will enable International folks to quickly get their copy of the full-quality presentation. Within the USA we can mail out the DVDs. Actually, I think the streaming online RealVideo stream is quite good enough, especially if you have a color printout of the slides in your hand :)

Frans
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Trevor,

I remember you saying at a certain day that normal/clinical and molecular medicin are still way to far apart.

If I am not mistaken, you have just bridged that gap.

This is revolutionary stuff I think, do you think that came across to your audience? Did they really fathom what you were telling them?

I also want to say that it keeps surprising me how you seem to get the most difficult information across in a way that even a lay-man like me understands exactly what you are saying.

Absolutely fantastic work!

Most sincerely, Frans

Last edited on Wed Mar 15th, 2006 10:51 by Frans

Prof Trevor Marshall
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To all:
Here is the .torrent file you should be able to just click on, and then your bittorrent program will spring into action (if you have one):
http://autoimmunityresearch.org/fda_presentation.iso.torrent
(thanks to Jeroen for finding that file)

Frans:
I think that the FDA folk didn't really understand the full implications of what I was saying. But now that a copy of the DVD is in their library there is a tangible record they can refer to whenever the opportunity (or need) arises.

Trevor

Jvancan
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And I would like to add, for the people who don't have a Torrent Downloading Client yet, here is a good one:
http://azureus.sourceforge.net/download.php

Jeroen

wrotek
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I am during watching-marvellous,the effects of wide spectrum of different ARBs actions showed on the table are amazing.

I am just curiuos, How 1,25-D is decreased if VDR is blocked ? I mean if angiotensin II type 1 receptor is blocked then body puts out more angiotensin II am i right ? But with 1,25-D it is opposite.


sorry but the torrent file dosen`t seem to be working with my bitcomet client, the error occurs "error tracker data-wrong data string "

Last edited on Wed Mar 15th, 2006 13:48 by wrotek

paulalbert
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Trevor said:The problem I have with using Google Video is that the uploads are public forever.

This is not so. Here's a snip from Google Video's FAQs:
Can I remove my videos after I upload them?

Yes. You can use the delete feature on the Video Status page to remove videos that you have uploaded to us. If the video is not yet live, it will be deleted immediately and permanently from your account. If your video is live, it will be removed from your account and the Google Video index as soon as is possible.

No matter though. Do as you wish.

Paul

Prof Trevor Marshall
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Paul,
Excellent Info. Thank you. I will put a copy on Google later this evening (busy right now).

Wrotek, there are 5 peers connected to the Bittorrent swarm right now, with an average completion of 32%. So you should be able to connect to one of them:X I do note that the two connected to me right now are using Azureus, not Bitcomet, but that shouldn't matter.

Prof Trevor Marshall
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I was asked what the DVD of the presentation looks like.

It is in a case, slimline, 9mm thick, with a cover insert saying what the DVD is, and the DVD itself is printed with the ARF logo and a description of what is the DVD - namely just my FDA lecture, which runs for 1 hour 1 minute, including questions.

We are using a PayPal system for the First Class postage, as we get a delivery notification (we can make sure it is delivered).

The DVD of the presentation can be requested from
http://autoimmunityresearch.org/fdacder.htm

Jvancan
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Wrotek,

It works in Azureus, but I think the tracker has some problems in your client. You can also use the magnet link:
magnet:?xt=urn:btih:FADD7OKE5TODIOR7NAQSBQDP7FQIVNFR


Jeroen

wrotek
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It works very well indeed, the azureus client runs magnet while bitcomet does not

Dogster
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Can anyone address Wrotek's questions in Mar 15 post, second paragraph??

Dogster

Prof Trevor Marshall
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Dogster,
The interaction between the expression of 1,25-D, IL2, Interferon-gamma and VDR is too complex to quantify at this point. The only thing certain is that VDR is hyper-activated by the pathogens behind Th1 disease. Reducing VDR hyper-activity is clearly necessary to restore proper functioning of the immune system.

ericmarshal
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Hi,
While not sure this is the proper thread, there may be a linkage.  What possibilities does this "New" immune cell discovery add to the MP?  mm
 
 
Newly Recognized Immune Cell Unveiled in Asthma
MedPage Today - Little Falls,NJ,USA
... In a study of pulmonary specimens from 25 adults, 14 had moderate to severe persistent bronchial asthma, six were healthy participants, and five had sarcoidosis ...

