The Marshall Protocol Study Site Home

Search
   
Members

Calendar

Help

Home
Search by username
   Not logged in - Login | Register 
The Marshall Protocol Study Site > PROF. MARSHALL'S PERSPECTIVE > Prof. Marshall's Perspective > Chlorogenic Acid in Coffee is powerful Immune modulator


Chlorogenic Acid in Coffee is powerful Immune modulator
 Moderated by: Prof Trevor Marshall Page:  First Page Previous Page  ...  38  39  40  41  42  43   
 

New Topic

Reply

Print
AuthorPost
Dmitry
Support Team


Joined: Thu Apr 21st, 2016
Location: Saint-Petersburg, Russia
Posts: 1303
Status:  Offline
 Posted: Sat Nov 7th, 2020 23:43

Link

Quote

Reply
For one thing Chlorogenic Acid appears to be yet another antibiotic:

Synergistic Effect of Chlorogenic Acid and Caffeic Acid with Fosfomycin on Growth Inhibition of a Resistant Listeria monocytogenes Strain
https://pubs.acs.org/doi/10.1021/acsomega.0c00352

Chlorogenic acid and caffeic acid are phenolic acids, which are secondary metabolites of plants like blueberry(44−46) among others. Studies have shown that chlorogenic acid and caffeic acid have antimicrobial and antioxidant effects.(47,48) Chlorogenic acid gained substantial attention due to its various biological and pharmacological effects, e.g., anti-diabetics, anti-obesity, anti-oxidation, anti-inflammation, anti-hypertension, antimicrobial activities, and metabolism regulation. It was suggested that chlorogenic acid had bactericidal effects against some pathogens through various mechanisms.(49) It has been shown that the treatment of chlorogenic acid at the concentrations of 2MIC or 4MIC could induce cell constituents’ release, reduce intracellular ATP concentration, and reduce the intracellular pH.(45) Furthermore, chlorogenic acid could limit oxidation of polyunsaturated lipids and delayed the growth of L. monocytogenes.(44) Besides L. monocytogenes, chlorogenic acid also had growth inhibitory effects on other bacteria, such as Salmonella enteritidis and Staphylococcus aureus.(46,48) Similarly, caffeic acid was also shown to have inhibitory effects on L. monocytogenes, S. aureus, Escherichia coli, and Bacillus cereus.(45,50−52) The compound can increase membrane permeability, resulting in the release of cell contents and access of hydrophobic antibiotics.(45,53)

Last edited on Sat Nov 7th, 2020 23:45 by Dmitry



____________________
MP Sep16 25D17 125D21 | Sep17 25D22 125D27 | May18 25D10 125D29 | heavy brain fog, anxiety, fatigue, depression
SuperBiome
member


Joined: Tue Feb 2nd, 2016
Location: Birmingham, W Mids., United Kingdom
Posts: 76
Status:  Offline
 Posted: Sun Nov 8th, 2020 11:30

Link

Quote

Reply
So, what does THIS mean ? Are all/most of those with verified Th1 or Th17 conditions BETTER off avoiding coffee altogether ? ? ?

Please also see my post of 25 Oct 2020 - & implications for (100%) cocoa powder, . . . . & olive oil ?


All the best to all contributors & readers,
SB :)

PS: Dmitry, your picture looks ominous; would not want to come across you on a dark night in St Petersburg - & as things are, . . . . probably never shall ! ;)
----------------------------------------------------------------------------------------------------------------------------------

Last edited on Sun Nov 8th, 2020 15:43 by SuperBiome



____________________
MP started July 2016 | CFS/PVFS(1994) | low stamina, athlete's foot, sweat rash, sore throats, v poor sleep, hot flushes(flashes), poor response to training | "vitD temp. palliative effect" 2010~2012/3 | 25D=18.5ng/mL, Nov '15 & 7.4, Apr '17
Dmitry
Support Team


Joined: Thu Apr 21st, 2016
Location: Saint-Petersburg, Russia
Posts: 1303
Status:  Offline
 Posted: Sun Nov 8th, 2020 13:24

Link

Quote

Reply
SuperBiome wrote:
So, what does THIS mean ? Are all/most of those with verified Th1 or Th17 conditions BETTER off avoiding coffee altogether ? ? ?

Please also see my post of 25 Oct 2020 - & implications for (100%) cocoa powder, . . . . & olive oil ?


Well maybe it helps to intercept(in blood?) some of the bugs which later contribute to chronic microbiome otherwise..

Population do not seem to regress that much and too fast on caffeine comparing the quality of life on and off this substance (esp. compared to other "life enhancement" drugs) - coffee seems to cover up at least mild CFS for the majority of its consumers for decades without much of expected rapid regression - for ex my mom is a coffee drinker for like 40 years already and her CFS is at stable level for the last decades.

As for olive oil I've noticed that similar to coffee, it also contains polyphenols(phenolic-class antibiotics)...

http://www.thegreekoliveestate.com/healthy-evoo/
Research has found that Virgin Olive Oils have a Natural Polyphenol level that can range from anywhere between 50 – 5000 mg/kg (using NMR Spectroscopy). On Average, EVOOs (the highest quality Olive Oil) range between 100-250 mg/kg polyphenols.

