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 Moderated by: Prof Trevor Marshall Page:  First Page Previous Page  1  2   
 

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jcwat101
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 Posted: Wed Aug 29th, 2007 13:41

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I am pretty sure the answer would be:

ATTENTION: Unnecessary dietary supplementation and OTC medications are to be avoided because we cannot know how they might interact with the medications on the Marshall Protocol, or how they might affect the immune system.

Also, using SAMe and related substances would be in the category of combining the MP with another protocol and there could be unknown effects on the efficacy of the MP.

See the links Meg and Barb posted, above, for the MP's views on dealing with depression, anxiety and mental illness.

Joyce Waterhouse



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20 yrs with CFS/FM/Lyme/IBS, food sensitivities; 1,25D/25D 8/04:64/11 http://SynergyHN.wordpress.com
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 Posted: Wed Aug 29th, 2007 23:26

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Joyce is correct about unnecessary supplementation. But we take intolerable depression very seriously. We don't want members to endure a depression that could be dangerous. If your depression is intolerable to you, please take whatever medication that works to help you feel better (including SAM-e) providing your doctor approves. 

Frans
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 Posted: Fri Dec 28th, 2007 13:29

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Hi all,

I have been looking a little into serotonin and histamine. It seems a lot of anti-depressants and anti pschychotics work on these two.

What I found about serotonin was rather interesting.

It seems serotonin plays a role in oxidative stress. If serotonin binds to the 5-HTR 2 receptor it downregulates something called myeloperoxidase, thereby downregulating oxidative stress.

Now, the most interesting thing is that this receptor, which essentially is the serotonin 2 receptor (5-HTR is the chemical name), is expressed by the VDR... See the tables of Wang et al.

No, I am just a layman, so I hope someone with more knowledge can check the paper out to see if I am right.

This piece of information might be another reason why beni works wonder against pain. Simple explanation:  if VDR doens't work, the serotonin 2 receptor isn't expressed, leading to oxidative stress going haywire.

PMID: 18041649

Sincerely, Frans

PS  in the tables of wang et al one finds that a lot of serotonin receptors are expressed by the VDR (link to depression?), as are the histamine H1, 2 and 4 receptors (link to psychosis allergy?)



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Bella
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 Posted: Fri Dec 28th, 2007 22:04

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Frans,

Funny thing that you should be reading up on this subject. I find it very interesting since everything with me started with the diagnosis of depression then many years later Fibromyalgia, Chronic Fatigue and Lyme disease (which we know now is all the same..different color cats but all are cats) The Marshall Protocol has put me in a place that is indescribable when it comes to my depression. I  had depression  (pre MP) to the point of wanting to commit suicide many times not to mention life was a struggle everyday.

Mood swings were something that was a part of daily life for me. My TH1 symptoms started as depression then came the pain, fatigue, and poor sleep, daytime sleepiness etc etc...Antidepressants saved me but never have they relieved/gotten rid of symptoms....like the MP. I am now starting to live a life I have never known. I am not the first member to note this but I am amazed at just how good things are.....Of course when I herx the depression, moods and sleep can worsen temporarily...but when I am not herxing WOW WOW WOW. I just cant say enough about it. I keep getting amazed when I see the progress I am making. It is like a dream come true....a life I have never known.

Jeannine



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Frans
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 Posted: Sat Dec 29th, 2007 13:51

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Jeannine,

Well, the plot thickens.

As I mentoined, several histamine receptors are also probably transcribed by the VDR, namely H1, 2 and 4. See Wang et al.

One thing that stands out once one looks into the histamine receptors is their role in sleeping.

The histamine H1 receptor is mentioned as being the most important receptor in the so-called circadian rhythm. This is a fancy word for what we know as bio-rythm, sleeping at night and waking at day.

So, if the VDR doesn't work, it seems only logical that our sleeppatterns get disturbed, since the main receptor regulating our biorhythm isn't there.

Sincerely, Frans



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Burn-out/nervous breakdown Jan01 125D 48 25D8.48 Ph1Nov06 ModPh2Jan07 Ph2Apr08 Cipramil Seroquel NoIRs lite exp r/t work cover up 25D3.9(Oct07)
Prof Trevor Marshall
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 Posted: Sat Dec 29th, 2007 15:38

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As the section on clinical studies in my new paper concludes:
"Surely we are being naive if we expect the exogenous modulation of a metabolism that is responsible for the expression of over a thousand genes to provide a simple go/no-go result?"
..Trevor..

Frans
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 Posted: Wed May 7th, 2008 10:05

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Hi all, I just found a paper confirming the Histamine H1 receptor as being transcribed by the VDR, see PMID 17547532.

This receptor is reported to be the most inportant in maintaining a normal circadian rythm, our biological clock.

So, sleepproblems are not really unexpected in these th1 diseases...

Sincerely, Frans



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Burn-out/nervous breakdown Jan01 125D 48 25D8.48 Ph1Nov06 ModPh2Jan07 Ph2Apr08 Cipramil Seroquel NoIRs lite exp r/t work cover up 25D3.9(Oct07)
Joyful
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 Posted: Wed May 7th, 2008 12:09

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Frans,

I truly appreciate your active investigation into these issues as I have been unable to sleep deeply without taking a small amount of an anti-histamine at bedtime.

Knowing that being on the MP is resolving the underlying cause of my sleep problems reassures me that I am on the right track.

Thanks!
~Joyful~



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