Prof Trevor Marshall
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Not relevant, Eric. They were not looking for intracellular pathogens. Therefore they are not confounding out errors due to differing severities of disease condition. Even if they stumbled across the answer they wouldn't have recognized it as an answer.

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Dr. Marshall,

Congratulations! Your FDA Presentation was Brilliant!!!:D Although most of the technical information was over my head I did gain some very valuable information!:D

What fascinated me the most was your finding that the immune system is interwined with lipid metabolism......and that the cholesterol and lipid metabolism both trace back to the VDR and PPAR:D and that the PPAR affects the generation of lipids.

That was a wonderful suggestion you made to the FDA regarding a data base library for students and scientists regarding drug side effects and comparing the ARB's to the ACE drugs, etc.

The comparison charts were incredible showing the effects of the different drugs and how they affect the organs, thyroid, etc. But that the ARB's do not cause the side effects that the ACE drugs do.

It gave me a much better understanding of the role of the ARB's:cool:

And lastly, the fact that the olmesartan goes into the cells reducing the 125D hormone.

Again, you were brilliant and I feel very priviledged to be a part of the Marshall Protocol!:cool:

Sincerely,

DianeC

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I can't seem to download the torrent. I use utorrent, which I don't think uses magnets (anyone?), but I saved the .torrent file and it is coming up as usual in the list. However, it says the tracker is sending invalid data.. I can see one other peer, but no seeders. Any help?

wytnez
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I just watched the FDA presentation again and it is so amazing to see how the drugs (ARBs and Statins) affect different cell and molecules. I think that is a great idea to have data base of all the drugs and the affects and side affects they may have.

Saj

Last edited on Fri Mar 17th, 2006 17:06 by Prof Trevor Marshall

Prof Trevor Marshall
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Shadowzone,
I wish I knew more about magnets and torrents, but I don't. I can see two peers on the torrent at the moment, but they are not located in Australia. There are four seeds right now. Have you thought of leaving your question about 'magnets' on a utorrent message board? Maybe somebody could help you there?

Saj,
I edited a line out of your message. The answer is "yes," but I want to minimize embarrassment all around:)

Prof Trevor Marshall
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HEY FOLKS, those of you with full copies of the DVD - please leave your Bittorrent on as SEEDS. I currently can see Shadowzone (I presume) from Australia and a download from Germany, as well. At this point I have uploaded nearly 5 complete copies myself - the aim of Bittorrent is to share the load:):)

Jvancan
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Yes that's true. I leave mine on as a seed and Frans also does. There are a few client who seem to have problems with our tracker i guess. So when you want to be sure it works... use Azureus. And when it does not work with Azureus it's probably your firewall what is causing the problems.

DianeC
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After I viewed the presentation last night a message came on stating that if I wanted to view it again or anything else I would have to download REAL PLAYER  Is is safe to do that??  I usually hesitate downloading anything unless I am positively sure it is safe:?  Any comments?

thanks a bunch:cool:

DianeC 

Jvancan
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Diane,

I would advice if you have a Windows computer to use:
http://www.free-codecs.com/download/Real_Alternative.htm

Some advantages compared to RealPlayer :

- Quick and easy install
- It's easy to make an unattended installation
- Proper uninstallation
- No background processes
- Use a player of your own choice
- Low on resources
- No advertising, no registration forms, nothing annoying


Jeroen

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Thank you Jeroen for your computer expertise!:D  That sounds great!!  It is much appreciated!!:D

DianeC

Frans
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dr Marshall,

If I understand correctly, you have a paper finished and applied and in that paper you theoretically prove that ARBs inhibit the function of an MRSA bacteria.

Isn't this worldschocking news? Wouldn't it be a thought to explicitly name MRSA is the title of the new paper? Maybe I am not understanding the implications correctly, but this seems a discovery unmatched in its significance.

Am I missing something?

Sincerely, Frans

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dr Marshall,

I have another question. In the slides you show on the presentation, lower numbers indicate higher affinity fir the receptors.