Total Polyphenol Intake Is Inversely Associated with a Pro/Anti-Inflammatory Biomarker Ratio in European Adolescents of the HELENA Study
https://academic.oup.com/jn/article/150/6/1610/5813248

...

In any case people can not release their possession towards coffee and/or chocolate anyway so maybe we should start looking on some of its substances from a bright side. ;)



____________________
MP Sep16 25D17 125D21 | Sep17 25D22 125D27 | May18 25D10 125D29 | heavy brain fog, anxiety, fatigue, depression
SuperBiome
member


Joined: Tue Feb 2nd, 2016
Location: Birmingham, W Mids., United Kingdom
Posts: 76
Status:  Offline
 Posted: Sun Nov 8th, 2020 16:03

Link

Quote

Reply
Thanks Dmitry,

I'm interpreting that as not really much to worry about in the main ( - altho' there may be exceptions in individual cases) - for coffee ( - 100% cocoa powder ?) & even olive oil.

A few years ago, I came across early research which seem to show quite clearly that a 10-15ml daily dose of a high quality olive oil was beneficial to overall health, and at reducing the risk of neurological conditions like Alzheimer's and dementia. However, important questions might include 'for whom' ? Everyone ? Seems like a 'harmless' thing to trial, . . . given the length of time humans have been using it ?

Frankly, I'm having some 'fun' considering the gut microbiome, increasing FIBRE from natural foods, to support mine, and observing what the effects are. The gut microbiome determines which drugs we can metabolise, says Prof Martin Blaser, author of Missing Microbes.

Wishing all a PENSIVE Remembrance Day - may our tendencies to cause others, & this planet harm diminish faster & faster - THAT seems more important than ever now !

SB :)


----------------------------------------------------------------------------------------------------------------------------------



____________________
MP started July 2016 | CFS/PVFS(1994) | low stamina, athlete's foot, sweat rash, sore throats, v poor sleep, hot flushes(flashes), poor response to training | "vitD temp. palliative effect" 2010~2012/3 | 25D=18.5ng/mL, Nov '15 & 7.4, Apr '17
Dmitry
Support Team


Joined: Thu Apr 21st, 2016
Location: Saint-Petersburg, Russia
Posts: 1303
Status:  Offline
 Posted: Mon Nov 9th, 2020 17:33

Link

Quote

Reply

A few years ago, I came across early research which seem to show quite clearly that a 10-15ml daily dose of a high quality olive oil was beneficial to overall health, and at reducing the risk of neurological conditions like Alzheimer's and dementia. However, important questions might include 'for whom' ? Everyone ? Seems like a 'harmless' thing to trial, . . . given the length of time humans have been using it ?


So even 10..15ml of olive oil are being able to modulate immune response. Interesting...

I'm interpreting that as not really much to worry about in the main ( - altho' there may be exceptions in individual cases) - for coffee ( - 100% cocoa powder ?) & even olive oil.

Usually all anti inflammatory substances are highly addictive. :(

Last edited on Mon Nov 9th, 2020 17:52 by Dmitry



____________________
MP Sep16 25D17 125D21 | Sep17 25D22 125D27 | May18 25D10 125D29 | heavy brain fog, anxiety, fatigue, depression
Dmitry
Support Team


Joined: Thu Apr 21st, 2016
Location: Saint-Petersburg, Russia
Posts: 1303
Status:  Offline
 Posted: Mon Nov 16th, 2020 17:36

Link

Quote

Reply
Effects of decaffeination process on the phenolic content and antioxidant capacity of brewed coffees
https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.24.1_supplement.921.14
...This study suggests that some decaf methods may not alter phenolic content and antioxidant capacity...

Evaluating the effect of decaffeination on nutritional and antioxidant status of different coffee brands
https://www.researchgate.net/publication/330410913_Evaluating_the_effect_of_decaffeination_on_nutritional_and_antioxidant_status_of_different_coffee_brands

Total phenolic contents (TPC)

Phenolics and polyphenolic compounds constitute the main class of natural antioxidants present in plants and may contribute directly to antioxidative action (Awika et al., 2003) therefore it is necessary to calculate total phenolic content.

TPC was determined following a modified Follin–Ciocalteu method and results were expressed as gallic acid equivalents.

Total phenolic contents in Table 11 revealed:

* T3(caffeinated ground coffee) ---> 1720(mg/100g)
* T0(instant coffee) ----------------> 1711(mg/100g)
* T2(decaffeinated coffee beans) --> 1490(mg/100g)

Last edited on Mon Nov 16th, 2020 17:42 by Dmitry



____________________
MP Sep16 25D17 125D21 | Sep17 25D22 125D27 | May18 25D10 125D29 | heavy brain fog, anxiety, fatigue, depression
SuperBiome
member


Joined: Tue Feb 2nd, 2016
Location: Birmingham, W Mids., United Kingdom
Posts: 76
Status:  Offline
 Posted: Tue Nov 17th, 2020 19:28

Link

Quote

Reply
Am now wondering if there is any known connection/association between these 'polyphenols' ( - which, are molecules with multiple carbon or 'phenly/phenolic' rings ?) and short & medium chain fatty acids (SCFAs . . . & MCFAs) ? ? ?