Is that because that signifies that even at very low doses, the molecules already bind to these receptors?

TIA

Sincerely, Frans

wrotek
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I thought that ARB antibacterial properties were shown firstly with psychodelic dreams of sarcoidosis patients, but it seems that scientists knew already bacterial affinity to ARB`s while they were testing drugs in 1990`s, but they did not know what it meant . :dude: . DId they wrote papers about this interactions ? ARB are bacteriostatic or bacteriocidal ? I suppose bacteriostatic cause they put bacteriocidals to kill microbes to tissue so the ARB could bind to tissue.

BTW are there any interesting books about molecular modelling? few months ago i was reading about basics in some science magazine in Poland and saw the same molecule showed by Dr Marshall in Chicago- it was one of antibodies T-shaped :) I guess they are out of date with science :D:D;)

Last edited on Sat Mar 18th, 2006 06:26 by wrotek

Prof Trevor Marshall
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Wrotek,
I cited the early papers which noted bacteria had an affinity for ARBs in our paper a couple of years ago "Putative antibacterial actions of ARBs." At that time I had no idea of the mechanism of action, and was still focused on Angiotensin II, but you will find the historical review data there.

Frans,
I scheduled two meetings at the NIH while I was in Washington. One went well, but the other, with a senior member of NIH's research staff started off by my being told that my molecular modelling was "worthless." So we didn't get anywhere productive in that meeting. Even though he has 212 published papers, he has apparently been very slow to understand and embrace new technologies, especially genomic technologies. TPTB seem unable to see the forest for the trees.

I am also having difficulty getting the Infectious Diseases people to understand the importance of what we have discovered about the profound actions of Benicar on the pathogenic genomes. It hasn't even entered their minds that such a thing might be possible.

For example - I submitted an abstract to the ISID conference asking for an oral presentation, and I got back an acceptance, but only for a poster presentation. I am therefore inclined to not bother with that group, withdraw the offer of presentation, and look for other conferences where I can get the word out more effectively (these big conferences are very expensive to attend, even though you get a large group of researchers to talk with). You and I might understand the importance of our work, but the technology still appears to be too much like magic to TPTB, apparently.

wrotek
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"worthless" is a very strong word, i wonder were there any reasons(arguments) why it was used or just emotions. If everybody would understand then there would be nothing to do :)

Last edited on Sat Mar 18th, 2006 10:06 by wrotek

Prof Trevor Marshall
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It may have been professional jealousy, a fear of new technology, or maybe just a bad experience in the past with a research project which didn't work out. I don't know. But "worthless" was the exact word. In his second or third sentence. Followed a few paragraphs later by the question "Well, which bacterial species is it which causes Sarcoidosis, then?" followed by an unwillingness to even contemplate horizontal DNA transfer. He wanted the name of a simple, singular species. Sigh... I can understand that coming from a typical pulmonologist, but look at the subject-matter of the papers this fellow has gotten author credits for:X That stuff is complex:X

wrotek
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WHen i read terrible stories of sick people, sarc, Lyme , other, i just can`t imagine doctor using that kind of word in this background. That is why i think clinicians are the best open minded doctors to show them new options of treatment like MP, because they see suffering patients where theoretical "on paper" Scientists do not.

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dr Marshall,

Is there any way we of the cohort can put pressure on anyone by getting this message out?

It seems to me that if your next paper is published, theoretically proving that MRSA is weakened by ARB's, making them an interesting antimicrobial, or at least a medicin that could enhance the actions of abx against these dreaded bacteria, we should all be writing scientific editors in our own countries, making them aware of your findings.

We can make a sort of simplified explanation, stating what you have found, and give them links to the abstract on pubmed and possibly to the full-text, if the ARF has enough money to make that happen.

I would be happy to make a simplified explanation in Donald Duck-alike language.

At school I learned about H2O, molecules, affinity between them making news molecules etc at the age of 13 !!!, so I estimate that anyone who has finished highschool should understand the simple basics of what you have done, if explained in layman's terms.

Maybe, if I concoct a simple explanation, you can send that to the person who called this work worthless... He must have been talking about how he views his own Hippocratic oath...