One common MCFA is said to be butyric acid, which I surmise is a 'linear type' molecule, with four carbon atoms. These MCFAs are said to be important to health, and by-products of a healthy (gut) microbiome.

Any clarifications to these comments invited from those with greater insights into biochemistry, microbiome, nutrition and health !

SB :)
Somehow, . . . . hanging in there & coping, thru' continuing 'choppy waters' to life ! ! !



____________________
MP started July 2016 | CFS/PVFS(1994) | low stamina, athlete's foot, sweat rash, sore throats, v poor sleep, hot flushes(flashes), poor response to training | "vitD temp. palliative effect" 2010~2012/3 | 25D=18.5ng/mL, Nov '15 & 7.4, Apr '17
Dmitry
Support Team


Joined: Thu Apr 21st, 2016
Location: Saint-Petersburg, Russia
Posts: 1303
Status:  Offline
 Posted: Mon Mar 15th, 2021 17:44

Link

Quote

Reply
Coffee extracts suppress tryptophan breakdown in mitogen-stimulated peripheral blood mononuclear cells
https://pubmed.ncbi.nlm.nih.gov/25738401/

Results: Filtered extracts of coffee and decaffeinated coffee both suppressed tryptophan breakdown and neopterin formation in mitogen-stimulated PBMCs efficiently and in a dose-dependent manner. Of 4 coffee compounds tested individually, only gallic acid and less strong also caffeic acid had a consistent suppressive influence but also affected cell viability, whereas pure caffeine and chlorogenic acid exerted no relevant effect in the PBMC assay.

Regular consumption of black tea increases circulating kynurenine concentrations: A randomized controlled trial
https://pubmed.ncbi.nlm.nih.gov/26673554/

Results: Regular consumption of tea over 6 months, compared to control, did not significantly alter neopterin (p = 0.13) or tryptophan (p = 0.85) concentrations, but did result in significantly higher kynurenine (p = 0.016) and KYN/TRP (p = 0.012). Relative to the control group, in the tea group kynurenine and KYN/TRP increased during the treatment period by 0.28 μmol/L (95% CI: - 0.04, 0.60) and 3.2 μmol/mmol (95% CI: - 1.6, 8.0), respectively at 3 months, and by 0.48 μmol/L (95% CI: 0.16, 0.80) and 7.5 μmol/mmol (95% CI: 2.5, 12.5), respectively at 6 months.

Conclusions: Increased circulation of kynurenine and KYN/TRP following regular black tea consumption may indicate enhanced tryptophan breakdown, possibly due to immune activation-induced tryptophan degrading enzyme indoleamine 2,3-dioxygenase.

General significance: The influence of black tea consumption on biomarkers of immune system activation could relate to its general health benefits. Data suggests that the net effect strongly depends on the individual immune state, being stimulatory in healthy individuals, while acting more immune dampening in situations with an inflammatory background.

The kynurenine system and immunoregulation
https://pubmed.ncbi.nlm.nih.gov/21744051/

There is developing interest in the role of the kynurenines in the immune function. A considerable amount of evidence has accumulated as concerns interactions between the kynurenine pathway, cytokines and the nervous system. Indoleamine 2,3-dioxygenase (IDO) occupies a key position connecting the immune system and the kynurenine pathway. There are evidences of the immunosuppressive effect of IDO. Following the interferon (IFN)-mediated activation of antigen presenting cells, the induction of IDO and the kynurenine system exerts a counter-regulating effect, maintaining the homeostasis. Inhibition of T cell functions, activation of the regulatory T cells, and the inhibition of Natural Killer cells are among the important factors in the immunosuppressive effects of IDO and kynurenines. There is a close connection between cytokines (IFN-α, IFN-γ, TNF-α, TGF-β, IL-4 and IL-23) and the kynurenine system, and an imbalance in the TH1/TH2 cytokine profile may possibly lead to neurologic or psychiatric disorders.

As the tryptophan metabolic pathway is activated by pro-inflammatory stimuli, the anti-inflammatory effect of kynurenic acid provides a further feedback mechanism in modulating the immune responses.

Last edited on Mon Mar 15th, 2021 17:57 by Dmitry



____________________
MP Sep16 25D17 125D21 | Sep17 25D22 125D27 | May18 25D10 125D29 | heavy brain fog, anxiety, fatigue, depression

 Current time is 20:49
Page:  First Page Previous Page  ...  38  39  40  41  42  43   



* We can help you understand chronic disease, but only your physician is licensed to give you medical care *

Powered by WowBB 1.7 - Entire site Copyright © 2004-2021 Autoimmunity Research Foundation, All Rights Reserved
Click here to view our PRIVACY POLICY
Page processed in 0.0498 seconds (84% database + 16% PHP). 19 queries executed.