Sincerely, Frans

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Especially this exerpt from the hippocratic oath is something he should read up on:

I will not be ashamed to say "I know not," nor will I fail to call in my colleagues when the skills of another are needed for a patient's recovery.

from here: http://tinyurl.com/ogre7

This seems lost in his recollection.

Sincerely, Frans

wrotek
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Just for translation pursposes, person announcing Dr Marshall is Commander Perez ?

Prof Trevor Marshall
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My mistake, he was actually "Captain Perez"
Always better to bump somebody up in rank when in any doubt at all:)
All those gold bars on the sleeves, and medals on the chest, looked quite impressive, close-up:)

wrotek
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So That is why he smiled :) Yes very impressive distinctions, i watched and wondered what is different with this picture, is it military starts to be intrested in MP ?

When i received a magazine with MP article in it, it was adressed to me as a professor :)

Last edited on Sat Mar 18th, 2006 14:03 by wrotek

Prof Trevor Marshall
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The US Public Health Service has a uniformed division, the Commissioned Corps. It has the promotional structure of the Navy, and many of the most dedicated staff members at NIH and FDA are lifetime members of the Commissioned Corps.
http://www.usphs.gov/

Lantern
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OK, I think I've found the reason why I can't seem to download the torrent file (from the ĀµTorrent FAQ);

ĀµTorrent's DHT implementation is the same as Mainline and BitComet's, but unfortunately this is incompatible with Azureus's implementation.

I think the file is relying on DHT as the tracker itself doesn't seem to be working for me. I think Azureus is less compatible overall with other bittorrent clients, so it might mean I'll have to get Azureus to get the FDA file. The other peer I can see might have to do the same also.

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HEY FOLKS, those of you with full copies of the DVD - please leave your Bittorrent on as SEEDS.Yes that's true. I leave mine on as a seed and Frans also does. There are a few client who seem to have problems with our tracker i guess. So when you want to be sure it works... use Azureus. And when it does not work with Azureus it's probably your firewall what is causing the problems.I downloaded Azureus and managed over 3 days to load the full ISO file at an impossibly slow bit rate, but despite poking about my router and firewall I couldn't get Azureus to work bidirectionally.  Maybe you have to have a public IP address, or at least exposure to the outside internet which I cannot get without paying extra.  I am behind at least one other router that doesn't belong to me.  So I am one of those scoflaws who downloaded the full DVD but cannot seed or supply it to anyone else.

A very short while ago I attempted to burn the ISO onto my wife's DVD burner only to discover that her Win2k and DVD burning sofware only supports data DVDs.  Arghh!  I guess I can burn it at work next week.

I tell young engineers that "High Technology" means that it barely works and sometimes doesn't but we have to ship it anyway.

john

Prof Trevor Marshall
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Hey John - you live just 20 minutes away - you could have driven over and picked up a DVD, case and all:)

Shadowzone:
Azureus is pretty CPU-intensive, but its security is unmatched (with the SafePeer plugin), and it is free, open source. So all the geeks use it:):) I can see an Aussie site trying to connect - but never seem to get through the handshake:X
Your client might also be confused by the fact that I use port 51001 (rather than the default 6881) so as to confuse my ISP as to the reason I am using so much outgoing bandwidth (9 gigabytes so far):)

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Heck, I could have walked over and back in the time it took to download. I have a fast connection, so my super slow download speeds were all about my mis-mastery of Azureus.

Have some of my bandwidth.  I have put another copy of the 50M version for downloading via right click here: http://tinyurl.com/n8bvf 

(Right click to save target.  Normal left click will not be as satisfying)

john 

 

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I finally was able to watch Trevor's latest presentation, and IMO it was fantastic. When did MP thinking give up the idea that Vitamin D was an inert precursor to 1,25D, and that it had immunosupressive actions on its own? Also, Trevor's computer human model has to have vast implications in the future development of designer medications. I can't believe the large drug companies aren't beating on your door to hire you :) Sam

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Sam,
The realization that all the Vitamin D metabolites were steroids came about when I started to model the molecules while preparing our recent paper.

Being a good scientist:) I was also drawn to model corticosteroids, the androgen hormones, and a number of other drugs which I thought might affect the immune system.

At this point I realized that the conversion of 7-dehydrocholesterol to 1,25-D is the primary pathway for activation of the VDR in man, and that ingested vitamin-D has no beneficial part to play in the immune system.

Vitamin D supplementation, which includes a sun-loving life style, is something which has come along quite recently (the last 50 years) and understanding the innate immune response at the molecular level made it clear that not only is Vitamin D not a vitamin, but it is actually immunosuppressive (generally harmful) in the doses currently being ingested by the population.

I did compute up the affinity of all the Vitamin D metabolites into the VDR, and also examined their mechanisms of action in the VDR. Only 1,25-D activates the VDR, both 25-D and Vitamin D inactivate it. Since these are present in such large quntities in the bloodstream these days (one thousand times the bloodstream concentration of 1,25-D) there was clearly the potential for interference in innate immunity. At about that time everything started to make sense...

I haven't published this through the peer-review journals, I doubt that the world is ready for this news quite yet.

..Trevor..

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Further to the previous message, I also found that 1,25-D had a ten times higher affinity for the Alpha1 and Beta1 Thyroid receptors than it did even for the VDR, and also a very high affinity for the Glucocorticoid receptor (approx same affinity as VDR). Clearly these are not the actions of a vitamin, but of a steroid, in this case, a powerful immune suppressant.

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Trevor, The androgen steroids acting on the immune system correlates with my experience also. In my early 20's I used testosterone and some of the anabolic steroids like Deca-Duarabolin and Winstrol for body-building, and had a dramatic reduction in TH1 symptoms, which were probably acting as Prednisone. My next question is, can you use your model to find out why an asthma medication called Clenbuterol can have the same effects as the androgens (dramatic lean muscle building and fat burning capabilities,fast recovery time, but W/O the androgenic effects in females such as hirsutism, reduction in TH1 symptoms) and then design a medication W/O the side effects of Clen (fast heart rate, intense muscle cramping).This could be the ultimate diet pill. We could go into business together and make millions LOL :) Sam

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At the end of presentation Dr Marshall is comparing vitamin D to prednisolone. I would like to know which metabolite of vitamin D is presented on the left side of the photo because it is not 1,25-D yes ?

Last edited on Mon Mar 20th, 2006 06:23 by wrotek

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I am comparing Vitamin-D3 to Prednisolone. The metabolism goes thus:-

7-dehydrocholesterol >> Vitamin-D3 >> 25hydroxyvitamin-D >> 1,25dihydroxyvitamin-D

At each 'hydroxy' stage an oxygen (and hydrogen) are added. You need the hydroxy at the 1-alpha position (designated as O1 in Figure 5 of our recent paper) in order to activate the VDR. Only 1,25-D has that. You also need the hydroxy group at the C25 position (in Figure 5 you can see that hydrogen-bonding to HIS305 and HIS397).
All the D-metabolites are seco-steroids, as I demonstrate on the video.

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Have viewed and orderd copies of this excellent presentation. Slide PDFs will be printed for benefit of those who will be given copies. (FDA isn't the only one that loves charts.) Excellent strategy, and nice touch to throw in corticosteroids and model relationships to D, as well as picking out a couple of other random advertised drugs and modelling those. Nice keyword choice with title.

Hopefully, there can now be no question to the authenticity or value of main topic models described for clinicians to use as they carefully consider errant consensus and researchers to focus new efforts.

Will look at some of the abstracts of other ARB papers in the "one a day" publication by multiple folks. Someone has got to be finding supporting evidence, and likely those and new researchers will not quickly discount the perspectives outlined in this report to the FDA.

And most of all, thank you.

Last edited on Tue Mar 21st, 2006 13:23 by jrfoutin

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Janet,

The one a day publication at pubmed is not about ARBs, but about VDR IMO. Just type in VDR in Pubmed and dr Marshall's paper will be at the third page. At least, it was a couple of days ago :cool:

Sincerely, Frans

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dr Marshall, did you ever read my suggestion Posted on: Sat Mar 18th, 2006 22:10 at page 2 of this thread? Is there anything we can do as a cohort?

Sincerely, Frans

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I'm afraid I'm a little confused about how to view the presentation and I wonder if I might not be the only one. I only have a slow 56 k modem, no dsl. I downloaded the first file that Trevor mentioned and it seemed to stall on my version of Real Video 9 (I think it was Real Video--it was certainly a Realnetworks product that was viewable). It seemed to be trying to stream the presentation but was interrupted and then the sound never came on.

OK, so then I tried to download Azureus and got very frustrated trying to make sense of it. Who ever designed the user interfaces for these products? For me it was totally confounding. I tried to find out ways to "enter in" magnet files, and then torrent files (or whatever they are). I even spoke to a software engineer with a Harvard Engineering degree. He confessed that he had no idea what a torrent file was and had never heard of Azureus.

Then it dawned on me that maybe I should use FTP to receive one of the files that Trevor mentions, but to tell you the truth, I just ran out of gas and interest in trying to work my way through all the techno computer speak which doesn't interest me in the least and I find trouble concentrating on in my current state.

Maybe someone who really loves all of this computer-dewiring-disentanglement can offer a few simple ideas. I don't need the "Idiots Guide" just a few pointers. Or maybe a 56k connection just won't cut it. Thanks.

Maybe I was on the right track thinking that FTP was the way to import and download one of the files...

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Jim,
The DVD of the presentation can be requested from
http://autoimmunityresearch.org/fdacder.htm

It comes in a presentation box and is suitable for loaning to friends and physicians:)

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jdc schreef:

OK, so then I tried to download Azureus and got very frustrated trying to make sense of it. Who ever designed the user interfaces for these products? For me it was totally confounding. I tried to find out ways to "enter in" magnet files, and then torrent files (or whatever they are). I even spoke to a software engineer with a Harvard Engineering degree. He confessed that he had no idea what a torrent file was and had never heard of Azureus.


Jim,

With al respect....It probably says more about the scope of the engineer then about Azureus and Torrent files. You can open torrentfiles just by clicking on them, how could it be simpler? A magnet file could be opened by "Open --> Torrent --> New URL".

But with a 56kbs connection it would surely cost you more on telephone bills then buying Dr. Marshall's DVD by mail.

Regards,

Jeroen

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dr Marshall,

I am looking at the presentation over and over and have more questions than answers  :D

Question: I can see prednisolone severely affects PPAR alpha and GCR (Glucose), is that perhaps a reason why people taking this drug usually gain weight?

Sincerely, Frans

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Frans,
The acronym "Glucocorticoid" is explained here
http://cancerweb.ncl.ac.uk/cgi-bin/omd?glucocorticoid

However, the function of the receptor called the GCR is not fully known, as mice who are bred without it do not survive gestation. Additionally, some Glucocorticoids are now known to have greater affinity for the MCR (MineralCorticoid Receptor) than they have for the GCR. Just as nomenclature got it all wrong with 'Vitamin' D, so the nuclear receptor names do not uniquely define their function.

As you surmise, any drug that affects PPAR-alpha, and, to a lesser extent, PPAR-gamma, can be expected to affect a patient's weight.

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Dr Marshall,

Something dawned on me when I was reading the pdf file again.

It states that PPAR alpha attenuates oxidative stress. Looking at all the numbers, one can see that PPAR alpha is hit heavily by D3 and 1,25D.

I know it is simplifying things, but I would say that the oxidative stress that is reported (?) in this diseases appears to be caused (or at least not stopped) because of the high levels of the D-metabolites.

This then implies that bringing the D-metabolites to normal levels, the body automatically starts attenuating oxidative stress also?

Sincerely, Frans

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Frans,
Look at the effects on NO (nitric oxide) metabolism, they are even more profound:)

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Trevor, You haven't published that yet  :)

I have been looking around on KEGG but can't find what you mean. Have tried pubmed also, but have to look further, I'll try VDR and nitric oxide.

Sincerely, Frans

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Trevor, I know this thread is 7 months old, but I still don't get it  :?

Can you give me a lead where to start looking?

Sincerely, Frans

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For an introduction to the topic, look at PMID 16020752
http://tinyurl.com/6y3nr

The PPAR gamma receptors are tightly involved in the body's response to NO, which is produced as the bacteria are killed. Elevated NO produces elevated Blood urea Nitrogen, inter alia...

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Thank you Trevor, this helps!



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